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Found 991 with Last Name = 'schmidt' and Initial = 'sj'
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  0.380nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  0.380nMAssay Description:Competitive inhibition of human Aurora B ATP binding site by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058526((S)-3-{[(1S,9S)-9-(4-Carboxymethoxy-benzoylamino)-...)
Affinity DataKi:  1nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058530((S)-3-{[(1S,9S)-9-(2-Fluoro-benzoylamino)-6,10-dio...)
Affinity DataKi:  1nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  1.5nMAssay Description:Competitive inhibition of human Aurora C ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  1.80nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
Target7-dehydrocholesterol reductase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50406621(CHEMBL9820)
Affinity DataKi:  4nMAssay Description:Compound was tested for the inhibition of Delta-(24)-sterol reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  4.60nMAssay Description:Competitive inhibition of Aurora C ATP binding siteMore data for this Ligand-Target Pair
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058528((S)-3-[((1S,9S)-9-Benzoylamino-6,10-dioxo-octahydr...)
Affinity DataKi:  5nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058527((S)-2-[(S)-2-((S)-2-Acetylamino-3-methyl-butyrylam...)
Affinity DataKi:  6nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target7-dehydrocholesterol reductase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50406617(CHEMBL276388)
Affinity DataKi:  7nMAssay Description:Compound was tested for the inhibition of Delta-(24)-sterol reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target7-dehydrocholesterol reductase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50406618(CHEMBL9875)
Affinity DataKi:  12nMAssay Description:Compound was tested for the inhibition of delta24-sterol reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50286304((R)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methy...)
Affinity DataKi:  15nMAssay Description:Binding affinity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50176519((S)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methy...)
Affinity DataKi:  15nMAssay Description:Binding affinity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058529((S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methy...)
Affinity DataKi:  15nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058531((S)-3-[((1S,9S)-9-Benzyloxycarbonylamino-6,10-diox...)
Affinity DataKi:  25nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target7-dehydrocholesterol reductase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50406620(CHEMBL9864)
Affinity DataKi:  33nMAssay Description:Compound was tested for the inhibition of delta24-sterol reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target7-dehydrocholesterol reductase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50406616(CHEMBL268041)
Affinity DataKi:  48nMAssay Description:Compound was tested for the inhibition of delta24-sterol reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  490nMAssay Description:Competitive inhibition of human Aurora A ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  492nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target7-dehydrocholesterol reductase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50406619(CHEMBL9808)
Affinity DataKi:  2.00E+3nMAssay Description:Compound was tested for the inhibition of Delta-(24)-sterol reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50572174(CHEMBL4878316)
Affinity DataKi:  7.67E+3nMAssay Description:Binding affinity to DENV2 NS2B-NS3 protease by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316497(CHEMBL1097106 | N-{4-[1-(2,3-Dihydroxypropyl)-4-(1...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50241089(2-(ethyl(3-(4-(5-(2-(3-fluorophenylamino)-2-oxoeth...)
Affinity DataIC50: <1nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316473(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316475(CHEMBL1097191 | N-Ethyl-N'-[4-(1-ethyl-4-{2-[4-(1-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316471(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091691(CHEMBL3582356)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316492(1-(4-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316498(CHEMBL1097454 | N-{4-[1-(3-Hydroxypropyl)-4-(1H-py...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316474(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091689(CHEMBL3582354)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132G](Homo sapiens (Human))
Albert Einstein College Of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  2.90nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316496(CHEMBL1099010 | N-{4-[1-(2-Hydroxyethyl)-4-(1H-pyr...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316470(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316472(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Albert Einstein College Of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  3.80nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
LigandPNGBDBM50091692(CHEMBL3582357)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091696(CHEMBL3582351)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091695(CHEMBL3582350)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316476(CHEMBL1097521 | N'-[4-(1-Ethyl-4-{2-[4-(1-pyrrolid...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Albert Einstein College Of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  4.60nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316478(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316479((4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-py...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316483(4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phen...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316481(4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phen...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316477(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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