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Found 47 with Last Name = 'staker' and Initial = 'bl'
TargetDihydrofolate reductase(Homo sapiens (Human))
Universidade Estadual De Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50548088(CHEMBL3040038)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Cgi Pharmaceuticals

LigandPNGBDBM36516(4-(tert-Butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morp...)
Affinity DataIC50:  1.90nM Kd:  1.5nMpH: 7.5 T: 2°CAssay Description:Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.More data for this Ligand-Target Pair
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Decode Chemistry

LigandPNGBDBM50232538(5-((1-(2-fluorobenzyl)piperidin-4-yl)methoxy)quina...)
Affinity DataIC50:  7.62nM EC50:  4nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Decode Chemistry

LigandPNGBDBM36533(D157555)
Affinity DataIC50:  9.38nM EC50:  108nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Decode Chemistry

LigandPNGBDBM36531(D158963)
Affinity DataIC50:  23.4nM EC50:  223nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50073854(2,10-dihydroxy-12-(3,4,5-trihydroxy-6-hydroxymethy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of topoisomerase I-DNA complex in trapping assayMore data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321626(CHEMBL1171504 | N-(2-chloro-5-(1-(3-(4-(6-chloro-3...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Decode Chemistry

LigandPNGBDBM36530(D157493)
Affinity DataIC50:  43.9nM EC50:  67nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  50nMAssay Description:Inhibition of topoisomerase I-DNA complex in trapping assayMore data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM76305(5-chloranylquinolin-8-ol | 5-chloro-8-quinolinol |...)
Affinity DataIC50:  55nMAssay Description:Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ...More data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321625(CHEMBL1171503 | CatS_4 | N-(2-chloro-5-(2-(3-(4-(6...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Decode Chemistry

LigandPNGBDBM36532(D158885)
Affinity DataIC50:  101nM EC50:  795nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321627(CHEMBL1171505 | CatS_6 | N-(2-chloro-5-(4-(3-(4-(6...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50008923((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...)
Affinity DataIC50:  300nMAssay Description:Inhibition of topoisomerase I-DNA complex in trapping assayMore data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321624(CHEMBL1171502 | N-(2-chloro-5-(1-(3-(4-(6-chloro-3...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Decode Chemistry

LigandPNGBDBM36529(D156676)
Affinity DataIC50:  339nM EC50:  2.54E+3nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321623(CHEMBL1171314 | N-(2-chloro-5-(1-(3-(4-(6-chloro-3...)
Affinity DataIC50:  430nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Cgi Pharmaceuticals

LigandPNGBDBM36521(6-(tert-Butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morp...)
Affinity DataIC50:  650nMpH: 7.5 T: 2°CAssay Description:Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM32203(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)
Affinity DataIC50:  1.27E+3nMAssay Description:Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321622(CHEMBL1170609 | N-(2-chloro-5-(6-oxo-1-(3-(4-(2-ox...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321620(CHEMBL1171313 | N-(2-chloro-5-(6-oxo-1-(3-(4-(3-(t...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321625(CHEMBL1171503 | CatS_4 | N-(2-chloro-5-(2-(3-(4-(6...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of cathepsin S-mediated invariant chain degradation in human JY B-cells assessed as accumulation of p10 fragment by Western blot analysisMore data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50065785(2-Methyl-quinolin-8-ol | CHEMBL316892)
Affinity DataIC50:  2.03E+3nMAssay Description:Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321621(CHEMBL1171608 | N-(2-chloro-5-(6-oxo-1-(3-(4-(2-ox...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Cgi Pharmaceuticals

LigandPNGBDBM36518(CID46942382 | N-(2-Methyl-3-(4-methyl-6-((4-(morph...)
Affinity DataIC50:  2.69E+3nMpH: 7.5 T: 2°CAssay Description:Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Cgi Pharmaceuticals

LigandPNGBDBM36520(3-(tert-Butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morp...)
Affinity DataIC50:  3.14E+3nMpH: 7.5 T: 2°CAssay Description:Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50164286(4-(5,11-Dioxo-5,6a,11,11a-tetrahydro-indeno[1,2-c]...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of topoisomerase I-DNA complex in trapping assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Cgi Pharmaceuticals

LigandPNGBDBM36517(5-(3-Amino-2-methylphenyl)-1-methyl-3-((4-(morphol...)
Affinity DataIC50:  5.44E+3nMpH: 7.5 T: 2°CAssay Description:Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321626(CHEMBL1171504 | N-(2-chloro-5-(1-(3-(4-(6-chloro-3...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of cathepsin S-mediated invariant chain degradation in human JY B-cells assessed as accumulation of p10 fragment by Western blot analysisMore data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321627(CHEMBL1171505 | CatS_6 | N-(2-chloro-5-(4-(3-(4-(6...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of cathepsin S-mediated invariant chain degradation in human JY B-cells assessed as accumulation of p10 fragment by Western blot analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Cgi Pharmaceuticals

LigandPNGBDBM36519(5-(3-((4-(tert-Butyl)benzyl)amino)-2-methylphenyl)...)
Affinity DataIC50:  9.06E+3nMpH: 7.5 T: 2°CAssay Description:Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM32203(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)
Affinity DataIC50:  1.29E+4nMAssay Description:Inhibition of recombinant full length human His-tagged methionine aminopeptidase 1 expressed in Escherichia coli BL21(DE3) using methionylprolyl-p-ni...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321619(CHEMBL1171421 | N-(2-chloro-5-(6-oxo-1-(3-(pyrroli...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50065785(2-Methyl-quinolin-8-ol | CHEMBL316892)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of recombinant full length human His-tagged methionine aminopeptidase 1 expressed in Escherichia coli BL21(DE3) using methionylprolyl-p-ni...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50211290(CHEMBL2407096)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of recombinant full length human His-tagged methionine aminopeptidase 1 expressed in Escherichia coli BL21(DE3) using methionylprolyl-p-ni...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50211290(CHEMBL2407096)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM76305(5-chloranylquinolin-8-ol | 5-chloro-8-quinolinol |...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of recombinant full length human His-tagged methionine aminopeptidase 1 expressed in Escherichia coli BL21(DE3) using methionylprolyl-p-ni...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443775(CHEMBL3094105)
Affinity DataKd:  2.00E+5nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Decode Chemistry

LigandPNGBDBM36534(D156095)
Affinity DataEC50:  104nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443771(CHEMBL3094103)
Affinity DataKd:  1.48E+5nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443770(CHEMBL3094104)
Affinity DataKd:  7.00E+4nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443772(CHEMBL1230597)
Affinity DataKd:  1.80E+5nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Decode Chemistry

LigandPNGBDBM36535(D157554)
Affinity DataEC50:  921nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443774(CHEMBL3094106)
Affinity DataKd:  9.00E+4nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443773(CHEMBL1230528)
Affinity DataKd:  1.35E+5nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50194153(5'-CDP | CDP | CHEMBL425252 | Cytidine | Cytidine ...)
Affinity DataKd:  7.50E+4nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Decode Chemistry

LigandPNGBDBM36536(D153215)
Affinity DataEC50:  243nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed