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Found 778 with Last Name = 'mclay' and Initial = 'im'
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339718((S)-2-(5-chlorothiophen-2-yl)-N-(2-oxo-1-(1,2,3,4-...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339708((S)-2-(5-chlorothiophen-2-yl)-N-(1-(5-fluoro-1,2,3...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339713((S)-6-chloro-N-(2-oxo-1-(2,3,4,5-tetrahydro-1H-ben...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339716((S)-6-chloro-N-(1-(6-fluoro-2,3,4,5-tetrahydro-1H-...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339714((S)-3-chloro-N-(2-oxo-1-(2,3,4,5-tetrahydro-1H-ben...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339711((S)-3-chloro-N-(1-(7-fluoro-1,2,3,4-tetrahydroisoq...)
Affinity DataKi:  1nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339712((S,E)-2-(5-chlorothiophen-2-yl)-N-(2-oxo-1-(2,3,4,...)
Affinity DataKi:  1nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339719((S)-6-chloro-N-(2-oxo-1-(1,2,3,4-tetrahydroisoquin...)
Affinity DataKi:  1nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339717((S)-2-(5-chlorothiophen-2-yl)-N-(1-(2-methyl-1,2,3...)
Affinity DataKi:  1nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339720((S)-3-chloro-N-(2-oxo-1-(1,2,3,4-tetrahydroisoquin...)
Affinity DataKi:  1nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339706((S)-6-chloro-N-(1-(5-fluoro-1,2,3,4-tetrahydroisoq...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339715((S)-2-(5-chlorothiophen-2-yl)-N-(1-(6-fluoro-2,3,4...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339710((S)-3-chloro-N-(1-(5-fluoro-1,2,3,4-tetrahydroisoq...)
Affinity DataKi:  2nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339709((S)-2-(5-chlorothiophen-2-yl)-N-(1-(7-fluoro-1,2,3...)
Affinity DataKi:  2nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306134(6-chloro-N-((S)-1-(2-fluoro-4-((S)-1-(methylamino)...)
Affinity DataKi:  2nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339707((S)-6-chloro-N-(1-(7-fluoro-1,2,3,4-tetrahydroisoq...)
Affinity DataKi:  3nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339721((S)-2-(5-chlorothiophen-2-yl)-N-(2-oxo-1-(1,2,3,4-...)
Affinity DataKi:  8nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339722((S)-6-chloro-N-(2-oxo-1-(1,2,3,4-tetrahydroisoquin...)
Affinity DataKi:  10nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339723((S)-3-chloro-N-(2-oxo-1-(1,2,3,4-tetrahydroisoquin...)
Affinity DataKi:  15nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50354851(FLUTICASONE FUROATE | Veramyst)
Affinity DataIC50:  0.0398nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414604(CHEMBL551816)
Affinity DataIC50:  0.0790nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417875(CHEMBL1668063)
Affinity DataIC50:  0.0794nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417887(CHEMBL1668077)
Affinity DataIC50:  0.126nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414609(CHEMBL550730)
Affinity DataIC50:  0.126nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473625(CHEMBL69319)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of p38-related TNF alpha release by human monocyte cell line (THP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414610(CHEMBL564160)
Affinity DataIC50:  0.200nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417890(CHEMBL1668080)
Affinity DataIC50:  0.200nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417889(CHEMBL1668079)
Affinity DataIC50:  0.251nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414611(CHEMBL560797)
Affinity DataIC50:  0.251nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414607(CHEMBL563812)
Affinity DataIC50:  0.251nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414605(CHEMBL556231)
Affinity DataIC50:  0.316nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417875(CHEMBL1668063)
Affinity DataIC50:  0.316nMAssay Description:Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417888(CHEMBL1668078)
Affinity DataIC50:  0.316nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414612(CHEMBL559115)
Affinity DataIC50:  0.316nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414608(CHEMBL550933)
Affinity DataIC50:  0.316nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414615(CHEMBL559942)
Affinity DataIC50:  0.398nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414613(CHEMBL561475)
Affinity DataIC50:  0.398nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417891(CHEMBL1668081)
Affinity DataIC50:  0.501nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417887(CHEMBL1668077)
Affinity DataIC50:  0.501nMAssay Description:Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414606(CHEMBL550258)
Affinity DataIC50:  0.501nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414618(CHEMBL563595)
Affinity DataIC50:  0.794nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414614(CHEMBL561276)
Affinity DataIC50:  0.794nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataIC50:  1nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataIC50:  1nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataIC50:  1nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataIC50:  1.17nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411047(CHEMBL211441)
Affinity DataIC50:  1.20nMAssay Description:Agonist activity at GR assessed as NF-kappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411047(CHEMBL211441)
Affinity DataIC50:  1.20nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataIC50:  1.20nMAssay Description:Agonist activity at GR assessed as NF-kappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cellsChecked by AuthorMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417876(CHEMBL1668064)
Affinity DataIC50:  1.26nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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