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Found 325 with Last Name = 'reifenberg' and Initial = 'e'
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356214(CHEMBL1910471)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356215(CHEMBL1910473)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356209(CHEMBL1910466)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356210(CHEMBL1910467)
Affinity DataIC50:  1nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356208(CHEMBL1910465)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259007((R)-2-(4'-((4-isobutyrylphenoxy)methyl)biphenyl-4-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259007((R)-2-(4'-((4-isobutyrylphenoxy)methyl)biphenyl-4-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356218(CHEMBL1910476)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356222(CHEMBL1910648)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356206(CHEMBL1910459)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356216(CHEMBL1910474)
Affinity DataIC50:  2nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356221(CHEMBL1910647)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259009((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356219(CHEMBL1910649)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356220(CHEMBL1910650)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356203(CHEMBL1910472)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258875((R)-2-(4'-((4-(4-fluorobenzoyl)phenoxy)methyl)biph...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24047((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50:  4nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24047((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50:  4.40nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356213(CHEMBL1910470)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356207(CHEMBL1910460)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258917((R)-2-(4'-((4-(cyclohexanecarbonyl)phenoxy)methyl)...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356204(CHEMBL1910453)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259009((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50258875((R)-2-(4'-((4-(4-fluorobenzoyl)phenoxy)methyl)biph...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356205(CHEMBL1910458)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356242(CHEMBL1910461)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356217(CHEMBL1910475)
Affinity DataIC50:  12nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50258917((R)-2-(4'-((4-(cyclohexanecarbonyl)phenoxy)methyl)...)
Affinity DataIC50:  15nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM24047((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50:  28nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258875((R)-2-(4'-((4-(4-fluorobenzoyl)phenoxy)methyl)biph...)
Affinity DataIC50:  80nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM24042((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50:  86nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258917((R)-2-(4'-((4-(cyclohexanecarbonyl)phenoxy)methyl)...)
Affinity DataIC50:  90nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259007((R)-2-(4'-((4-isobutyrylphenoxy)methyl)biphenyl-4-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259010((R)-2-(3-fluoro-4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50:  180nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258873((R)-3-methyl-2-(4'-((3-methylquinolin-2-yloxy)meth...)
Affinity DataIC50:  200nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258874((R)-2-(4'-((2,8-bis(trifluoromethyl)quinolin-3-ylo...)
Affinity DataIC50:  200nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258875((R)-2-(4'-((4-(4-fluorobenzoyl)phenoxy)methyl)biph...)
Affinity DataIC50:  220nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259052((R)-2-(4'-((4-benzoylphenoxy)methyl)biphenyl-4-yls...)
Affinity DataIC50:  230nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259009((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50:  230nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50356203(CHEMBL1910472)
Affinity DataIC50:  310nMAssay Description:Inhibition of aggrecanase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256157(CHEMBL481894 | N-((5-chloro-8-hydroxyquinolin-7-yl...)
Affinity DataIC50:  350nMAssay Description:Inhibition of ADAMTS5 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM24040((2R)-2-({4-[4-(1-benzofuran-2-ylcarbonyloxy)phenyl...)
Affinity DataIC50:  350nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM24040((2R)-2-({4-[4-(1-benzofuran-2-ylcarbonyloxy)phenyl...)
Affinity DataIC50:  350nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259546((R)-3-methyl-2-(4'-((4-phenoxyphenoxy)methyl)biphe...)
Affinity DataIC50:  400nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM24046((2R)-2-[(4-{4-[(E)-2-(1-benzofuran-2-yl)ethenyl]ph...)
Affinity DataIC50:  400nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50356222(CHEMBL1910648)
Affinity DataIC50:  400nMAssay Description:Inhibition of aggrecanase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258872((R)-3-methyl-2-(4'-((quinolin-2-yloxy)methyl)biphe...)
Affinity DataIC50:  400nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50356223(CHEMBL1910651)
Affinity DataIC50:  420nMAssay Description:Inhibition of aggrecanase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50356224(CHEMBL1910449)
Affinity DataIC50:  420nMAssay Description:Inhibition of aggrecanase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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