TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 31nMAssay Description:Competitive inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preinc...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 750nMAssay Description:Competitive inhibition of human recombinant AKR1C3 using assessed as reduction in NADPH-dependent reduction of delat4-androsten-3,17-dione preincubat...More data for this Ligand-Target Pair
Affinity DataKi: 1.50E+3nMAssay Description:Binding affinity to wild type human COX2 expressed in insect cells using [1-14C]-arachidonic acid as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1.30E+4nMAssay Description:Binding affinity to wild type human COX2 expressed in insect cells using [1-14C]-arachidonic acid as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:In vitro inhibitory activity of the compound against prostaglandin G/H synthase 2 from ovineMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of ovine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of mouse COX2 using 2-arachidonylglycerol as substrate preincubated for 3 mins followed by substrate addition and measured for 30 sec by L...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of wild type ovine COX1 expressed in ram seminal vesicles using [1-14C]-arachidonic acid as substrate incubated for 17 mins at 25 degC fol...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of COX2 in mouse LPS-stimulated RAW264.7 cells after 30 minsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of mouse purified COX2 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:In vitro inhibitory concentration against ovine Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of ovine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:In vitro inhibitory activity of the compound against prostaglandin G/H synthase 2 from ovineMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:In vitro inhibitory concentration against ovine Cyclooxygenase-2More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:In vitro inhibitory concentration against ovine Cyclooxygenase-2More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of COX2 in mouse LPS-stimulated RAW264.7 cells after 30 minsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of COX-1 in human OVCAR3 cells assessed as [14C] arachidonic acid remaining using [14C] arachidonic acid as substrate preincubated for 30 ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of mouse purified COX2 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of ovine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Each molecule was evaluated for its ability to inhibit purified mouse COX-2 or ovine COX-1 using a previously described assay. [Kalgutkar et al, J. M...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:In vitro inhibition of ovine prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:In vitro inhibitory activity of the compound against prostaglandin G/H synthase 2 from ovineMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse COX-2 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of COX1 in ram seminal vesicles using arachidonic acid as substrate assessed as reduction in PGH2 conversion to PGG2 by measuring TMPD oxi...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:In vitro inhibitory concentration against ovine Cyclooxygenase-2More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:In vitro inhibitory concentration against ovine Cyclooxygenase-2More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of ovine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:In vitro inhibitory concentration against ovine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:In vitro inhibition of ovine prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of ovine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of mouse purified COX2 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2 [18-604,R106Q](Mus musculus (Mouse))
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Affinity DataIC50: 90nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
Affinity DataIC50: 94nMAssay Description:Inhibition of ovine COX-1 assessed as [14C] arachidonic acid remaining using [14C] arachidonic acid as substrate preincubated for 20 mins followed by...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Each molecule was evaluated for its ability to inhibit purified mouse COX-2 or ovine COX-1 using a previously described assay. [Kalgutkar et al, J. M...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 114nMAssay Description:In vitro inhibitory concentration against ovine Cyclooxygenase-2More data for this Ligand-Target Pair
Affinity DataIC50: 114nMAssay Description:In vitro inhibitory concentration against ovine Cyclooxygenase-2More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 127nMAssay Description:Inhibition of wild type mouse COX2 expressed in insect cells using [1-14C]-arachidonic acid as substrate incubated for 17 mins at 25 degC followed by...More data for this Ligand-Target Pair