Affinity DataKi: 0.100nMAssay Description:Compound was tested for inhibition of Sunflower beta-trypsinMore data for this Ligand-Target Pair
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataKi: 0.920nMAssay Description:Compound was tested for inhibition of Matriptase from human breast cancer cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Compound was tested for inhibition of bovine beta trypsinMore data for this Ligand-Target Pair
Affinity DataKi: 3nM ΔG°: -48.3kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Displacement of FAM-Bak from human Bcl-xL by FP assayMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Displacement of FAM-Bid from human Mcl1 by FP assayMore data for this Ligand-Target Pair
Affinity DataKi: 13nM ΔG°: -44.7kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Displacement of FAM-Bim peptide from human Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 18nMAssay Description:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 24nM ΔG°: -43.1kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
Affinity DataKi: 28nM ΔG°: -42.7kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
Affinity DataKi: 36nM ΔG°: -42.2kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
Affinity DataKi: 38nM ΔG°: -42.1kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
Affinity DataKi: 39nM ΔG°: -42.0kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
Affinity DataKi: 44nM ΔG°: -41.7kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
Affinity DataKi: 81nM ΔG°: -40.1kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
Affinity DataKi: 86nM ΔG°: -40.1kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataKi: 100nM ΔG°: -39.6kJ/molepH: 8.5 T: 2°CAssay Description:The enzyme reaction was initiated by adding fluorescence peptide substrate to reaction mixture containing enzyme and test compounds. The enzyme activ...More data for this Ligand-Target Pair
Affinity DataKi: 110nMAssay Description:Displacement of FAM-Bid BH3 peptide from human recombinant Bcl2 by FP-based binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 150nM ΔG°: -38.6kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 150nMAssay Description:Displacement of FAM-Bid BH3 peptide from human Mcl1 by FP-based binding assayMore data for this Ligand-Target Pair
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataKi: 160nM ΔG°: -38.4kJ/molepH: 8.5 T: 2°CAssay Description:The enzyme reaction was initiated by adding fluorescence peptide substrate to reaction mixture containing enzyme and test compounds. The enzyme activ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataKi: 170nMAssay Description:Compound was evaluated for the binding affinity against protein-tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
Affinity DataKi: 170nM ΔG°: -38.4kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Displacement of FAM-Bim peptide from human Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 180nMAssay Description:Displacement of FAM-Bid from human Mcl1 by FP assayMore data for this Ligand-Target Pair
Affinity DataKi: 180nM ΔG°: -38.1kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
Affinity DataKi: 220nM ΔG°: -37.6kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 260nMAssay Description:Displacement of FAM-Bid from human Mcl1 by FP assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 280nMAssay Description:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 290nM ΔG°: -36.9kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
Affinity DataKi: 290nM ΔG°: -36.9kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
Affinity DataKi: 290nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
Affinity DataKi: 320nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
Affinity DataKi: 340nMAssay Description:Displacement of FAM-Bim peptide from human Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 350nM ΔG°: -36.5kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataKi: 380nM ΔG°: -36.3kJ/molepH: 8.5 T: 2°CAssay Description:The enzyme reaction was initiated by adding fluorescence peptide substrate to reaction mixture containing enzyme and test compounds. The enzyme activ...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 400nMAssay Description:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataKi: 450nM ΔG°: -35.9kJ/molepH: 8.5 T: 2°CAssay Description:The enzyme reaction was initiated by adding fluorescence peptide substrate to reaction mixture containing enzyme and test compounds. The enzyme activ...More data for this Ligand-Target Pair
Affinity DataKi: 480nMAssay Description:Displacement of FAM-Bak from human Bcl-xL by FP assayMore data for this Ligand-Target Pair
Affinity DataKi: 580nM ΔG°: -35.2kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
Affinity DataKi: 590nMAssay Description:Displacement of FAM-Bid BH3 peptide from human recombinant Bcl2 by FP-based binding assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 638nMAssay Description:Displacement of FAM-Bak BH3 peptide from human Bcl-xL by FP-based binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 730nMAssay Description:Displacement of FAM-Bim peptide from human Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataKi: 857nM ΔG°: -34.3kJ/molepH: 8.5 T: 2°CAssay Description:The enzyme reaction was initiated by adding fluorescence peptide substrate to reaction mixture containing enzyme and test compounds. The enzyme activ...More data for this Ligand-Target Pair
Affinity DataKi: 860nM ΔG°: -34.3kJ/molepH: 8.5 T: 2°CAssay Description:The enzyme reaction was initiated by adding fluorescence peptide substrate to reaction mixture containing enzyme and test compounds. The enzyme activ...More data for this Ligand-Target Pair
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataKi: 890nM ΔG°: -34.2kJ/molepH: 8.5 T: 2°CAssay Description:The enzyme reaction was initiated by adding fluorescence peptide substrate to reaction mixture containing enzyme and test compounds. The enzyme activ...More data for this Ligand-Target Pair
Affinity DataKi: 930nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataKi: 1.00E+3nM ΔG°: -33.9kJ/molepH: 8.5 T: 2°CAssay Description:The enzyme reaction was initiated by adding fluorescence peptide substrate to reaction mixture containing enzyme and test compounds. The enzyme activ...More data for this Ligand-Target Pair