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Found 4149 with Last Name = 'rodriguez' and Initial = 'al'
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50104326(4-{3-(4-hydroxy-phenyl)-4-ethyl-5-[4-(2-piperidin-...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50104326(4-{3-(4-hydroxy-phenyl)-4-ethyl-5-[4-(2-piperidin-...)
Affinity DataKi:  0.360nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50104329(4-{3-Ethyl-5-phenyl-4-[4-(2-piperidin-1-yl-ethoxy)...)
Affinity DataKi:  0.430nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50104324(4-{5-(4-hydroxy-phenyl)-4-methyl-3-[4-(2-piperidin...)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(RAT)
Dvanderbilt Program In Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50403547(ATROPEN | ATROPINE)
Affinity DataKi:  0.520nMAssay Description:Displacement of [3H]NMS from rat recombinant muscarinic M4 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(RAT)
Dvanderbilt Program In Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50403547(ATROPEN | ATROPINE)
Affinity DataKi:  0.520nMAssay Description:Displacement of [3H]NMS from rat recombinant muscarinic M4 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50240552(CHEMBL195)
Affinity DataKi:  0.640nMAssay Description:Displacement of [3H]NMS from human recombinant muscarinic M4 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(RAT)
Dvanderbilt Program In Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50403547(ATROPEN | ATROPINE)
Affinity DataKi:  0.860nMAssay Description:Displacement of [3H]NMS from rat recombinant muscarinic M5 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258612(3-Fluoro-5-cyano-1-(2-methylthiazol-4-ylethynyl)be...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 (unknown origin) expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50104325(4-[5-(4-hydroxy-phenyl)-4-ethyl-3-(4-methoxy-pheny...)
Affinity DataKi:  0.910nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50160632(3-(6-Methyl-pyridin-2-ylethynyl)-benzonitrile | 3-...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]MPEP from rat brain recombinant mGluR5 expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50317854(5-((6-Methylpyridin-2-yl)ethynyl)nicotinonitrile |...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3HMPEP from rat cloned mGluR5 expressed in HEK293T cells by by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50104325(4-[5-(4-hydroxy-phenyl)-4-ethyl-3-(4-methoxy-pheny...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258611(1-Fluoro-3-(pyridin-3-yl)-5-(2-methylthiazol-4ylet...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 (unknown origin) expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258330(2-(4-Fluorophenyl)-5-(6-methylpyridin-2-ylethynyl)...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]MPEP from rat brain recombinant mGluR5 expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50104327(4-{5-(4-hydroxy-phenyl)-4-ethyl-3-[4-(2-piperidin-...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50104329(4-{3-Ethyl-5-phenyl-4-[4-(2-piperidin-1-yl-ethoxy)...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258328(2-Phenyl-5-(6-methylpyridin-2-ylethynyl)benzonitri...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]MPEP from rat brain recombinant mGluR5 expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50104323(4-{5-(4-hydroxy-phenyl)-4-propyl-3-[4-(2-piperidin...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50257064(CHEMBL2386850)
Affinity DataKi:  4.40nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]3methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50149801(2-Phenyl-5-(2-methylthiazol-4ylethynyl)pyridine | ...)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 (unknown origin) expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50149805(2-(Pyridin-3-yl)-5-(2-methylthiazol-4ylethynyl)pyr...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 (unknown origin) expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50442525(CHEMBL2440659 | US8796295, Table 2: Compound: 1)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5 receptor allosteric binding site (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50268390(CHEMBL4071900)
Affinity DataKi:  7.80nMAssay Description:Displacement of [3H]NMS from human recombinant muscarinic M4 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258665(3-Cyano-4-phenyl-N-(6-methylpyridin-2-yl)-benzamid...)
Affinity DataKi:  9.80nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 (unknown origin) expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258613(1-(Pyridin-3-yl)-2-fluoro-4-(2-methylthiazol-4ylet...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 (unknown origin) expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50149798(3-Phenyl-1-(2-methylthiazol-4-ylethynyl)benzene | ...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 (unknown origin) expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 (unknown origin) expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50122758(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Affinity DataKi:  16nMAssay Description:Displacement of [3HMPEP from rat cloned mGluR5 expressed in HEK293T cells by by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258329(2-(3-Fluorophenyl)-5-(6-methylpyridin-2-ylethynyl)...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]MPEP from rat brain recombinant mGluR5 expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50577263(CHEMBL4850236)
Affinity DataKi:  17nMAssay Description:Inhibition of human sigma1 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50104328(4-{4-Ethyl-5-phenyl-3-[4-(2-piperidin-1-yl-ethoxy)...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258331(3-Cyano-4'-(3-fluorophenyl)-N-(6-methylpyridin-2-y...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 (unknown origin) expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50342740(3-Cyano-4-(4-fluorophenyl)-N-(1-[2-chlorophenyl]-3...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]-MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50104324(4-{5-(4-hydroxy-phenyl)-4-methyl-3-[4-(2-piperidin...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50104323(4-{5-(4-hydroxy-phenyl)-4-propyl-3-[4-(2-piperidin...)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50047700(CHEMBL3314850)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGlu5 expressed in HEK293A cells after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50342738(3-Cyano-4-phenyl-N-(1-[2-chlorophenyl]-3-phenyl-1H...)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]-MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50596239(CHEMBL5189893)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]-NMS from human muscarinic acetylcholine M4 receptor expressed in CHO cell membrane by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50104328(4-{4-Ethyl-5-phenyl-3-[4-(2-piperidin-1-yl-ethoxy)...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50317850(5-(2-Methylquinolin-7-yl)-2-(4-fluorophenyl)benzon...)
Affinity DataKi:  64nMAssay Description:Displacement of [3HMPEP from rat cloned mGluR5 expressed in HEK293T cells by by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258619(3-Cyano-5-fluoro-N-(6-methylpyridin-2-yl)-benzamid...)
Affinity DataKi:  66nMAssay Description:Displacement of [3H]MPEP from rat brain recombinant mGluR5 expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258619(3-Cyano-5-fluoro-N-(6-methylpyridin-2-yl)-benzamid...)
Affinity DataKi:  66nMAssay Description:Displacement of [3H]-MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(RAT)
Dvanderbilt Program In Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50605085(CHEMBL5204021)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]-NMS from rat muscarinic M5 receptor stably expressed in CHO cells membrane by topCount scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258333(3-Cyano-N-(6-methylpyridin-2-yl)-4-(naphthalen-1-y...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]MPEP from rat brain recombinant mGluR5 expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50104327(4-{5-(4-hydroxy-phenyl)-4-ethyl-3-[4-(2-piperidin-...)
Affinity DataKi:  75nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50317856(5-(2-Methylquinolin-7-yl)-2-phenylnicotinonitrile ...)
Affinity DataKi:  97nMAssay Description:Displacement of [3HMPEP from rat cloned mGluR5 expressed in HEK293T cells by by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50317849(5-(2-Methylquinolin-7-yl)-2-phenylbenzonitrile | C...)
Affinity DataKi:  97nMAssay Description:Displacement of [3HMPEP from rat cloned mGluR5 expressed in HEK293T cells by by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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