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Found 36 with Last Name = 'leung' and Initial = 'ak'
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8798(CHEMBL47787 | Pyrazolo[3,4-d]pyrimidine 6 | benzyl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of p56 Lck tyrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Lactobacillus casei DHFRMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8798(CHEMBL47787 | Pyrazolo[3,4-d]pyrimidine 6 | benzyl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of Src protein tryrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50145570(1H-Indole-2-carboxylic acid (4-{4-amino-1-[4-(4-me...)
Affinity DataIC50:  20nMAssay Description:Inhibition of p56 Lck tyrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8807(CHEMBL43773 | N-(4-{4-amino-1-[4-(4-methylpiperazi...)
Affinity DataIC50:  24nMAssay Description:Inhibition of p56 Lck tyrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8803(CHEMBL295601 | N-(4-{4-amino-1-[4-(4-methylpiperaz...)
Affinity DataIC50:  28nMAssay Description:Inhibition of p56 Lck tyrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50145571(1-Methyl-1H-indole-2-carboxylic acid (4-{4-amino-1...)
Affinity DataIC50:  37nMAssay Description:Inhibition of p56 Lck tyrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50145570(1H-Indole-2-carboxylic acid (4-{4-amino-1-[4-(4-me...)
Affinity DataIC50:  56nMAssay Description:Inhibition of Src protein tryrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8807(CHEMBL43773 | N-(4-{4-amino-1-[4-(4-methylpiperazi...)
Affinity DataIC50:  57nMAssay Description:Inhibition of Src protein tryrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50145572(3-{4-[(Furan-2-ylmethyl)-amino]-3-methoxy-phenyl}-...)
Affinity DataIC50:  64nMAssay Description:Inhibition of p56 Lck tyrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50145571(1-Methyl-1H-indole-2-carboxylic acid (4-{4-amino-1...)
Affinity DataIC50:  70nMAssay Description:Inhibition of Src protein tryrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8797(CHEMBL297363 | N-(4-{4-amino-1-[4-(4-methylpiperaz...)
Affinity DataIC50:  93nMAssay Description:Inhibition of p56 Lck tyrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50145572(3-{4-[(Furan-2-ylmethyl)-amino]-3-methoxy-phenyl}-...)
Affinity DataIC50:  97nMAssay Description:Inhibition of Src protein tryrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8803(CHEMBL295601 | N-(4-{4-amino-1-[4-(4-methylpiperaz...)
Affinity DataIC50:  155nMAssay Description:Inhibition of Src protein tryrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8797(CHEMBL297363 | N-(4-{4-amino-1-[4-(4-methylpiperaz...)
Affinity DataIC50:  189nMAssay Description:Inhibition of Src protein tryrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  190nMAssay Description:Inhibition of Mycobacterium avium DHFRMore data for this Ligand-Target Pair
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50145570(1H-Indole-2-carboxylic acid (4-{4-amino-1-[4-(4-me...)
Affinity DataIC50:  520nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2 with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8798(CHEMBL47787 | Pyrazolo[3,4-d]pyrimidine 6 | benzyl...)
Affinity DataIC50:  521nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2 with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  620nMAssay Description:Inhibition of Lactobacillus casei DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50145572(3-{4-[(Furan-2-ylmethyl)-amino]-3-methoxy-phenyl}-...)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2 with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8807(CHEMBL43773 | N-(4-{4-amino-1-[4-(4-methylpiperazi...)
Affinity DataIC50:  1.13E+3nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2 with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50145571(1-Methyl-1H-indole-2-carboxylic acid (4-{4-amino-1...)
Affinity DataIC50:  1.48E+3nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2 with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8803(CHEMBL295601 | N-(4-{4-amino-1-[4-(4-methylpiperaz...)
Affinity DataIC50:  2.45E+3nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2 with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  2.73E+3nMAssay Description:Inhibition of Toxoplasma gondii DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8797(CHEMBL297363 | N-(4-{4-amino-1-[4-(4-methylpiperaz...)
Affinity DataIC50:  4.68E+3nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2 with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of Pneumocystis carinii DHFRMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8798(CHEMBL47787 | Pyrazolo[3,4-d]pyrimidine 6 | benzyl...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2 activity with 1mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8803(CHEMBL295601 | N-(4-{4-amino-1-[4-(4-methylpiperaz...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2 activity with 1mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50145571(1-Methyl-1H-indole-2-carboxylic acid (4-{4-amino-1...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2 activity with 1mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8797(CHEMBL297363 | N-(4-{4-amino-1-[4-(4-methylpiperaz...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2 activity with 1mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8807(CHEMBL43773 | N-(4-{4-amino-1-[4-(4-methylpiperazi...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2 activity with 1mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  1.33E+5nMAssay Description:Inhibition of rat liver DHFRMore data for this Ligand-Target Pair
TargetADP-ribose glycohydrolase MACROD2(Homo sapiens)
Mcdaniel College

Curated by ChEMBL
LigandPNGBDBM50595206(CHEMBL5205107)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of N-terminal His-TEV-V5 tagged human Mdo2 (7 to 243 residues) expressed in Escherichia coli BL21 (DE3) using BIO-6His tagged linker pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetADP-ribose glycohydrolase MACROD2(Homo sapiens)
Mcdaniel College

Curated by ChEMBL
LigandPNGBDBM50595207(CHEMBL5208626)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of N-terminal His-TEV-V5 tagged human Mdo2 (7 to 243 residues) expressed in Escherichia coli BL21 (DE3) using BIO-6His tagged linker pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetADP-ribose glycohydrolase MACROD2(Homo sapiens)
Mcdaniel College

Curated by ChEMBL
LigandPNGBDBM50088433(Dihydralazine)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibition of human Mdo2More data for this Ligand-Target Pair
In DepthDetails PubMed