Affinity DataIC50: 0.100nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Src protein tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 10(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: 0.398nMAssay Description:Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in p...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Brutons tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
Affinity DataIC50: 0.460nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
Affinity DataIC50: 0.520nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.560nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£ga/Boehringer Ingelheim Research Inc.
Curated by ChEMBL
Bio-M£ga/Boehringer Ingelheim Research Inc.
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
Affinity DataIC50: 0.660nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.660nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.670nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£ga/Boehringer Ingelheim Research Inc.
Curated by ChEMBL
Bio-M£ga/Boehringer Ingelheim Research Inc.
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
Affinity DataIC50: 0.840nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.880nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of cathepsin S-mediated antigen presentation in B/T hybridoma cells assessed as IL-2 levelMore data for this Ligand-Target Pair
Affinity DataIC50: 0.960nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.960nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.980nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£ga/Boehringer Ingelheim Research Inc.
Curated by ChEMBL
Bio-M£ga/Boehringer Ingelheim Research Inc.
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 10(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 10(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flu...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 10(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...More data for this Ligand-Target Pair