Affinity DataIC50: 1nMAssay Description:Inhibition of partially purified HDAC isolated from human M8 cells enzyme fraction pre-incubated for 5 mins before [3H]acetylated histone addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of rat brain PKC using RGFR derived peptide substrateMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 3(Homo sapiens (Human))
Pak Research Center
Curated by ChEMBL
Pak Research Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-tagged PAK3 (unknown origin) expressed in Escherichia coli using peptide PC9 substrateMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Pak Research Center
Curated by ChEMBL
Pak Research Center
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of PAK1 in estrogen-stimulated human MCF7 cells incubated for 48 hrs by immunoblot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of PAK1 in v-Ha-RAS-transformed mouse NIH/3T3 cells incubated for 48 hrs by immunoblot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of ETK phosphorylation in mouse RAS-3T3 cells incubated for 1 hr by immunoblotMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human COX2 using arachidonic acid as substrate measured after 2 to 5 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of FYN (unknown origin) by cell culture based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of FYN (unknown origin) by cell culture based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Pak Research Center
Curated by ChEMBL
Pak Research Center
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of flag-tagged MLK3 (unknown origin) expressed in human HeLa cells assessed as reduction in enzyme autophosphorylation incubated for 20 mi...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Pak Research Center
Curated by ChEMBL
Pak Research Center
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of PAK1 in human A549 cells using myelin basic protein as substrate preincubated for 24 hrs followed by PAK1 immunoprecipation and substra...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant human COX2 using arachidonic acid as substrate measured after 2 to 5 minsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Pak Research Center
Curated by ChEMBL
Pak Research Center
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of PAK1 in human A549 cellsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Pak Research Center
Curated by ChEMBL
Pak Research Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PAK1 by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Pak Research Center
Curated by ChEMBL
Pak Research Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PAK1 in v-Ha-RAS-transformed mouse NIH/3T3 cells incubated for 1 hr by immunoblot analysisMore data for this Ligand-Target Pair
TargetCell division control protein 42 homolog/Ras-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Kagoshima University
Curated by ChEMBL
Kagoshima University
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of RAC1/CDC42 in human ovarian cancer cellsMore data for this Ligand-Target Pair
TargetCell division control protein 42 homolog/Ras-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Kagoshima University
Curated by ChEMBL
Kagoshima University
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of RAC1/CDC42 in human ovarian cancer cellsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Pak Research Center
Curated by ChEMBL
Pak Research Center
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of HA-PAK1 (unknown origin) using histone H4 substrate and [gamma-32P] ATP by autoradiographyMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Pak Research Center
Curated by ChEMBL
Pak Research Center
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of PAK1 in human MCF7 cells transfected with constitutively active NH2-terminally truncated C1199 Tiam1 constructMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus assessed as reduction in PGE2 synthesis using [3H]arachidonic acid substrate by HPLC an...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Pak Research Center
Curated by ChEMBL
Pak Research Center
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant human PAK1 by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Pak Research Center
Curated by ChEMBL
Pak Research Center
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of recombinant human PAK1 by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Pak Research Center
Curated by ChEMBL
Pak Research Center
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PAK1 (unknown origin) by cell culture based assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Pak Research Center
Curated by ChEMBL
Pak Research Center
Curated by ChEMBL
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of PAK1 in human A549 cells using myelin basic protein as substrate preincubated for 24 hrs followed by PAK1 immunoprecipation and substra...More data for this Ligand-Target Pair