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Found 125 with Last Name = 'moormann' and Initial = 'ae'
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181844((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 4-amin...)
Affinity DataKi:  0.183nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181840((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-Meth...)
Affinity DataKi:  0.183nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181845((1S,7aS)-1-{[(4-amino-5-chloro-2-methoxybenzoyl)am...)
Affinity DataKi:  0.350nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181837((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181842((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 5-Fluo...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181841((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1H-ind...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181836(4-Amino-N-(1-aza-tricyclo[3.3.1.0*3,7*]non-4-yl)-5...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181839(CHEMBL202434 | N-exo-((4S,7alphaS)-tetrahydro-1H-p...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181840((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-Meth...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005833((exo)4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-yl...)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181843(CHEMBL201414 | cis-N-[(hexahydro-1H-pyrrolizin-l-y...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181842((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 5-Fluo...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181843(CHEMBL201414 | cis-N-[(hexahydro-1H-pyrrolizin-l-y...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181837((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181838(4-amino-5-chloro-2-ethoxy-N-[(1S,7aS)-hexahydro-1H...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181836(4-Amino-N-(1-aza-tricyclo[3.3.1.0*3,7*]non-4-yl)-5...)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181844((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 4-amin...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005841((exo) 4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-y...)
Affinity DataKi:  66nMAssay Description:Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Affinity DataKi:  134nMAssay Description:Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181841((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1H-ind...)
Affinity DataKi:  135nMAssay Description:Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005833((exo)4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-yl...)
Affinity DataKi:  152nMAssay Description:Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181839(CHEMBL202434 | N-exo-((4S,7alphaS)-tetrahydro-1H-p...)
Affinity DataKi:  259nMAssay Description:Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/2B/2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Affinity DataIC50:  6.10nMAssay Description:Binding affinity to 5HT2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Affinity DataIC50:  30nMAssay Description:Binding affinity to adrenergic alpha-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104649(7-(2-Nitro-ethyl)-azepan-(2Z)-ylideneamine | CHEMB...)
Affinity DataIC50:  152nMAssay Description:Inhibition of inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Affinity DataIC50:  227nMAssay Description:Binding affinity to dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104649(7-(2-Nitro-ethyl)-azepan-(2Z)-ylideneamine | CHEMB...)
Affinity DataIC50:  339nMAssay Description:Inhibition of Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50064011(7-Butyl-azepan-(2Z)-ylideneamine; hydrochloride | ...)
Affinity DataIC50:  517nMAssay Description:Inhibition of inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104654(2-(2-Amino-ethyl)-7-imino-azepane | CHEMBL92475)
Affinity DataIC50:  701nMAssay Description:Inhibition of inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50064011(7-Butyl-azepan-(2Z)-ylideneamine; hydrochloride | ...)
Affinity DataIC50:  850nMAssay Description:Inhibition of Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104655(((E)-7-But-2-enyl)-azepan-(2Z)-ylideneamine | CHEM...)
Affinity DataIC50:  890nMAssay Description:Inhibition of inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104654(2-(2-Amino-ethyl)-7-imino-azepane | CHEMBL92475)
Affinity DataIC50:  932nMAssay Description:Inhibition of Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104648(3-(2-Nitro-ethyl)-[1,4]oxazepan-(5Z)-ylideneamine ...)
Affinity DataIC50:  979nMAssay Description:Inhibition of inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Affinity DataIC50:  1.70E+3nMAssay Description:Binding affinity to dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50049257(Azepan-(2Z)-ylideneamine | CHEMBL315857 | CHEMBL54...)
Affinity DataIC50:  2.06E+3nMAssay Description:Inhibition of inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104656(3-Butyl-[1,4]oxazepan-(5Z)-ylideneamine | CHEMBL89...)
Affinity DataIC50:  2.43E+3nMAssay Description:Inhibition of inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104653(CHEMBL88308 | [1,4]Thiazepan-(5E)-ylideneamine | [...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104649(7-(2-Nitro-ethyl)-azepan-(2Z)-ylideneamine | CHEMB...)
Affinity DataIC50:  2.77E+3nMAssay Description:Inhibition of endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104655(((E)-7-But-2-enyl)-azepan-(2Z)-ylideneamine | CHEM...)
Affinity DataIC50:  3.39E+3nMAssay Description:Inhibition of Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50049257(Azepan-(2Z)-ylideneamine | CHEMBL315857 | CHEMBL54...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005841((exo) 4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-y...)
Affinity DataIC50:  3.90E+3nMAssay Description:Binding affinity to dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Affinity DataIC50:  4.50E+3nMAssay Description:Binding affinity to adrenergic alpha-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181838(4-amino-5-chloro-2-ethoxy-N-[(1S,7aS)-hexahydro-1H...)
Affinity DataIC50:  5.30E+3nMAssay Description:Binding affinity to dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104648(3-(2-Nitro-ethyl)-[1,4]oxazepan-(5Z)-ylideneamine ...)
Affinity DataIC50:  6.24E+3nMAssay Description:Inhibition of Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104651(3-(2-Amino-ethyl)-5-imino-[1,4]oxazepane | CHEMBL8...)
Affinity DataIC50:  6.66E+3nMAssay Description:Inhibition of inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104653(CHEMBL88308 | [1,4]Thiazepan-(5E)-ylideneamine | [...)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104651(3-(2-Amino-ethyl)-5-imino-[1,4]oxazepane | CHEMBL8...)
Affinity DataIC50:  8.39E+3nMAssay Description:Inhibition of Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50104657(((E)-3-But-2-enyl)-[1,4]oxazepan-(5Z)-ylideneamine...)
Affinity DataIC50:  9.26E+3nMAssay Description:Inhibition of inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50049249(Azocan-(2Z)-ylideneamine | CHEMBL329431)
Affinity DataIC50:  9.98E+3nMAssay Description:Inhibition of inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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