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Found 464 with Last Name = 'rennie' and Initial = 'gr'
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50385150(CHEMBL2035650)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of HPGDSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50385142(CHEMBL2035651)
Affinity DataIC50:  2.34nMAssay Description:Inhibition of human recombinant HPGDS using PGH2 as substrate assessed as production of PGD2 preincubated for 10 mins prior substrate addition measur...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323438(4-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureido)-1H-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM26514(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323416(2-acetamido-N-(3-(3-tert-butyl-5-(3-phenylureido)-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323438(4-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureido)-1H-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM26514(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  6.70nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  8nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50385144(CHEMBL2035653)
Affinity DataIC50:  8.26nMAssay Description:Inhibition of human recombinant HPGDS using PGH2 as substrate assessed as production of PGD2 preincubated for 10 mins prior substrate addition measur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM26514(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  11.5nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  13.6nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323437((1R)-6-(3-(3-tert-butyl-5-(3-phenylureido)-1H-pyra...)
Affinity DataIC50:  14nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323427(CHEMBL1209482 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  16nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  16.8nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323420(CHEMBL1209343 | N-(2-(3-(3-tert-butyl-5-(3-phenylu...)
Affinity DataIC50:  18nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323431(CHEMBL1209564 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  27.9nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323435((1R)-2-(3-(3-tert-butyl-5-(3-phenylureido)-1H-pyra...)
Affinity DataIC50:  30nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323416(2-acetamido-N-(3-(3-tert-butyl-5-(3-phenylureido)-...)
Affinity DataIC50:  34nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323433(4-(3-(3-tert-butyl-5-(3-phenylureido)-1H-pyrazol-1...)
Affinity DataIC50:  37nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323419(CHEMBL1209342 | N-(2-(3-(3-tert-butyl-5-(3-phenylu...)
Affinity DataIC50:  38nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323434(4-(3-(3-tert-butyl-5-(3-phenylureido)-1H-pyrazol-1...)
Affinity DataIC50:  39nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323430(CHEMBL1209563 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  48.8nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323418(CHEMBL1209276 | N-(2-(3-(3-tert-butyl-5-(3-phenylu...)
Affinity DataIC50:  51nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323436((1R)-2-(3-(3-tert-butyl-5-(3-phenylureido)-1H-pyra...)
Affinity DataIC50:  57nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323427(CHEMBL1209482 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  63nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323415(CHEMBL1209273 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  68nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323425(CHEMBL1209407 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  68nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323432(CHEMBL1209565 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  78.2nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323420(CHEMBL1209343 | N-(2-(3-(3-tert-butyl-5-(3-phenylu...)
Affinity DataIC50:  88nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323423(CHEMBL1209405 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  108nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323429(CHEMBL1209484 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  132nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323430(CHEMBL1209563 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  135nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM26515(1-[4-(cyclopentylamino)-2-{[2-methoxy-4-(4-methylp...)
Affinity DataIC50:  145nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323421(2-acetamido-N-(3-(3-tert-butyl-5-(3-phenylureido)-...)
Affinity DataIC50:  168nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323417(CHEMBL1209275 | N-(2-(3-(3-tert-butyl-5-(3-phenylu...)
Affinity DataIC50:  169nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323413(2-amino-N-(3-(3-tert-butyl-5-(3-phenylureido)-1H-p...)
Affinity DataIC50:  176nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323414(CHEMBL1209214 | methyl 2-(3-(3-tert-butyl-5-(3-phe...)
Affinity DataIC50:  176nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323426(CHEMBL1209481 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  185nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323431(CHEMBL1209564 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  201nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323418(CHEMBL1209276 | N-(2-(3-(3-tert-butyl-5-(3-phenylu...)
Affinity DataIC50:  205nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323424(2-acetamido-N-(3-(3-tert-butyl-5-(3-phenylureido)-...)
Affinity DataIC50:  211nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323428(CHEMBL1209483 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  231nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323419(CHEMBL1209342 | N-(2-(3-(3-tert-butyl-5-(3-phenylu...)
Affinity DataIC50:  243nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50385143(CHEMBL2035652)
Affinity DataIC50:  274nMAssay Description:Inhibition of human recombinant HPGDS using PGH2 as substrate assessed as production of PGD2 preincubated for 10 mins prior substrate addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50385149(CHEMBL2035649)
Affinity DataIC50:  280nMAssay Description:Inhibition of HPGDSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323414(CHEMBL1209214 | methyl 2-(3-(3-tert-butyl-5-(3-phe...)
Affinity DataIC50:  287nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323425(CHEMBL1209407 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  296nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323432(CHEMBL1209565 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  331nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323415(CHEMBL1209273 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  332nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM26516(1-[4-(cyclopentylamino)-2-{[4-(4-methylpiperazin-1...)
Affinity DataIC50:  345nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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