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Found 103 with Last Name = 'umezawa' and Initial = 'n'
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50586369(CHEMBL5094265)
Affinity DataKi:  5.30nMAssay Description:Inhibition of human LSD1 using K4me2 peptide as substrate measured after 10 mins by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50586368(CHEMBL5073848)
Affinity DataKi:  7.80nMAssay Description:Inhibition of human LSD1 using K4me2 peptide as substrate measured after 10 mins by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50240130(CHEMBL4060961)
Affinity DataKi:  30nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50240124(CHEMBL4090728)
Affinity DataKi:  40nMAssay Description:Inhibition of human LSD1 assessed as reduction in H2O2 production using pLys4Met H3 peptide as substrate by peroxidase coupled UV-visible spectrophot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50240122(CHEMBL4103690)
Affinity DataKi:  60nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetREST corepressor 1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50586370(CHEMBL5084197)
Affinity DataKi:  60nMAssay Description:Inhibition of human LSD1/CoRESTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetREST corepressor 1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50586371(CHEMBL5089876)
Affinity DataKi:  80nMAssay Description:Inhibition of human LSD1/CoRESTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50240126(CHEMBL4105288)
Affinity DataKi:  98nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50586367(CHEMBL5089144)
Affinity DataKi:  100nMAssay Description:Inhibition of human LSD1 using K4me2 peptide as substrate measured after 10 mins by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50586366(CHEMBL5093950)
Affinity DataKi:  100nMAssay Description:Inhibition of human LSD1 using K4me2 peptide as substrate measured after 10 mins by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetREST corepressor 1 [4-485](Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50158884(CHEMBL3785550)
Affinity DataKi:  140nMAssay Description:Inhibition of recombinant human His-tagged LSD1 (171 to 836 residues)/GST-tagged CoREST (308 to 440 residues) complex using H3K4 peptide substrate by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetREST corepressor 1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50586373(CHEMBL5075544)
Affinity DataKi:  170nMAssay Description:Inhibition of human LSD1/CoRESTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50586365(CHEMBL5078239)
Affinity DataKi:  180nMAssay Description:Inhibition of human LSD1 using K4me2 peptide as substrate measured after 10 mins by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50240123(CHEMBL4085763)
Affinity DataKi:  290nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50240121(CHEMBL4089148)
Affinity DataKi:  380nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetREST corepressor 1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50586372(CHEMBL5085737)
Affinity DataKi:  640nMAssay Description:Inhibition of human LSD1/CoRESTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50586364(CHEMBL5084292)
Affinity DataKi:  950nMAssay Description:Inhibition of human LSD1 using K4me2 peptide as substrate measured after 10 mins by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50586363(CHEMBL5079374)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of human LSD1 using K4me2 peptide as substrate measured after 10 mins by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50240129(CHEMBL4080345)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50210048(CHEMBL3884919)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human LSD1 assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50158884(CHEMBL3785550)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of human LSD1 assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50240131(CHEMBL4083113)
Affinity DataKi:  6.30E+3nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50240118(CHEMBL4096854)
Affinity DataKi:  9.80E+3nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50210048(CHEMBL3884919)
Affinity DataKi:  3.70E+4nMAssay Description:Inhibition of human LSD1 assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50210048(CHEMBL3884919)
Affinity DataKi:  4.40E+4nMAssay Description:Inhibition of human LSD1 assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50240125(CHEMBL4081282)
Affinity DataKi:  1.70E+5nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50210049(CHEMBL3885101)
Affinity DataKi:  1.90E+5nMAssay Description:Inhibition of human LSD1 assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50210050(CHEMBL3884529)
Affinity DataKi: >3.00E+5nMAssay Description:Inhibition of human LSD1 assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50210050(CHEMBL3884529)
Affinity DataKi: >3.00E+5nMAssay Description:Inhibition of human LSD1 assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50240117(CHEMBL4069633)
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50240116(CHEMBL4081041)
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50240120(CHEMBL4099300)
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50240119(CHEMBL4104579)
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) assessed as reduction in H2O2 production using H3K4me2 (1 to 20 residues) peptide as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490579(CHEMBL2337154)
Affinity DataIC50:  0.402nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490580(CHEMBL2337153)
Affinity DataIC50:  0.555nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490579(CHEMBL2337154)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490580(CHEMBL2337153)
Affinity DataIC50:  0.880nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490588(CHEMBL2336728)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490580(CHEMBL2337153)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of notch intracel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490588(CHEMBL2336728)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490578(CHEMBL2337566)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490578(CHEMBL2337566)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490578(CHEMBL2337566)
Affinity DataIC50:  20nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of notch intracel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490579(CHEMBL2337154)
Affinity DataIC50:  41nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of notch intracel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50138983((S)-2-Amino-5-(2-methyl-isothioureido)-pentanoic a...)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration against human neuronal nitric oxide synthase expressed in Sf-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490580(CHEMBL2337153)
Affinity DataIC50:  68nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of Abeta42 secret...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490579(CHEMBL2337154)
Affinity DataIC50:  84nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of IAbeta40 secre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490580(CHEMBL2337153)
Affinity DataIC50:  85nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of IAbeta40 secre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490579(CHEMBL2337154)
Affinity DataIC50:  86nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of Abeta42 secret...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM28922((2S)-N-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-h...)
Affinity DataIC50:  203nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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