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Found 57 with Last Name = 'pupi' and Initial = 'a'
TargetIntegrin alpha-V(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50235980(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  0.130nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta5 receptor in human placenta by microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetIntegrin alpha-V(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50276748(CHEMBL460012 | [(1R,3S,9S,11S,14R)-9-(3-Guanidino-...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta5 receptor in human placenta by microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233956(CHEMBL4075011)
Affinity DataIC50:  1.20nMAssay Description:Displacement of biotinylated vitronectin from recombinant human integrin alphaVbeta3 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PDGFRbeta (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50237601(CHEMBL411941 | CycloRGDfV | [(2S,5R,8S,11S)-5-Benz...)
Affinity DataIC50:  3.20nMAssay Description:Displacement of biotinylated vitronectin from human integrin alphaVbeta3 measured after 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233954(CHEMBL4066412)
Affinity DataIC50:  3.80nMAssay Description:Displacement of biotinylated vitronectin from recombinant human integrin alphaVbeta3 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233955(CHEMBL4095441)
Affinity DataIC50:  5.10nMAssay Description:Displacement of biotinylated vitronectin from recombinant human integrin alphaVbeta3 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50276748(CHEMBL460012 | [(1R,3S,9S,11S,14R)-9-(3-Guanidino-...)
Affinity DataIC50:  5.64nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta3 receptor in human placenta by microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233958(CHEMBL4087743)
Affinity DataIC50:  6.10nMAssay Description:Displacement of biotinylated vitronectin from human integrin alphaVbeta3 measured after 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50276747(CHEMBL443362 | c[RGDf-(3R)-Carboxymorpholine])
Affinity DataIC50:  6.5nMAssay Description:Displacement of [125I] echistatin from alphaVbeta3 integrin isolated from human placenta after 3 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233954(CHEMBL4066412)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant human PDGFRbeta expressed in insect cells using Ulight-Poly GAT[EAY(1:1:1)]n as substrate measured after 30 mins by LANCE m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50276746(CHEMBL452724 | c[RGDf-(3S)-Carboxymorpholine])
Affinity DataIC50:  15.1nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta5 receptor in human placenta by microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50235980(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  18.9nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta3 receptor in human placenta by microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetIntegrin alpha-V(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50276747(CHEMBL443362 | c[RGDf-(3R)-Carboxymorpholine])
Affinity DataIC50:  21nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta5 receptor in human placenta by microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233956(CHEMBL4075011)
Affinity DataIC50:  31nMAssay Description:Displacement of biotinylated fibronectin from recombinant human integrin alpha5beta1 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50276747(CHEMBL443362 | c[RGDf-(3R)-Carboxymorpholine])
Affinity DataIC50:  32.6nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta3 receptor in human placenta by microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50389204(CHEMBL2062977)
Affinity DataIC50:  48nMAssay Description:Displacement of [125I] echistatin from alphaVbeta3 integrin isolated from human placenta after 3 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  80nMAssay Description:Inhibition of VEGFR2 (unknown origin) phosphorylationMore data for this Ligand-Target Pair
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233954(CHEMBL4066412)
Affinity DataIC50:  96nMAssay Description:Displacement of biotinylated fibronectin from recombinant human integrin alpha5beta1 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233955(CHEMBL4095441)
Affinity DataIC50:  101nMAssay Description:Displacement of biotinylated fibronectin from recombinant human integrin alpha5beta1 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233958(CHEMBL4087743)
Affinity DataIC50:  152nMAssay Description:Inhibition of alpha5beta1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50276746(CHEMBL452724 | c[RGDf-(3S)-Carboxymorpholine])
Affinity DataIC50:  157nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta3 receptor in human placenta by microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233958(CHEMBL4087743)
Affinity DataIC50:  315nMAssay Description:Displacement of biotinylated vitronectin from human integrin alphaVbeta5 measured after 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233954(CHEMBL4066412)
Affinity DataIC50:  420nMAssay Description:Inhibition of recombinant human VEGFR2 expressed in Sf9 cells using Ulight-CAGAGAIETDKEYYTVKD as substrate measured after 60 mins by LANCE methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233956(CHEMBL4075011)
Affinity DataIC50:  500nMAssay Description:Inhibition of vitronectin binding to alphaVbeta3 in human EPC in presence of MnCl2 measured after 30 mins by crystal violet staining based cell adhes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233954(CHEMBL4066412)
Affinity DataIC50:  500nMAssay Description:Inhibition of vitronectin binding to alphaVbeta3 in human EPC in presence of MnCl2 measured after 30 mins by crystal violet staining based cell adhes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327751((S)-3-{2-[4-(3-Guanidinopropyl)[1,2,3]triazol-1-yl...)
Affinity DataIC50:  1.02E+3nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327755((S)-3-(2-{4-[2-(4-Carbamimidoylpiperazin-1-yl)ethy...)
Affinity DataIC50:  1.27E+3nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327751((S)-3-{2-[4-(3-Guanidinopropyl)[1,2,3]triazol-1-yl...)
Affinity DataIC50:  1.35E+3nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327749((S)-3-[2-(4-Guanidinomethyl[1,2,3]triazol-1-yl)ace...)
Affinity DataIC50:  1.78E+3nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233959(CHEMBL4093704)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of vitronectin binding to alphaVbeta3 in human EPC in presence of MnCl2 measured after 30 mins by crystal violet staining based cell adhes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327753((R)-3-(2-{4-[2-(4-Carbamimidoylpiperazin-1-yl)ethy...)
Affinity DataIC50:  2.42E+3nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50260163(CHEMBL4094980)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of BACE1 (unknown origin) pre-incubated for 10 mins before addition of fluorescent substrate HiLyte FluorTM 488-Glu-Val-Asn-Leu-Asp-Ala-Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327750((S)-3-{2-[4-(2-Guanidinoethyl)[1,2,3]triazol-1-yl]...)
Affinity DataIC50:  3.47E+3nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327750((S)-3-{2-[4-(2-Guanidinoethyl)[1,2,3]triazol-1-yl]...)
Affinity DataIC50:  4.38E+3nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327753((R)-3-(2-{4-[2-(4-Carbamimidoylpiperazin-1-yl)ethy...)
Affinity DataIC50:  4.96E+3nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327746((R)-3-[2-(4-Guanidinomethyl[1,2,3]triazol-1-yl)ace...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327745(CHEMBL1257627 | [(2-{4-[2-(4-Carbamimidoylpiperazi...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327744(({2-[4-(3-Guanidinopropyl)[1,2,3]triazol-1-yl]acet...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327743(({2-[4-(2-Guanidinoethyl)[1,2,3]triazol-1-yl]acety...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327742(CHEMBL1257508 | {[2-(4-Guanidinomethyl[1,2,3]triaz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327747((R)-3-{2-[4-(2-Guanidinoethyl)[1,2,3]triazol-1-yl]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327748((R)-3-{2-[4-(3-Guanidinopropyl)[1,2,3]triazol-1-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327749((S)-3-[2-(4-Guanidinomethyl[1,2,3]triazol-1-yl)ace...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327752((R)-3-{2-[4-(4-Carbamimidoylpiperazin-1-ylmethyl)[...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233955(CHEMBL4095441)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of vitronectin binding to alphaVbeta3 in human EPC in presence of MnCl2 measured after 30 mins by crystal violet staining based cell adhes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327754((S)-3-{2-[4-(4-Carbamimidoylpiperazin-1-ylmethyl)[...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327754((S)-3-{2-[4-(4-Carbamimidoylpiperazin-1-ylmethyl)[...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327752((R)-3-{2-[4-(4-Carbamimidoylpiperazin-1-ylmethyl)[...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327747((R)-3-{2-[4-(2-Guanidinoethyl)[1,2,3]triazol-1-yl]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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