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Found 275 with Last Name = 'shepard' and Initial = 'rm'
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352059(CHEMBL1824026)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144428(CHEMBL66159 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352039(CHEMBL1823817)
Affinity DataIC50:  1.30nMAssay Description:Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352059(CHEMBL1824026)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144400(CHEMBL304358 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352060(CHEMBL1824027)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352058(CHEMBL560241)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352059(CHEMBL1824026)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at P2X7R expressed in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL-1beta releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144420(CHEMBL68145 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352052(CHEMBL1824020)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144431(CHEMBL303673 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  7nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352060(CHEMBL1824027)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352058(CHEMBL560241)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144428(CHEMBL66159 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  7nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209006(1-(2-(2-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpi...)
Affinity DataIC50:  8nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144431(CHEMBL303673 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144420(CHEMBL68145 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144417(CHEMBL68366 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  9nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352060(CHEMBL1824027)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at P2X7R expressed in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL-1beta releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352055(CHEMBL549618)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144417(CHEMBL68366 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209001(4-(2-(2-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpi...)
Affinity DataIC50:  13nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144421(CHEMBL302533 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209003((2-(2-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpipe...)
Affinity DataIC50:  23nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144419(CHEMBL305423 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  27nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144400(CHEMBL304358 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  28nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352061(CHEMBL1824022)
Affinity DataIC50:  28nMAssay Description:Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209000(2-(2-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiper...)
Affinity DataIC50:  30nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144419(CHEMBL305423 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  31nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318005(2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(5-met...)
Affinity DataIC50:  31nMAssay Description:Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50208999((R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  31nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209004(2-(2-(2-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpi...)
Affinity DataIC50:  38nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209002(CHEMBL391239 | methyl 2-(2-(2-((2R,5S)-4-(4-fluoro...)
Affinity DataIC50:  44nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144422(CHEMBL308473 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  46nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144425(CHEMBL304053 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  52nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50208998(2-(2-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiper...)
Affinity DataIC50:  59nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144422(CHEMBL308473 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  65nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144423(CHEMBL302320 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  68nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144416(CHEMBL69123 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  75nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318005(2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(5-met...)
Affinity DataIC50:  95nMAssay Description:Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352040(CHEMBL1823818)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144424(CHEMBL306457 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  120nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352058(CHEMBL560241)
Affinity DataIC50:  121nMAssay Description:Antagonist activity at P2X7R expressed in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL-1beta releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144416(CHEMBL69123 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  130nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352054(CHEMBL1824023)
Affinity DataIC50:  180nMAssay Description:Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352055(CHEMBL549618)
Affinity DataIC50:  180nMAssay Description:Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144421(CHEMBL302533 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  220nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352056(CHEMBL1824024)
Affinity DataIC50:  238nMAssay Description:Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352053(CHEMBL1824021)
Affinity DataIC50:  240nMAssay Description:Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50352048(CHEMBL1824016)
Affinity DataIC50:  250nMAssay Description:Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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