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Found 1228 with Last Name = 'tortorella' and Initial = 'p'
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12072((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12075((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataKi:  4.40nM ΔG°:  -47.7kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12072((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataKi:  5nM ΔG°:  -47.4kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12072((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataKi:  40nM ΔG°:  -42.2kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12074((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataKi:  54.9nM ΔG°:  -41.4kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataKi:  74nM ΔG°:  -40.3kJ/molepH: 7.5 T: 2°CAssay Description:The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKi:  88nM ΔG°:  -39.9kJ/molepH: 7.5 T: 2°CAssay Description:The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKi:  88nMAssay Description:Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc...More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12073((S)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataKi:  700nM ΔG°:  -35.1kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28763((2S)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKi:  971nMAssay Description:Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28763((2S)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKi:  971nM ΔG°:  -34.0kJ/molepH: 7.5 T: 2°CAssay Description:The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12073((S)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataKi:  1.20E+3nM ΔG°:  -33.8kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50:  0.0460nMAssay Description:Inhibition of human recombinant MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198038(CHEMBL227824 | [(R)-1-(4'-ethoxy-biphenyl-4-sulfon...)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198033(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198038(CHEMBL227824 | [(R)-1-(4'-ethoxy-biphenyl-4-sulfon...)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of human recombinant MMP2 expressed in mouse myeloma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198033(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198035(CHEMBL227501 | [(R)-2-methyl-1-(3'-methyl-biphenyl...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM26739(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of FAAH in Wistar rat brain intact neurons assessed as reduction in [3H]anandamide hydrolysis using [3H]anandamide as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198038(CHEMBL227824 | [(R)-1-(4'-ethoxy-biphenyl-4-sulfon...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of human recombinant MMP9 expressed in mouse myeloma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human recombinant MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50593777(CHEMBL5185868)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human AChE by Ellman's spectrophotometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198034(CHEMBL376557 | [(R)-1-(4'-chloro-biphenyl-4-sulfon...)
Affinity DataIC50:  0.810nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50:  1nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198039(CHEMBL374377 | [(R)-1-(4'-fluoro-biphenyl-4-sulfon...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198038(CHEMBL227824 | [(R)-1-(4'-ethoxy-biphenyl-4-sulfon...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198030(CHEMBL228188 | [(R)-1-(3'-chloro-biphenyl-4-sulfon...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12072((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12072((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant MMP2 expressed in mouse myeloma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198031(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198031(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant MMP2 expressed in mouse myeloma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198040(CHEMBL389898 | [(R)-2-methyl-1-(4'-pyrrolidin-1-yl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198033(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant MMP2 expressed in mouse myeloma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198033(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant MMP2 expressed in mouse myeloma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198037(CHEMBL228187 | [(R)-1-(3'-fluoro-biphenyl-4-sulfon...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM12072((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50593778(CHEMBL5189408)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human AChE by Ellman's spectrophotometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12076((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)
Affinity DataIC50:  3nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198033(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198033(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12075((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  4nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50:  4nMpH: 6.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198033(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human recombinant MMP9 expressed in mouse myeloma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198031(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM26739(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of FAAH in Wistar rat brain membranes assessed as reduction in [3H]anandamide hydrolysis using [3H]anandamide as substrate preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12074((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  5nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM50198040(CHEMBL389898 | [(R)-2-methyl-1-(4'-pyrrolidin-1-yl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198034(CHEMBL376557 | [(R)-1-(4'-chloro-biphenyl-4-sulfon...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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