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Polyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Seoul National University

Curated by ChEMBL

BDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)

Ki: 5.83E+5nMAssay Description:Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPAMore data for this Ligand-Target Pair

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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391953(CHEMBL2152288)

IC50: 1.67nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391978(CHEMBL2152287)

IC50: 2.97nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391977(CHEMBL2152286)

IC50: 4.62nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391950(CHEMBL2152289)

IC50: 5.41nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Voltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
The Catholic University Of Korea

Curated by ChEMBL

BDBM50262085(CHEMBL468397 | methyl 5-((3-(1H-benzo[d]imidazol-2...)

IC50: 8.20nMAssay Description:Inhibition of T-type calcium channel subunit alpha-1G (unknown origin) expressed in HEK293 cells assessed as inactivation of channel current at holdi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391974(CHEMBL2152283)

IC50: 8.36nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391976(CHEMBL2152285)

IC50: 9.40nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391973(CHEMBL2152282)

IC50: 13.6nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391971(CHEMBL2152280)

IC50: 18.6nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391968(CHEMBL2152277)

IC50: 22.2nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391963(CHEMBL2152272)

IC50: 22.7nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391965(CHEMBL2152274)

IC50: 25.0nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391962(CHEMBL2152271)

IC50: 26.5nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391961(CHEMBL2152270)

IC50: 31.4nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391966(CHEMBL2152275)

IC50: 33.2nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391975(CHEMBL2152284)

IC50: 33.8nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391964(CHEMBL2152273)

IC50: 34.3nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Voltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
The Catholic University Of Korea

Curated by ChEMBL

BDBM50222222(CHEMBL394956 | KYS-05090 | N-benzyl-2-(3-(biphenyl...)

IC50: 41nMAssay Description:Inhibition of T-type calcium channel alpha 1 GMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391955(CHEMBL2152264)

IC50: 42.7nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391970(CHEMBL2152279)

IC50: 47nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391967(CHEMBL2152276)

IC50: 53.7nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Voltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
The Catholic University Of Korea

Curated by ChEMBL

BDBM50495798(CHEMBL3115194)

IC50: 56nMAssay Description:Inhibition of T-type calcium channel subunit alpha-1G (unknown origin) expressed in HEK293 cells assessed as inactivation of channel current at holdi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391972(CHEMBL2152281)

IC50: 64.7nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391960(CHEMBL2152269)

IC50: 69.6nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB KEGG
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Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Catholic University Of Korea

Curated by ChEMBL

BDBM50123843(CHEMBL3623427)

IC50: 80nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as reduction in inhibition of reduction of trans-2-octenoyl N-acetylcysteamine substrate by spectro...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391969(CHEMBL2152278)

IC50: 88.6nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Voltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
The Catholic University Of Korea

Curated by ChEMBL

BDBM50262239(CHEMBL513338 | methyl 2-(4-bromophenyl)-2-isopropy...)

IC50: 95nMAssay Description:Inhibition of T-type calcium channel subunit alpha-1G (unknown origin) expressed in HEK293 cells assessed as inactivation of channel current at holdi...More data for this Ligand-Target Pair

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Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL

BDBM50459685(CHEMBL4209785)

IC50: 100nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair

PDB MMDB KEGG
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Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Catholic University Of Korea

Curated by ChEMBL

BDBM50123848(CHEMBL3623422)

IC50: 110nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as reduction in inhibition of reduction of trans-2-octenoyl N-acetylcysteamine substrate by spectro...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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High affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391951(CHEMBL2152290)

IC50: 110nMAssay Description:Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrateMore data for this Ligand-Target Pair

PDB MMDB KEGG
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Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Catholic University Of Korea

Curated by ChEMBL

BDBM50123853(CHEMBL3623417)

IC50: 120nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as reduction in inhibition of reduction of trans-2-octenoyl N-acetylcysteamine substrate by spectro...More data for this Ligand-Target Pair

PDB Reactome pathway
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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL

BDBM50391953(CHEMBL2152288)

IC50: 145nMAssay Description:Inhibition of KIT by high throughput binding assayMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Inhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Korea University

Curated by ChEMBL

BDBM50390272(CHEMBL2070415)

IC50: 160nMAssay Description:Inhibition of IKKbeta using 5FAM-GRHDSGLDSMK-NH2 as substrate incubated for 10 mins prior to substrate addition by IMAP-TR-FRET assayMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Inhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Korea University

Curated by ChEMBL

BDBM50149806(2''-Amino-6''-(2-hydroxy-phenyl)-1,2,3,4,5,6-hexah...)

IC50: 170nMAssay Description:Inhibition of IKKbeta using 5FAM-GRHDSGLDSMK-NH2 as substrate incubated for 10 mins prior to substrate addition by IMAP-TR-FRET assayMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Catholic University Of Korea

Curated by ChEMBL

BDBM50262085(CHEMBL468397 | methyl 5-((3-(1H-benzo[d]imidazol-2...)

IC50: 178nMAssay Description:Inhibition of human ERG by whole-cell patch clamp methodMore data for this Ligand-Target Pair

PDB MMDB KEGG
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Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Catholic University Of Korea

Curated by ChEMBL

BDBM50123838(CHEMBL3623432)

IC50: 220nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as reduction in inhibition of reduction of trans-2-octenoyl N-acetylcysteamine substrate by spectro...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Inhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Korea University

Curated by ChEMBL

BDBM50390261(CHEMBL2070414)

IC50: 230nMAssay Description:Inhibition of IKKbeta using 5FAM-GRHDSGLDSMK-NH2 as substrate incubated for 10 mins prior to substrate addition by IMAP-TR-FRET assayMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Inhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Korea University

Curated by ChEMBL

BDBM50390260(CHEMBL2070413)

IC50: 350nMAssay Description:Inhibition of IKKbeta (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Inhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Korea University

Curated by ChEMBL

BDBM50390260(CHEMBL2070413)

IC50: 350nMAssay Description:Inhibition of IKKbeta using 5FAM-GRHDSGLDSMK-NH2 as substrate incubated for 10 mins prior to substrate addition by IMAP-TR-FRET assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL

BDBM50459697(CHEMBL4214693)

IC50: 360nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair

PDB MMDB KEGG
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Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Catholic University Of Korea

Curated by ChEMBL

BDBM50123827(CHEMBL3623392)

IC50: 380nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as reduction in inhibition of reduction of trans-2-octenoyl N-acetylcysteamine substrate by spectro...More data for this Ligand-Target Pair

PDB MMDB KEGG
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Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Catholic University Of Korea

Curated by ChEMBL

BDBM50123849(CHEMBL3623421)

IC50: 400nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as reduction in inhibition of reduction of trans-2-octenoyl N-acetylcysteamine substrate by spectro...More data for this Ligand-Target Pair

PDB MMDB KEGG
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Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Catholic University Of Korea

Curated by ChEMBL

BDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)

IC50: 440nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as reduction in inhibition of reduction of trans-2-octenoyl N-acetylcysteamine substrate by spectro...More data for this Ligand-Target Pair

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3D Structure (crystal)

Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Catholic University Of Korea

Curated by ChEMBL

BDBM50123828(CHEMBL3623391)

IC50: 450nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as reduction in inhibition of reduction of trans-2-octenoyl N-acetylcysteamine substrate by spectro...More data for this Ligand-Target Pair

PDB MMDB KEGG
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PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Catholic University Of Korea

Curated by ChEMBL

BDBM50123847(CHEMBL3623423)

IC50: 470nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as reduction in inhibition of reduction of trans-2-octenoyl N-acetylcysteamine substrate by spectro...More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Catholic University Of Korea

Curated by ChEMBL

BDBM50123852(CHEMBL3623418)

IC50: 480nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as reduction in inhibition of reduction of trans-2-octenoyl N-acetylcysteamine substrate by spectro...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Inhibitor of nuclear factor kappa-B kinase subunit beta(Mus musculus)
The Catholic University Of Korea

Curated by ChEMBL

BDBM50146936(CHEMBL3765499)

IC50: 500nMAssay Description:Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by E...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL

BDBM50459699(CHEMBL4215206)

IC50: 600nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair