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Found 846 with Last Name = 'schober' and Initial = 'o'
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50192784((S)-1-(4-(2-fluoroethoxy)benzyl)-5-(2-(phenoxymeth...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50304494(3-Benzo[1,3]dioxol-5-yl-4-[3-(2-bromoethoxy)-4,5-d...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50304495(2-{4-[4-(Benzo[1,3]dioxol-5-yl)-2-hydroxy-5-oxo-3-...)
Affinity DataKi:  0.360nMAssay Description:Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50200312((S)-1-(4-(2-(4-methylphenylsulfonyloxy)ethoxy)benz...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50304496(3-Benzo[1,3]dioxol-5-yl-4-[3-(2-fluoroethoxy)-4,5-...)
Affinity DataKi:  1.09nMAssay Description:Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50304496(3-Benzo[1,3]dioxol-5-yl-4-[3-(2-fluoroethoxy)-4,5-...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50200302((S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)-1...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50200305((S)-1-(4-iodobenzyl)-5-(2-phenoxymethyl-pyrrolidin...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50304497(2-(5-{[4-(Benzo[1,3]dioxol-5-yl)-2-hydroxy-2-(4-me...)
Affinity DataKi:  1.26nMAssay Description:Displacement of [125I]ET1 from endothelin B receptor in DBA mouse microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50304497(2-(5-{[4-(Benzo[1,3]dioxol-5-yl)-2-hydroxy-2-(4-me...)
Affinity DataKi:  1.26nMAssay Description:Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50336694(3-Benzo[1,3]dioxol-5-yl-4-{3-(2-(2-(2-(2-fluoroeth...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50200308((S)-1-(4-(tert-butyldimethylsilyloxy)benzyl)-5-[1-...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50336695(3-Benzo[1,3]dioxol-5-yl-4-{3-[1-(2-{2-[2-(2-fluoro...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50304498(3-Benzo[1,3]dioxol-5-yl-5-[4-(2-fluoroethoxy)pheny...)
Affinity DataKi:  2.43nMAssay Description:Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50336697(3-Benzo[1,3]dioxol-5-yl-4-[3-(2-{2-[2-(2-{4-[4-(2-...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50336699(CHEMBL1672884 | N-[1-(2-{2-[2-(2-{5-[4-Benzo[1,3]d...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM10334((S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrroli...)
Affinity DataKi:  4nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50336696(3-Benzo[1,3]dioxol-5-yl-4-[3-(2-{2-[2-(2-{1-[2-(2-...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM10330((S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrroli...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50200306((S)-1-(4-iodobenzyl)-5-[1-(2-methoxymethylpyrrolid...)
Affinity DataKi:  5.90nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50336698(CHEMBL1672885 | N-[1-(2-{2-[2-(2-{5-[4-Benzo[1,3]d...)
Affinity DataKi:  7.30nMAssay Description:Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50336700(3-Benzo[1,3]dioxol-5-yl-4-{3-[2-(2-{2-[2-(4-fluoro...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50200311((S)-1-(4-(2-bromoethoxy)benzyl)-5-[1-(2-methoxymet...)
Affinity DataKi:  8nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  8nMAssay Description:Inhibition of human active MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM10318((S)-5-{1-[2-(Phenoxymethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  8.30nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50200310((S)-1-(4-(2-(4-methylphenylsulfonyloxy)ethoxy)benz...)
Affinity DataKi:  8.60nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50200303((S)-1-(4-methoxybenzyl)-5-[1-(2-methoxymethylpyrro...)
Affinity DataKi:  9nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50200314((S)-1-(4-(tert-butyldimethylsilyloxy)benzyl)-5-[1-...)
Affinity DataKi:  9.80nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM13126((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  11nMAssay Description:Inhibition of human active MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM13126((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  11nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM13126((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  11nMAssay Description:Inhibition of MMP2 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50200313((S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-...)
Affinity DataKi:  12.6nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50200315((S)-1-(4-(2-bromoethoxy)benzyl)-5-[1-(2-phenoxymet...)
Affinity DataKi:  12.6nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM10320((S)-1-Methyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant caspase 3 using Ac-DEVD-AMC substrate assessed as accumulation of cleaved fluorogenic productMore data for this Ligand-Target Pair
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50200309((S)-1-(4-(2-fluoroethoxy)benzyl)-5-[1-(2-methoxyme...)
Affinity DataKi:  17.9nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  20nMAssay Description:Inhibition of human active MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM13126((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  23nMAssay Description:Inhibition of MMP8 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM13126((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  23nMAssay Description:Inhibition of MMP-8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50200307((S)-1-(4-hydroxybenzyl)-5-[1-(2-methoxymethylpyrro...)
Affinity DataKi:  23.5nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50304499(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-[4-(2-bromoeth...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM13126((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  27nMAssay Description:Inhibition of human active MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM13126((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  27nMAssay Description:Inhibition of MMP9 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM13126((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  27nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50336697(3-Benzo[1,3]dioxol-5-yl-4-[3-(2-{2-[2-(2-{4-[4-(2-...)
Affinity DataKi:  37nMAssay Description:Displacement of [125I]ET1 from ETB receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Affinity DataKi:  41.8nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM10320((S)-1-Methyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)
Affinity DataKi:  47nMAssay Description:Inhibition of human recombinant caspase 7 using Ac-DEVD-AMC substrate assessed as accumulation of cleaved fluorogenic productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM10320((S)-1-Methyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)
Affinity DataKi:  56.1nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
TargetCaspase-3(Homo sapiens (Human))
University Hospital Of The WestfäLische Wilhelms-UniversitäT

Curated by ChEMBL
LigandPNGBDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Affinity DataKi:  60nMAssay Description:Inhibition of human recombinant caspase 3 using Ac-DEVD-AMC substrate assessed as accumulation of cleaved fluorogenic productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50304499(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-[4-(2-bromoeth...)
Affinity DataKi:  72nMAssay Description:Displacement of [125I]ET1 from endothelin B receptor in DBA mouse microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Mus musculus)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50304495(2-{4-[4-(Benzo[1,3]dioxol-5-yl)-2-hydroxy-5-oxo-3-...)
Affinity DataKi:  96nMAssay Description:Displacement of [125I]ET1 from endothelin B receptor in DBA mouse microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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