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Found 326 with Last Name = 'paralkar' and Initial = 'v'
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181274(5-(3-((S)-2-((R)-4-(3-chlorophenyl)-3-hydroxybutyl...)
Affinity DataIC50:  1.10nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM35847((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP2 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM35847((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of rat EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataIC50:  6nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167427(CHEMBL3800397)
Affinity DataIC50:  6nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167428(CHEMBL3797264)
Affinity DataIC50:  6nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167429(CHEMBL3799301)
Affinity DataIC50:  6nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346031(6-{4-Cyano-3-[(R)-2-hydroxy-3-(2-indan-2-yl-1,1-di...)
Affinity DataIC50:  6nMAssay Description:Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167538(CHEMBL3799331)
Affinity DataIC50:  7nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50233990(CHEMBL4104957)
Affinity DataIC50:  7nMAssay Description:Inhibition of TPH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167426(CHEMBL3798045)
Affinity DataIC50:  8nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167424(CHEMBL3799287)
Affinity DataIC50:  10nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167425(CHEMBL3799810)
Affinity DataIC50:  10nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167398(CHEMBL3798880)
Affinity DataIC50:  11nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167399(CHEMBL3800151)
Affinity DataIC50:  11nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167537(CHEMBL3799498)
Affinity DataIC50:  11nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167820(CHEMBL3797282)
Affinity DataIC50:  11nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50234204(CHEMBL4077986)
Affinity DataIC50:  11nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167536(CHEMBL3799767)
Affinity DataIC50:  12nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167757(CHEMBL3797766)
Affinity DataIC50:  13nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167397(CHEMBL3799918)
Affinity DataIC50:  14nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167509(CHEMBL3797417)
Affinity DataIC50:  14nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50234218(CHEMBL4086156)
Affinity DataIC50:  14nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167395(CHEMBL3799737)
Affinity DataIC50:  15nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167396(CHEMBL3799711)
Affinity DataIC50:  15nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167821(CHEMBL3797220)
Affinity DataIC50:  15nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145648(LP-778902 | LX1032 | LX1606 | Telotristat | Xermel...)
Affinity DataIC50:  16nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145648(LP-778902 | LX1032 | LX1606 | Telotristat | Xermel...)
Affinity DataIC50:  16nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167394(CHEMBL3798405)
Affinity DataIC50:  16nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167508(CHEMBL3797520)
Affinity DataIC50:  16nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167826(CHEMBL3798995)
Affinity DataIC50:  16nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181289(5-(3-((S)-2-(4-(3-fluorophenyl)-3-hydroxybutyl)-5-...)
Affinity DataIC50:  17nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167507(CHEMBL3799404)
Affinity DataIC50:  18nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346032(6-[2-((R)-1-{(R)-3-[2-(3-Chloro-4-methyl-phenyl)-1...)
Affinity DataIC50:  18nMAssay Description:Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167801(CHEMBL3799259)
Affinity DataIC50:  19nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50234203(CHEMBL4064649)
Affinity DataIC50:  19nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167547(CHEMBL3800237)
Affinity DataIC50:  20nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50233988(CHEMBL4097252)
Affinity DataIC50:  20nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181296(5-(3-((S)-2-(3-hydroxy-4-phenylbutyl)-5-oxopyrroli...)
Affinity DataIC50:  21nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50142488(7-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)phen...)
Affinity DataIC50:  21nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50234202(CHEMBL4072840)
Affinity DataIC50:  21nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181279(7-(2-(4-(3-chlorophenyl)-3-hydroxybutyl)-5-oxopyrr...)
Affinity DataIC50:  22nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167822(CHEMBL3800114)
Affinity DataIC50:  22nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167506(CHEMBL3799132)
Affinity DataIC50:  22nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50233987(CHEMBL4084634)
Affinity DataIC50:  22nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50234217(CHEMBL4104549)
Affinity DataIC50:  22nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161093((R)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthale...)
Affinity DataIC50:  23nMAssay Description:Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cellsMore data for this Ligand-Target Pair
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346033(6-(4-Cyano-3-{(R)-3-[2-(3-fluoro-4-methyl-phenyl)-...)
Affinity DataIC50:  23nMAssay Description:Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50234201(CHEMBL4078797)
Affinity DataIC50:  23nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50234211(CHEMBL4079227)
Affinity DataIC50:  23nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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