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Found 90 with Last Name = 'machutta' and Initial = 'ca'
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93049(TLM analog, 6)
Affinity DataKi:  460nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93048(TLM analog, 5)
Affinity DataKi:  900nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM50241313((5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1...)
Affinity DataKi:  1.90E+3nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93046(TLM analog, 3)
Affinity DataKi:  7.10E+3nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93054(TLM analog, 11)
Affinity DataKi:  8.00E+3nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93048(TLM analog, 5)
Affinity DataKi:  8.20E+3nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93049(TLM analog, 6)
Affinity DataKi:  1.21E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93059(TLM analog, 16)
Affinity DataKi:  1.38E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93047(TLM analog, 4)
Affinity DataKi:  1.60E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93051(TLM analog, 8)
Affinity DataKi:  2.19E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93060(TLM analog, 17)
Affinity DataKi:  3.20E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93045(TLM analog, 2)
Affinity DataKi:  4.69E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93050(TLM analog, 7)
Affinity DataKi:  6.52E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93057(TLM analog, 14)
Affinity DataKi:  6.90E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93058(TLM analog, 15)
Affinity DataKi:  7.74E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93056(TLM analog, 13)
Affinity DataKi:  9.28E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93053(TLM analog, 10)
Affinity DataKi:  1.02E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93052(TLM analog, 9)
Affinity DataKi:  1.05E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM50241313((5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1...)
Affinity DataKi:  1.75E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93047(TLM analog, 4)
Affinity DataKi:  3.05E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93046(TLM analog, 3)
Affinity DataKi:  3.57E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery

LigandPNGBDBM93055(TLM analog, 12)
Affinity DataKi: >4.00E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50:  79nMAssay Description:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400778(CHEMBL2204995)
Affinity DataIC50:  174nMAssay Description:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400779(CHEMBL2204998)
Affinity DataIC50:  324nMAssay Description:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400780(CHEMBL2204996)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400782(CHEMBL2204999)
Affinity DataIC50:  2.51E+3nMAssay Description:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400778(CHEMBL2204995)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400779(CHEMBL2204998)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400783(CHEMBL1608462)
Affinity DataIC50:  1.06E+4nMAssay Description:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETD7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibition of SET7 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of PRMT3 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETD7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400778(CHEMBL2204995)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of SET7 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400778(CHEMBL2204995)
Affinity DataIC50:  7.40E+4nMAssay Description:Inhibition of PRMT3 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400778(CHEMBL2204995)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of DNMT1 using polydi-dc as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400779(CHEMBL2204998)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PRMT5 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PRMT5 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400778(CHEMBL2204995)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PRMT5 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETMAR(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400779(CHEMBL2204998)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SETMAR using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETMAR(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SETMAR using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETMAR(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400778(CHEMBL2204995)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SETMAR using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400779(CHEMBL2204998)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SUV39H1 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SUV39H1 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400778(CHEMBL2204995)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SUV39H1 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SUV39H2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400779(CHEMBL2204998)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SUV39H2 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SUV39H2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SUV39H2 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase 2A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400778(CHEMBL2204995)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MLL1 using core histone as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400779(CHEMBL2204998)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PRMT4 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400779(CHEMBL2204998)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PRMT3 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400778(CHEMBL2204995)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PRMT1 using histone H4 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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