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Found 185 with Last Name = 'rossi' and Initial = 'ma'
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169690(CHEMBL3806137)
Affinity DataKi:  540nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM9048(US8536193, 10-5)
Affinity DataIC50:  0.340nMAssay Description:Activated Akt isoforms and pleckstrin homology domain deletion constructs were assayed utilizing a GSK-derived biotinylated peptide substrate. The e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM102310(US8536193, 10-4)
Affinity DataIC50:  0.380nMpH: 7.5Assay Description:Activated Akt isoforms and pleckstrin homology domain deletion constructs were assayed utilizing a GSK-derived biotinylated peptide substrate. The e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM8727(US8536193, 7-26)
Affinity DataIC50:  0.700nMAssay Description:Activated Akt isoforms and pleckstrin homology domain deletion constructs were assayed utilizing a GSK-derived biotinylated peptide substrate. The e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM102310(US8536193, 10-4)
Affinity DataIC50:  1.70nMpH: 7.5Assay Description:Activated Akt isoforms and pleckstrin homology domain deletion constructs were assayed utilizing a GSK-derived biotinylated peptide substrate. The e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM102311(US8536193, 2-1)
Affinity DataIC50:  2.30nMpH: 7.5Assay Description:Activated Akt isoforms and pleckstrin homology domain deletion constructs were assayed utilizing a GSK-derived biotinylated peptide substrate. The e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256715(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human cloned Akt1 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256714(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human cloned Akt1 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256723(9-phenyl-8-(4-((4-(4-(pyridin-2-yl)-1H-imidazol-1-...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human cloned Akt2 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256723(9-phenyl-8-(4-((4-(4-(pyridin-2-yl)-1H-imidazol-1-...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human cloned Akt1 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256718(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human cloned Akt1 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256719(3-methyl-9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human cloned Akt1 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256718(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Akt1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM102307(US8536193, 3-1)
Affinity DataIC50:  6.10nMpH: 7.5Assay Description:Activated Akt isoforms and pleckstrin homology domain deletion constructs were assayed utilizing a GSK-derived biotinylated peptide substrate. The e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256715(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human cloned Akt2 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM102308(US8536193, 4-1)
Affinity DataIC50:  8.20nMpH: 7.5Assay Description:Activated Akt isoforms and pleckstrin homology domain deletion constructs were assayed utilizing a GSK-derived biotinylated peptide substrate. The e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256717(1-(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-tr...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human cloned Akt1 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256714(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of human cloned Akt2 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256721(3-((4-methylpiperazin-1-yl)methyl)-9-phenyl-8-(4-(...)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of human cloned Akt1 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM102309(US8536193, 5-12)
Affinity DataIC50:  10nMpH: 7.5Assay Description:Activated Akt isoforms and pleckstrin homology domain deletion constructs were assayed utilizing a GSK-derived biotinylated peptide substrate. The e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256718(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human cloned Akt2 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256716(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human cloned Akt1 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256716(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  10.4nMAssay Description:Inhibition of human cloned Akt2 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256720(3-(chloromethyl)-9-phenyl-8-(4-((4-(5-(pyridin-2-y...)
Affinity DataIC50:  10.5nMAssay Description:Inhibition of human cloned Akt2 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Merck

Curated by ChEMBL
LigandPNGBDBM50242510(CHEMBL4095146)
Affinity DataIC50:  11nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7alpha incubated for 5 mins measured at 10 secs interval by PatchXpress automated electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50:  11nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells measured after 5 to 10 mins post compound washout by PatchXpress automated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256719(3-methyl-9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,...)
Affinity DataIC50:  14.6nMAssay Description:Inhibition of human cloned Akt2 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256716(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  17nMAssay Description:Inhibition of Akt1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256722(2-((9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-t...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human cloned Akt1 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256714(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  18.1nMAssay Description:Inhibition of Akt1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256723(9-phenyl-8-(4-((4-(4-(pyridin-2-yl)-1H-imidazol-1-...)
Affinity DataIC50:  18.3nMAssay Description:Inhibition of Akt1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50242509(CHEMBL4068937)
Affinity DataIC50:  21nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM102307(US8536193, 3-1)
Affinity DataIC50:  24nMpH: 7.5Assay Description:Activated Akt isoforms and pleckstrin homology domain deletion constructs were assayed utilizing a GSK-derived biotinylated peptide substrate. The e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256717(1-(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-tr...)
Affinity DataIC50:  24.1nMAssay Description:Inhibition of human cloned Akt2 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256719(3-methyl-9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,...)
Affinity DataIC50:  24.6nMAssay Description:Inhibition of Akt1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256720(3-(chloromethyl)-9-phenyl-8-(4-((4-(5-(pyridin-2-y...)
Affinity DataIC50:  26.7nMAssay Description:Inhibition of human cloned Akt1 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256715(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  27nMAssay Description:Inhibition of Akt1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50242509(CHEMBL4068937)
Affinity DataIC50:  29nMAssay Description:Inhibition of Nav1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Merck

Curated by ChEMBL
LigandPNGBDBM50242509(CHEMBL4068937)
Affinity DataIC50:  30nMAssay Description:Inhibition of [3H]PIA binding to rat cortical adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50242509(CHEMBL4068937)
Affinity DataIC50:  31nMAssay Description:Inhibition of NaV1.7 channel in human DRG neurons assessed as reduction of TTX-sensitive current by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM102311(US8536193, 2-1)
Affinity DataIC50:  32nMpH: 7.5Assay Description:Activated Akt isoforms and pleckstrin homology domain deletion constructs were assayed utilizing a GSK-derived biotinylated peptide substrate. The e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50242510(CHEMBL4095146)
Affinity DataIC50:  39nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM102312(US8536193, 1-9)
Affinity DataIC50:  39nMpH: 7.5Assay Description:Activated Akt isoforms and pleckstrin homology domain deletion constructs were assayed utilizing a GSK-derived biotinylated peptide substrate. The e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256718(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  41nMAssay Description:Inhibition of Akt2 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256722(2-((9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-t...)
Affinity DataIC50:  41.8nMAssay Description:Inhibition of Akt1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256714(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  47.7nMAssay Description:Inhibition of Akt2 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM102308(US8536193, 4-1)
Affinity DataIC50:  50nMpH: 7.5Assay Description:Activated Akt isoforms and pleckstrin homology domain deletion constructs were assayed utilizing a GSK-derived biotinylated peptide substrate. The e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256721(3-((4-methylpiperazin-1-yl)methyl)-9-phenyl-8-(4-(...)
Affinity DataIC50:  55.1nMAssay Description:Inhibition of human cloned Akt2 expressed in Drosophila S2 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50256721(3-((4-methylpiperazin-1-yl)methyl)-9-phenyl-8-(4-(...)
Affinity DataIC50:  62.5nMAssay Description:Inhibition of Akt1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50242508(CHEMBL4084948)
Affinity DataIC50:  74nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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