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Found 210 with Last Name = 'nagatomi' and Initial = 'y'
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29986(arylpyrazole, 31)
Affinity DataIC50:  0.520nM EC50:  0.310nMAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50239749(2-(4-(6-chloro-2-(3-methylpentan-3-ylthio)-3H-benz...)
Affinity DataIC50:  0.660nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29985(arylpyrazole, 30)
Affinity DataIC50:  1.10nM EC50:  1.20nMAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50239749(2-(4-(6-chloro-2-(3-methylpentan-3-ylthio)-3H-benz...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Mus musculus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273899(CHEMBL456823 | tert-Butyl-4-[1-(2-fuluoropyridine-...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50373360(CHEMBL263917)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50373360(CHEMBL263917)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301542(4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50373365(CHEMBL258710)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301541(CHEMBL577729 | N-(4-(6-aminopyrimidin-4-yl)thiazol...)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50373362(CHEMBL263919)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29983(arylpyrazole, 28)
Affinity DataIC50:  2.5nM EC50:  1nMAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301816(2-cyclopropyl-5-(5-methyl-1-(pyridin-3-yl)-1H-1,2,...)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273898(CHEMBL452618 | tert-Butyl-4-[1-(2-fuluoropyridine-...)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Mus musculus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273942(4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataIC50:  3.10nMAssay Description:Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Mus musculus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273941(CHEMBL456196 | iso-Propyl-4-[1-(2-fuluoropyridine-...)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301821(2-ethyl-5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,...)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50239745(2-(4-(6-chloro-2-(pentan-3-ylthio)-3H-benzo[d]imid...)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301824(2-cyclopropyl-5-(1-(2-fluoropyridin-3-yl)-5-methyl...)
Affinity DataIC50:  3.5nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301822(5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataIC50:  3.60nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301804(5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazo...)
Affinity DataIC50:  3.60nMAssay Description:Antagonist activity at rat mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FLIP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301543(CHEMBL566374 | N-(4-(6-(ethylamino)pyrimidin-4-yl)...)
Affinity DataIC50:  3.70nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50373364(CHEMBL263903)
Affinity DataIC50:  3.90nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29974(arylpyrazole, 19)
Affinity DataIC50:  4nM EC50:  4.70nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50373369(CHEMBL259452)
Affinity DataIC50:  4.70nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301818(6-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-triazol-4-yl...)
Affinity DataIC50:  4.90nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301520(4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)th...)
Affinity DataIC50:  5.10nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301823(5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataIC50:  5.5nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50373362(CHEMBL263919)
Affinity DataIC50:  5.60nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273942(4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataIC50:  5.60nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273942(4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataIC50:  5.80nMAssay Description:Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50373373(CHEMBL260820)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301532(4-fluoro-N-methyl-N-(4-(pyridin-2-yl)thiazol-2-yl)...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273829(CHEMBL461673 | tert-Butyl-4-[1-(2-fluorophenyl)-1H...)
Affinity DataIC50:  6.30nMAssay Description:Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273899(CHEMBL456823 | tert-Butyl-4-[1-(2-fuluoropyridine-...)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273941(CHEMBL456196 | iso-Propyl-4-[1-(2-fuluoropyridine-...)
Affinity DataIC50:  7.20nMAssay Description:Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29981(arylpyrazole, 26)
Affinity DataIC50:  8.20nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50373365(CHEMBL258710)
Affinity DataIC50:  9.10nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29984(arylpyrazole, 29)
Affinity DataIC50:  9.30nM EC50:  4.5nMAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50239745(2-(4-(6-chloro-2-(pentan-3-ylthio)-3H-benzo[d]imid...)
Affinity DataIC50:  9.70nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273828(CHEMBL511355 | tert-Butyl-4-(1-phenyl-1H-1,2,3-tri...)
Affinity DataIC50:  9.80nMAssay Description:Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301534(4-fluoro-N-methyl-N-(4-(pyrimidin-4-yl)thiazol-2-y...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50373364(CHEMBL263903)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29973(arylpyrazole, 18)
Affinity DataIC50:  11nM EC50:  12nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301815(2,2-dimethyl-5-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273864(CHEMBL511352 | tert-Butyl-4-[1-(2-methylphenyl)-1H...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29982(arylpyrazole, 27)
Affinity DataIC50:  11nM EC50:  7.10nMAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Mus musculus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273898(CHEMBL452618 | tert-Butyl-4-[1-(2-fuluoropyridine-...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29977(arylpyrazole, 22)
Affinity DataIC50:  13nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50373366(CHEMBL258711)
Affinity DataIC50:  15nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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