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Found 33 with Last Name = 'ojeda' and Initial = 'i'
TargetORF1a(Middle East respiratory syndrome coronavirus (Viru...)
University Of Illinois At Chicago

LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataKi:  7.60E+3nM IC50:  6.20E+3nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University Of Illinois At Chicago

LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataKi:  1.15E+4nM IC50:  1.09E+4nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50523945(CHEMBL4475926)
Affinity DataKi:  3.66E+4nMAssay Description:Competitive-inhibition of MERS-CoV papain-like protease using varying levels of Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50523946(ONO-1078)
Affinity DataKi:  1.27E+5nMAssay Description:Competitive-inhibition of MERS-CoV papain-like protease using varying levels of Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University Of Illinois At Chicago

LigandPNGBDBM31524(5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...)
Affinity DataIC50:  230nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University Of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50:  980nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University Of Illinois At Chicago

LigandPNGBDBM31530(2-methyl-5-[(methylamino)methyl]-N-[(1R)-1-(naphth...)
Affinity DataIC50:  1.18E+3nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University Of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50:  1.20E+3nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University Of Illinois At Chicago

LigandPNGBDBM154574(N-(2H-1,3-benzodioxol-5-ylmethyl)-1-[(1S)-1-(napht...)
Affinity DataIC50:  2.26E+3nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50523945(CHEMBL4475926)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50523946(ONO-1078)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50001908(1-(4-Nitro-phenyl)-piperazine | CHEMBL165012)
Affinity DataIC50:  7.16E+4nMAssay Description:Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C Virus (Virus))
University Of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: >1.00E+5nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C Virus (Virus))
University Of Illinois At Chicago

LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataIC50: >1.00E+5nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotase(Bacillus anthracis (Firmicute))
University Of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: >1.00E+5nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotase(Bacillus anthracis (Firmicute))
University Of Illinois At Chicago

LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataIC50: >1.00E+5nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetORF1a(Middle East respiratory syndrome coronavirus (Viru...)
University Of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: >1.00E+5nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50523947(CHEMBL4447423)
Affinity DataIC50:  1.37E+5nMAssay Description:Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50523948(CHEBI:78878 | CHEMBL1743207)
Affinity DataIC50:  1.41E+5nMAssay Description:Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50523949(4-Nitrocatechol | CHEBI:16318)
Affinity DataIC50:  1.45E+5nMAssay Description:Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50192743(3,4-Dihydroxybenzaldehyde | CHEBI:50205 | Protocat...)
Affinity DataIC50:  2.39E+5nMAssay Description:Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50384265(CHEMBL2030452)
Affinity DataKd:  7.60E+3nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM97231(2-[(E)-2-(4-morpholin-4-ylphenyl)ethenyl]quinoline...)
Affinity DataKd:  7.60E+3nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50192743(3,4-Dihydroxybenzaldehyde | CHEBI:50205 | Protocat...)
Affinity DataKd:  2.20E+5nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50523945(CHEMBL4475926)
Affinity DataKd:  7.60E+3nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50523950(CHEMBL1368663)
Affinity DataKd:  7.60E+3nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50103596((E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phen...)
Affinity DataKd:  7.60E+3nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50523946(ONO-1078)
Affinity DataKd:  1.41E+4nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetORF1a(Middle East respiratory syndrome coronavirus (Viru...)
University Of Illinois At Chicago

LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataKd:  1.84E+4nMpH: 7.4Assay Description:Each PLpro enzyme was immobilized on a CM5 sensor chip using standard aminecoupling with running buffer HBS-P (10 mM HEPES, 150 mM NaCl, 0.05% surfac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University Of Illinois At Chicago

LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataKd:  2.63E+4nMpH: 7.4Assay Description:Each PLpro enzyme was immobilized on a CM5 sensor chip using standard aminecoupling with running buffer HBS-P (10 mM HEPES, 150 mM NaCl, 0.05% surfac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetORF1a(Middle East respiratory syndrome coronavirus (Viru...)
University Of Illinois At Chicago

LigandPNGBDBM154575(3-chloro-N-[5-(7-ethoxy-1-benzofuran-2-yl)-1,3,4-o...)
Affinity DataKd:  3.99E+4nMpH: 7.4Assay Description:Each PLpro enzyme was immobilized on a CM5 sensor chip using standard aminecoupling with running buffer HBS-P (10 mM HEPES, 150 mM NaCl, 0.05% surfac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University Of Illinois At Chicago

LigandPNGBDBM154575(3-chloro-N-[5-(7-ethoxy-1-benzofuran-2-yl)-1,3,4-o...)
Affinity DataKd:  3.14E+4nMpH: 7.4Assay Description:Each PLpro enzyme was immobilized on a CM5 sensor chip using standard aminecoupling with running buffer HBS-P (10 mM HEPES, 150 mM NaCl, 0.05% surfac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50523944(CHEMBL4544405)
Affinity DataKd:  7.60E+3nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed