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Found 122 with Last Name = 'tomassi' and Initial = 'c'
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50485231(CHEMBL2041942)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Human immunodeficiency virus 1 3B proteaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310701(US10150763, Example A)
Affinity DataIC50:  1.76nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124206(US8748458, 14)
Affinity DataIC50:  2nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50485229(CHEMBL2041756)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of Human immunodeficiency virus 1 3B proteaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50485228(CHEMBL2041753)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of Human immunodeficiency virus 1 3B proteaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124207(US8748458, 15)
Affinity DataIC50:  3nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50485230(CHEMBL2041754)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of Human immunodeficiency virus 1 3B proteaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of Human immunodeficiency virus 1 3B proteaseMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124199(US8748458, 3)
Affinity DataIC50:  9nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124205(US8748458, 11)
Affinity DataIC50:  13nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124200(US8748458, 4)
Affinity DataIC50:  16nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124202(US8748458, 8)
Affinity DataIC50:  19nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124201(US8748458, 5)
Affinity DataIC50:  22nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124203(US8748458, 9)
Affinity DataIC50:  31nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124204(US8748458, 10)
Affinity DataIC50:  57nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124200(US8748458, 4)
Affinity DataIC50:  62nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124206(US8748458, 14)
Affinity DataIC50:  64nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124198(US8748458, 1)
Affinity DataIC50:  68nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124200(US8748458, 4)
Affinity DataIC50:  71nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124200(US8748458, 4)
Affinity DataIC50:  90nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 11(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124200(US8748458, 4)
Affinity DataIC50:  112nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124202(US8748458, 8)
Affinity DataIC50:  116nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 5(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124200(US8748458, 4)
Affinity DataIC50:  123nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124200(US8748458, 4)
Affinity DataIC50:  126nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124206(US8748458, 14)
Affinity DataIC50:  145nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124207(US8748458, 15)
Affinity DataIC50:  151nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 7(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124200(US8748458, 4)
Affinity DataIC50:  157nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124198(US8748458, 1)
Affinity DataIC50:  158nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124204(US8748458, 10)
Affinity DataIC50:  182nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124205(US8748458, 11)
Affinity DataIC50:  182nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124200(US8748458, 4)
Affinity DataIC50:  212nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310701(US10150763, Example A)
Affinity DataIC50:  226nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124206(US8748458, 14)
Affinity DataIC50:  306nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124199(US8748458, 3)
Affinity DataIC50:  307nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124200(US8748458, 4)
Affinity DataIC50:  312nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124207(US8748458, 15)
Affinity DataIC50:  423nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124203(US8748458, 9)
Affinity DataIC50:  453nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124199(US8748458, 3)
Affinity DataIC50:  458nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 5(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124199(US8748458, 3)
Affinity DataIC50:  458nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310725(7-((4-(4-Fluorophenyl)pyridin-2-yl)(1-methyl-1H-py...)
Affinity DataIC50: <500nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310726(8-((4-(4-Fluorophenyl)pyridin-2-yl)(1-methyl-1H-py...)
Affinity DataIC50: <500nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310727(7-((5-Fluoropyridin-2-yl)(3-(trifluoromethyl)1,2,4...)
Affinity DataIC50: <500nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310728(8-((5-Fluoropyridin-2-yl)(3-(trifluoromethyl)1,2,4...)
Affinity DataIC50: <500nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310729(7-((5-Fluoropyridin-2-yl)(3-methyl-1,2,4-thiadiazo...)
Affinity DataIC50: <500nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310730(8-((5-Fluoropyridin-2-yl)(3-methyl-1,2,4-thiadiazo...)
Affinity DataIC50: <500nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310731(7-((4-(4-Fluorophenyl)pyridin-2-yl)(3-methyl-1,2,4...)
Affinity DataIC50: <500nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310732(8-((4-(4-Fluorophenyl)-pyridin-2-yl)(3-methyl-1,2,...)
Affinity DataIC50: <500nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310733(7-((5-Fluoropyridin-2-yl)(3-(trifluoromethyl)1,2,4...)
Affinity DataIC50: <500nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310734(8-((5-Fluoropyridin-2-yl)(3-(trifluoromethyl)1,2,4...)
Affinity DataIC50: <500nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310735(7-(Benzo[d]thiazol-2-yl(pyridin-2-yl)amino)-N-hydr...)
Affinity DataIC50: <500nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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