Compile Data Set for Download or QSAR
maximum 50k data
Found 157 with Last Name = 'mann' and Initial = 'cw'
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50505323(CHEMBL4556848)
Affinity DataKi:  2nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50505321(CHEMBL2402091)
Affinity DataKi:  8nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50505321(CHEMBL2402091)
Affinity DataKi:  33nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50229129(4-Methyl-piperazine-1-carboxylic acid [(S)-1-((E)-...)
Affinity DataKi:  80nMAssay Description:Irreversible inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50229129(4-Methyl-piperazine-1-carboxylic acid [(S)-1-((E)-...)
Affinity DataKi:  220nMAssay Description:Irreversible inhibition of Trypanosoma cruzi cruzipainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50229129(4-Methyl-piperazine-1-carboxylic acid [(S)-1-((E)-...)
Affinity DataKi:  270nMAssay Description:Irreversible inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256882(6-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataKi:  330nMAssay Description:Inhibition of human neurokinin NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50229129(4-Methyl-piperazine-1-carboxylic acid [(S)-1-((E)-...)
Affinity DataKi:  390nMAssay Description:Irreversible inhibition of human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50505323(CHEMBL4556848)
Affinity DataKi:  690nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256882(6-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataKi:  850nMAssay Description:Inhibition of human histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50331768((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50:  0.400nMAssay Description:Reversible inhibition of Trypanosoma cruzi cruzipainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50505322(CHEMBL4557939)
Affinity DataIC50:  0.800nMAssay Description:Reversible inhibition of Trypanosoma cruzi cruzipainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50331787((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50:  1nMAssay Description:Reversible inhibition of Trypanosoma cruzi cruzipainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50244213(5-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256836(7-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [D-Trp6]-GnRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315277(5-((4-(2-(4-tert-butylphenyl)imidazo[1,2-a]pyridin...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256834(7-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  3.5nMAssay Description:Displacement of [D-Trp6]-GnRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50244213(5-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at human recombinant GnRH receptor expressed in HEK293 cells assessed as reduction in (D-Trp6)-GnRH-stimulated IP production by w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315276(5-((4-(2-(4-tert-butylphenyl)imidazo[1,2-a]pyridin...)
Affinity DataIC50:  4.30nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50244211(6-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  4.90nMAssay Description:Displacement of [D-Trp6]-GnRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315277(5-((4-(2-(4-tert-butylphenyl)imidazo[1,2-a]pyridin...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at human recombinant GNRH receptor assessed as inhibition of D-Trp6-GNRH-induced IP accumulation after 1 hr by rapid filtration a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256835(7-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  5.60nMAssay Description:Displacement of [D-Trp6]-GnRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315277(5-((4-(2-(4-tert-butylphenyl)imidazo[1,2-a]pyridin...)
Affinity DataIC50:  5.70nMAssay Description:Displacement of [125I]D-Trp6-GnRH from rat recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258205(2-(4-tert-butylphenyl)-4-(4-((1-ethyl-5-methyl-1H-...)
Affinity DataIC50:  5.80nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315275(2-(4-tert-butylphenyl)-8-(4-((1-ethyl-5-methyl-1H-...)
Affinity DataIC50:  6.70nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258205(2-(4-tert-butylphenyl)-4-(4-((1-ethyl-5-methyl-1H-...)
Affinity DataIC50:  7nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256834(7-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  7.40nMAssay Description:Antagonist activity at human GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated [3H]IP reductionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258018(2-(4-tert-butylphenyl)-4-(4-((2-methyl-1H-imidazol...)
Affinity DataIC50:  7.5nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50257669(2-(4-tert-butylphenyl)-4-(4-((1,2-diethyl-5-methyl...)
Affinity DataIC50:  8nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50331787((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50:  9nMAssay Description:Reversible inhibition of human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50244211(6-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  9.40nMAssay Description:Antagonist activity at human GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated [3H]IP reductionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256836(7-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  9.70nMAssay Description:Antagonist activity at human GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated [3H]IP reductionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315271(2-(4-tert-butylphenyl)-8-(4-((2-ethyl-5-methyl-1H-...)
Affinity DataIC50:  9.80nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50261251(2-(4-tert-butylphenyl)-4-(4-((2-ethyl-4-methyl-1H-...)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50257513(2-(4-tert-butylphenyl)-4-(4-((1,2-dimethyl-1H-imid...)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50257516(2-(4-tert-butylphenyl)-4-(4-((1-ethyl-2-methyl-1H-...)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50257668(2-(4-tert-butylphenyl)-4-(4-((1,2-diethyl-1H-imida...)
Affinity DataIC50:  11nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258245(2-(4-tert-butylphenyl)-4-(4-((5-methyl-1-propyl-1H...)
Affinity DataIC50:  12nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256882(6-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  12nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256882(6-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  12nMAssay Description:Displacement of [D-Trp6]-GnRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315275(2-(4-tert-butylphenyl)-8-(4-((1-ethyl-5-methyl-1H-...)
Affinity DataIC50:  12nMAssay Description:Displacement of [125I]D-Trp6-GnRH from rat recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50257669(2-(4-tert-butylphenyl)-4-(4-((1,2-diethyl-5-methyl...)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human recombinant GnRH receptor expressed in HEK293 cells assessed as reduction in (D-Trp6)-GnRH-stimulated IP production by w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256835(7-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated [3H]IP reductionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258205(2-(4-tert-butylphenyl)-4-(4-((1-ethyl-5-methyl-1H-...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human recombinant GnRH receptor expressed in HEK293 cells assessed as reduction in (D-Trp6)-GnRH-stimulated IP production by w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258205(2-(4-tert-butylphenyl)-4-(4-((1-ethyl-5-methyl-1H-...)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human recombinant GNRH receptor assessed as inhibition of D-Trp6-GNRH-induced IP accumulation after 1 hr by rapid filtration a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256881(6-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  16nMAssay Description:Displacement of [D-Trp6]-GnRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256881(6-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated [3H]IP reductionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256834(7-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  17nMAssay Description:Displacement of [D-Trp6]-GnRH from rat recombinant GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50257561(2-(4-tert-butylphenyl)-4-(4-((2-methyl-1-propyl-1H...)
Affinity DataIC50:  18nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50244213(5-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  18nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from rat GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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