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Found 831 with Last Name = 'long' and Initial = 'yq'
TargetTrypsin(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50421510(CHEMBL239127)
Affinity DataKi:  0.100nMAssay Description:Compound was tested for inhibition of Sunflower beta-trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50421510(CHEMBL239127)
Affinity DataKi:  0.920nMAssay Description:Compound was tested for inhibition of Matriptase from human breast cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin-3(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50421510(CHEMBL239127)
Affinity DataKi:  1.10nMAssay Description:Compound was tested for inhibition of bovine beta trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50274428(CHEMBL4127538)
Affinity DataKi:  2nMAssay Description:Binding affinity to human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50116661(CHEMBL75668 | N-[(S)-1-(2,5-Dihydro-pyrrol-1-ylmet...)
Affinity DataKi:  3.10nMAssay Description:Displacement of bound [3H]-diprenorphine in cloned rat Opioid receptor kappa 1 expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50116659(2-(3,4-Dichloro-phenyl)-N-[(S)-1-(2,5-dihydro-pyrr...)
Affinity DataKi:  5.70nMAssay Description:Displacement of bound [3H]-diprenorphine in cloned rat Opioid receptor kappa 1 expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50274429(CHEMBL4126162)
Affinity DataKi:  15nMAssay Description:Binding affinity to human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50274430(CHEMBL4127496)
Affinity DataKi:  24nMAssay Description:Binding affinity to human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50045060(CHEMBL3309789)
Affinity DataKi:  1.33E+3nMAssay Description:Competitive inhibition of PTP1B (unknown origin) using pNPP as substrate by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibitory activity against Bcl-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50421510(CHEMBL239127)
Affinity DataKi:  5.05E+3nMAssay Description:Compound was tested for inhibition of bovine ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase plasminogen activator surface receptor(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50421510(CHEMBL239127)
Affinity DataKi:  5.00E+5nMAssay Description:Compound was tested for microPa) Urokinase-type plasminogen activator from human urineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50327846(1-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-3-(4-(t...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of soluble epoxide hydrolase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496759(CHEMBL3222130)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496748(CHEMBL3222118)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496754(CHEMBL3222131)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496753(CHEMBL3222129)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50335557(CHEMBL1652605 | N,N-dipropyl-N'-[4-({[(1H-imidazol...)
Affinity DataIC50:  0.610nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 (unknown origin) expressed in CHO cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496760(CHEMBL3222119)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50458294(CHEMBL4210165)
Affinity DataIC50: <4nMAssay Description:Antagonist activity at CXCR4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50458281(CHEMBL4217502)
Affinity DataIC50: <4nMAssay Description:Antagonist activity at CXCR4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496757(CHEMBL3222121)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50074167(CHEMBL348815 | Phenethyl-{(S)-1-[2-(5-[1,2,4]triaz...)
Affinity DataIC50: >7nMAssay Description:Inhibition of SDF-1 binding to CXCR4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50074178((1-Methyl-1-phenyl-ethyl)-{(S)-1-[2-(5-[1,2,4]tria...)
Affinity DataIC50: >7nMAssay Description:Inhibition of SDF-1 binding to CXCR4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50458290(CHEMBL4215051)
Affinity DataIC50: >7nMAssay Description:Inhibition of SDF-1 binding to CXCR4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50458283(CHEMBL4212661)
Affinity DataIC50: >7nMAssay Description:Inhibition of SDF-1 binding to CXCR4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496746(CHEMBL3222115)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496747(CHEMBL3222117)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50200480(CHEMBL3965352)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of Smo-mediated Hh signalling pathway in mouse Shh Light2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50458288(CHEMBL4218006)
Affinity DataIC50:  11nMAssay Description:Inhibition of SDF-1 binding to CXCR4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at CCR2 (unknown origin) expressed in CHOK1 cells co-expressing Ga16 assessed as inhibition of CCL2 induced intracellular Ca2+ mo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50458286(CHEMBL2367715)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human MT4 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50314723(CHEMBL1090041 | endo-(S)-N-(4-fluorobenzyl)-4-(3-(...)
Affinity DataIC50:  14.4nMAssay Description:Antagonist activity at CCR5 receptor expressed in CHO cells assessed as inhibition of RANTES-induced [32S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50458287(CHEMBL4213081)
Affinity DataIC50:  15nMAssay Description:Inhibition of SDF-1 binding to CXCR4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496758(CHEMBL3222124)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50458297(CHEMBL4213087)
Affinity DataIC50: <20nMAssay Description:Antagonist activity at CXCR4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50458292(CHEMBL4218011)
Affinity DataIC50: <20nMAssay Description:Antagonist activity at CXCR4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50458293(CHEMBL4205801)
Affinity DataIC50: <20nMAssay Description:Antagonist activity at CXCR4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50080122(CHEMBL407859 | Cyclo peptide analogue)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity of the compound against Growth factor receptor bound protein 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50458279(CHEMBL4206706)
Affinity DataIC50:  27nMAssay Description:Inhibition of SDF-1 binding to CXCR4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50155310(CHEMBL3779982)
Affinity DataIC50:  36nMAssay Description:Displacement of [125I]SDF-1 from human CXCR4 expressed in HEK293 cell membranes after 1.5 hrs by Topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50:  39nMAssay Description:Inhibition of Smo-mediated Hh signalling pathway in mouse Shh Light2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496756(CHEMBL3222116)
Affinity DataIC50:  42nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496751(CHEMBL3222123)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496745(CHEMBL3222114)
Affinity DataIC50:  46nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50200484(CHEMBL3960082)
Affinity DataIC50:  46nMAssay Description:Inhibition of Smo-mediated Hh signalling pathway in mouse Shh Light2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50147397(CHEMBL444897 | Hexapeptide derivative)
Affinity DataIC50:  50nMAssay Description:Competitive binding affinity against Growth factor receptor bound protein 2 was assessed using SHC(pTyr-317) phospopeptide in biacore surface plasmon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50200482(CHEMBL3978393)
Affinity DataIC50:  53nMAssay Description:Inhibition of Smo-mediated Hh signalling pathway in mouse Shh Light2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50183425(CHEMBL203761 | cyclo-(CH2-CO-Gla-Leu-(3'-NH2-Tyr)-...)
Affinity DataIC50:  58nMAssay Description:Inhibition of recombinant GRB2-SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50274427(CHEMBL4128498)
Affinity DataIC50:  61nMAssay Description:Antagonist activity at CCR2 (unknown origin) expressed in CHOK1 cells co-expressing Ga16 assessed as inhibition of CCL2 induced intracellular Ca2+ mo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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