Found 105 with Last Name = 'sidransky' and Initial = 'e' TargetSomatostatin receptor type 4(Homo sapiens (Human))
National Human Genome Research Institute
Curated by ChEMBL
National Human Genome Research Institute
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:Binding affinity to human SST4 receptorMore data for this Ligand-Target Pair
TargetSomatostatin receptor type 4(Homo sapiens (Human))
National Human Genome Research Institute
Curated by ChEMBL
National Human Genome Research Institute
Curated by ChEMBL
Affinity DataKi: 19nMAssay Description:Binding affinity to human SST4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 21nM ΔG°: -43.2kJ/mole IC50: 31nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
TargetSomatostatin receptor type 4(Homo sapiens (Human))
National Human Genome Research Institute
Curated by ChEMBL
National Human Genome Research Institute
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Binding affinity to human SST4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 52nM ΔG°: -41.0kJ/mole IC50: 103nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 55nM ΔG°: -40.9kJ/mole IC50: 133nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 56nM ΔG°: -40.8kJ/mole IC50: 63nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 102nM ΔG°: -39.4kJ/mole IC50: 168nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 120nM ΔG°: -39.0kJ/mole IC50: 268nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 121nM ΔG°: -39.0kJ/mole IC50: 183nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
TargetSomatostatin receptor type 4(Homo sapiens (Human))
National Human Genome Research Institute
Curated by ChEMBL
National Human Genome Research Institute
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Binding affinity to human SST4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 184nM ΔG°: -37.9kJ/mole IC50: 452nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 320nM ΔG°: -36.6kJ/mole IC50: 430nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 514nM ΔG°: -35.4kJ/mole IC50: 1.06E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 556nM ΔG°: -35.2kJ/mole IC50: 1.29E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
TargetSomatostatin receptor type 4(Homo sapiens (Human))
National Human Genome Research Institute
Curated by ChEMBL
National Human Genome Research Institute
Curated by ChEMBL
Affinity DataKi: 690nMAssay Description:Binding affinity to human SST4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 975nM ΔG°: -33.8kJ/mole IC50: 2.45E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 2.78E+3nM ΔG°: -31.3kJ/mole IC50: 4.31E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 4.23E+3nM ΔG°: -30.3kJ/mole IC50: 7.73E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 7.15E+3nM ΔG°: -29.0kJ/mole IC50: 2.46E+4nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 8.44E+3nM ΔG°: -28.6kJ/mole IC50: 2.96E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 1.34E+4nM ΔG°: -27.4kJ/mole IC50: 6.46E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 1.92E+4nM ΔG°: -26.6kJ/mole IC50: 2.52E+4nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 2.34E+4nM ΔG°: -26.1kJ/mole IC50: 3.44E+4nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 5.06E+4nM ΔG°: -24.2kJ/mole IC50: >1.00E+5nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataKi: 1.22E+5nM ΔG°: -22.0kJ/molepH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 30nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs...More data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataIC50: 710nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 730nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 770nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 940nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 960nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+3nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Affinity DataIC50: 1.08E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.53E+3nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 1.88E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
