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Found 92 with Last Name = 'silva' and Initial = 'am'
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50445691(CHEMBL243677)
Affinity DataKi:  1.80E+4nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7461(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...)
Affinity DataKi:  1.94E+4nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50157555(2-(3,4-dihydroxyphenyl)-4H-chromen-4-one | 3',4'-d...)
Affinity DataKi:  8.45E+4nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50445690(CHEMBL457821)
Affinity DataKi:  9.54E+4nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50312650(5,4'-dihydroxyflavone | 5-hydroxy-2-(4-hydroxyphen...)
Affinity DataKi:  1.03E+5nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataKi:  1.07E+5nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataKi:  1.22E+5nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7458(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataKi:  1.78E+5nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50276368(CHEMBL4128371)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50:  107nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50163745(4,40-(1E,10E)-2,20-(Isoxazole-3,5-diyl)bis(ethene-...)
Affinity DataIC50:  138nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50163748((E)-3,5-Bis[beta-(4-Hydroxy-3-methoxyphenyl)-ethen...)
Affinity DataIC50:  476nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
University Of Porto-Rua Anibal Cunha

LigandPNGBDBM85585(2-Styrylchromone derivate, 3c)
Affinity DataIC50:  550nMpH: 7.8 T: 2°CAssay Description:The effect of 2-styrylchromone 1-3 on xanthine oxidase activity was evaluated by measuring the formation of uric acid from xanthine in a double beam ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50:  900nMAssay Description:Inhibition of amyloid beta (unknown origin) incubated for 7 days by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of amyloid beta 40 (unknown origin) assessed as disaggregation of fibrillar amyloid beta 40 incubated for 3 days by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601422(CHEMBL5174150)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601423(CHEMBL5195740)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601424(CHEMBL5209194)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601425(CHEMBL5189854)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601426(CHEMBL5200280)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601428(CHEMBL5175279)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601427(CHEMBL5176644)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMicrotubule-associated protein tau(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601425(CHEMBL5189854)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50157555(2-(3,4-dihydroxyphenyl)-4H-chromen-4-one | 3',4'-d...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50077325(2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one |...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
University Of Porto-Rua Anibal Cunha

LigandPNGBDBM85584(2-Styrylchromone derivate, 3b)
Affinity DataIC50:  2.03E+3nMpH: 7.8 T: 2°CAssay Description:The effect of 2-styrylchromone 1-3 on xanthine oxidase activity was evaluated by measuring the formation of uric acid from xanthine in a double beam ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
University Of Porto-Rua Anibal Cunha

LigandPNGBDBM85579(2-Styrylchromone derivate, 1d)
Affinity DataIC50:  2.52E+3nMpH: 7.8 T: 2°CAssay Description:The effect of 2-styrylchromone 1-3 on xanthine oxidase activity was evaluated by measuring the formation of uric acid from xanthine in a double beam ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human liver FBP1 incubated for 5 mins by fluorescence methodMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50445691(CHEMBL243677)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601425(CHEMBL5189854)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601431(CHEMBL5183237)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
University Of Porto-Rua Anibal Cunha

LigandPNGBDBM85583(2-Styrylchromone derivate, 3a)
Affinity DataIC50:  4.36E+3nMpH: 7.8 T: 2°CAssay Description:The effect of 2-styrylchromone 1-3 on xanthine oxidase activity was evaluated by measuring the formation of uric acid from xanthine in a double beam ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601428(CHEMBL5175279)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601426(CHEMBL5200280)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMicrotubule-associated protein tau(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50553256(CHEMBL258632 | N-(3-Nitrophenylpyrazole)Curcumin)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601427(CHEMBL5176644)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601426(CHEMBL5200280)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
University Of Porto-Rua Anibal Cunha

LigandPNGBDBM35440(ALLOPURINOL | MLS000069453 | SMR000059083 | cid_20...)
Affinity DataIC50:  5.43E+3nMpH: 7.8 T: 2°CAssay Description:The effect of 2-styrylchromone 1-3 on xanthine oxidase activity was evaluated by measuring the formation of uric acid from xanthine in a double beam ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601425(CHEMBL5189854)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601431(CHEMBL5183237)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50163745(4,40-(1E,10E)-2,20-(Isoxazole-3,5-diyl)bis(ethene-...)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601428(CHEMBL5175279)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50163745(4,40-(1E,10E)-2,20-(Isoxazole-3,5-diyl)bis(ethene-...)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50304350(CHEMBL611029 | Herbacetin)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of human liver FBP1 incubated for 5 mins by fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50163748((E)-3,5-Bis[beta-(4-Hydroxy-3-methoxyphenyl)-ethen...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601427(CHEMBL5176644)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601429(CHEMBL492807)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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