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Found 292 with Last Name = 'spanka' and Initial = 'c'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305056((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305056((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]ABP688 from human recombinant mGluR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of FGFR3 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of recombinant FGFR1More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant FGFR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of recombinant FGFR2More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  2nMAssay Description:Inhibition of FGFR2 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  2nMAssay Description:Inhibition of FGFR3-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of FGFR1-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of wild type FGFR1 expressed in HEK293 cells assessed as inhibition of autophosphorylation of tyrosine residue after 40 mins by ELISA assa...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of wild type FGFR2 expressed in HEK293 cells assessed as inhibition of autophosphorylation of tyrosine residue after 40 mins by ELISA assa...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305054(CHEMBL594767 | rac-(2-butylpiperidin-1-yl)(5-chlor...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of quisqualate-induced intracellular inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305053(CHEMBL595703 | rac-(5-chloro-6-(6-methylpyridin-3-...)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of quisqualate-induced intracellular inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651803(6-chloro-2-(5-(1,1-difluoro-2- methoxyethyl)-4H-1,...)
Affinity DataIC50:  30nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651804(5-(6-chloro-5-methoxy-3-(1H- pyrazol-4-yl)-1H-pyrr...)
Affinity DataIC50:  30nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651791(6-chloro-2-(5-(1,1-difluoro- ethyl)-4H-1,2,4-triaz...)
Affinity DataIC50:  32nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305056((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of glutamate-induced elevation of intracellular calcium concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305056((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataIC50:  36nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of quisqualate-induced intracellular inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305048((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of glutamate-induced elevation of intracellular calcium concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305049((S)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of glutamate-induced elevation of intracellular calcium concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651815(2-(5-(6-chloro-3-(1H-imidazol- 1-yl)-5-methoxy-1-m...)
Affinity DataIC50:  45nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305046(CHEMBL611050 | rac-(5-chloro-6-(6-methylpyridin-3-...)
Affinity DataIC50:  48nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of quisqualate-induced intracellular inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651822(2-(5-(6-chloro-3-(1H-imidazol- 1-yl)-5-methoxy-1-m...)
Affinity DataIC50:  54nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651796(6-chloro-2-(5-(1,1-difluoro-2- methoxyethyl)-4H-1,...)
Affinity DataIC50:  55nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  60nMAssay Description:Inhibition of recombinant FGFR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651816(1-(5-(6-chloro-3-(1H-imidazol- 1-yl)-5-methoxy-1-m...)
Affinity DataIC50:  61nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651798(6-chloro-2-(5-fluoro-4H- 1,2,4-triazol-3-yl)-5-met...)
Affinity DataIC50:  63nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305046(CHEMBL611050 | rac-(5-chloro-6-(6-methylpyridin-3-...)
Affinity DataIC50:  65nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of glutamate-induced elevation of intracellular calcium concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651794(1-(5-(6-chloro-5-methoxy-3- (1H-pyrazol-4-yl)-1H- ...)
Affinity DataIC50:  66nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651830(1-(5-(6-chloro-5-methoxy-1- methyl-3-(1H-pyrazol-4...)
Affinity DataIC50:  66nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651829(6-chloro-5-methoxy-1-methyl- 3-(1H-pyrazol-4-yl)-2...)
Affinity DataIC50:  67nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305048((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataIC50:  69nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of quisqualate-induced intracellular inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651789(6-chloro-5-methoxy-1-methyl- 3-(1H-pyrazol-4-yl)-2...)
Affinity DataIC50:  76nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651832(6-chloro-2-(5-(1,2-dimethoxy- ethyl)-4H-1,2,4-tria...)
Affinity DataIC50:  77nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651819(6-chloro-2-(5-(1,1-difluoro- ethyl)-4H-1,2,4-triaz...)
Affinity DataIC50:  79nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651834(6-chloro-3-(1H-imidazol-1-yl)- 5-methoxy-2-(5-(tri...)
Affinity DataIC50:  80nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305044((5-chloro-6-(6-methylpyridin-3-ylamino)pyridin-3-y...)
Affinity DataIC50:  87nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of glutamate-induced elevation of intracellular calcium concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305052(CHEMBL594297 | rac-(5-chloro-6-(6-methylpyridin-3-...)
Affinity DataIC50:  90nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of quisqualate-induced intracellular inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305053(CHEMBL595703 | rac-(5-chloro-6-(6-methylpyridin-3-...)
Affinity DataIC50:  90nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of glutamate-induced elevation of intracellular calcium concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651835(6-chloro-5-methoxy-3-(1H- pyrazol-4-yl)-2-(5-(trif...)
Affinity DataIC50:  91nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651810(6-chloro-2-(5-(2,2-difluoro-1- methoxyethyl)-4H-1,...)
Affinity DataIC50:  93nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305038((5-chloro-6-(4-chlorophenylamino)pyridin-3-yl)(3-m...)
Affinity DataIC50:  95nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of glutamate-induced elevation of intracellular calcium concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651793(2-(5-(6-chloro-5-methoxy-3- (1H-pyrazol-4-yl)-1H- ...)
Affinity DataIC50:  97nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651831(5-(6-chloro-5-methoxy-1-meth- yl-3-(1H-pyrazol-4-y...)
Affinity DataIC50:  98nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355394(CHEMBL1834663)
Affinity DataIC50: <100nMAssay Description:Inhibition of CYP3A4 using DBF as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651828((E)-1-(5-(6-chloro-3-(1H- imidazol-1-yl)-5-methoxy...)
Affinity DataIC50:  101nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305045(CHEMBL594295 | rac-(5-chloro-6-(6-methylpyridin-3-...)
Affinity DataIC50:  105nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of glutamate-induced elevation of intracellular calcium concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase [147-522](Homo sapiens (Human))TBA
LigandPNGBDBM651814(6-chloro-3-(1H-imidazol-1-yl)- 5-methoxy-1-methyl-...)
Affinity DataIC50:  107nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305049((S)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of quisqualate-induced intracellular inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305052(CHEMBL594297 | rac-(5-chloro-6-(6-methylpyridin-3-...)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of glutamate-induced elevation of intracellular calcium concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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