Affinity DataKi: 0.0290nMAssay Description:Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]-5-HTMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataKi: 0.390nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.420nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.760nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.870nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [3H]-NAMH from human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]-5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]-5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Binding affinity was measured on cloned Human 5-hydroxytryptamine 1A receptor which is labeled by [3H]-8-OH-DPATMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.84nMAssay Description:Binding affinity was measured on cloned human 5-hydroxytryptamine 1A receptor which is labeled by [3H]-8-OH-DPATMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [3H]-NAMH from human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [3H]-NAMH from human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [3H]-NAMH from rat histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.05nMAssay Description:Displacement of [3H]-5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3.36nMAssay Description:Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]-5-HTMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.30nMAssay Description:Displacement of [3H]-5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 4.30nM ΔG°: -47.3kJ/mole EC50: 14nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
Affinity DataKi: 4.40nMAssay Description:Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.40nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.60nMAssay Description:Displacement of [3H]NAMH from rat cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 5.05nMAssay Description:Binding affinity was measured on cloned Human 5-hydroxytryptamine 1A receptor which is labeled by [3H]-8-OH-DPATMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 5.10nM ΔG°: -46.9kJ/mole EC50: 8.64nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
Affinity DataKi: 5.40nMAssay Description:Displacement of [3H]NAMH from human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 5.60nMAssay Description:Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]-5-HTMore data for this Ligand-Target Pair
Affinity DataKi: 5.60nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 5.70nMAssay Description:Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 5.80nMAssay Description:Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Displacement of [3H]-NAMH from rat histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Displacement of [3H]-NAMH from rat histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:Displacement of [3H]NAMH from rat cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair