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Found 130 with Last Name = 'vacek' and Initial = 'ep'
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091753(CHEMBL405854 | H-Ser-Leu-Arg-Arg-Ser-Ser-cyclic(Cy...)
Affinity DataKi:  0.0590nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061031((S)-1-[(S)-2-(4-Benzenesulfonylaminocarbonyl-benzo...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091751(CHEMBL411542 | Cyclic-(Cys-Phe-Gly-Gly-Arg-Ile-Asp...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091751(CHEMBL411542 | Cyclic-(Cys-Phe-Gly-Gly-Arg-Ile-Asp...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091758((S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbam...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091758((S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbam...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50009073(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Affinity DataKi:  0.340nMAssay Description:Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranesMore data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061028((S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-but...)
Affinity DataKi:  0.350nMAssay Description:In vitro inhibitory activity against human leukocyte elastase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061028((S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-but...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061047(((S)-2,2-Difluoro-5-methyl-4-{[(S)-1-((S)-3-methyl...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061043(CHEMBL106592 | [(S)-1-((S)-2-{(S)-3,3-Difluoro-1-i...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061037(CHEMBL302961 | {(S)-1-[(S)-2-((S)-3-Carbamoyl-3,3-...)
Affinity DataKi:  0.380nMAssay Description:In vitro inhibitory activity against human leukocyte elastase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061037(CHEMBL302961 | {(S)-1-[(S)-2-((S)-3-Carbamoyl-3,3-...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50041356(1-Ethyl-3-[2-methoxy-4-(toluene-2-sulfonylaminocar...)
Affinity DataKi:  0.380nMAssay Description:Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50283099(((S)-2,2-Difluoro-5-methyl-4-{[(S)-1-((S)-3-methyl...)
Affinity DataKi:  0.390nMAssay Description:In vitro inhibitory activity against human leukocyte elastase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091752((S)-3-{(2S,3S)-2-[(S)-5-Guanidino-2-(2-{4-[(naphth...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091752((S)-3-{(2S,3S)-2-[(S)-5-Guanidino-2-(2-{4-[(naphth...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50041349(3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)-b...)
Affinity DataKi:  0.420nMAssay Description:Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50041357(1-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)-b...)
Affinity DataKi:  0.440nMAssay Description:Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091761((S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbam...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091757(CHEMBL264744 | Cyclic-(Cys-Phe-Gly-Gly-Ala-Ile-Asp...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091757(CHEMBL264744 | Cyclic-(Cys-Phe-Gly-Gly-Ala-Ile-Asp...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50041344(3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)-b...)
Affinity DataKi:  0.570nMAssay Description:Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50041336(3-[4-(2-Chloro-benzenesulfonylaminocarbonyl)-2-met...)
Affinity DataKi:  0.570nMAssay Description:Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031210(2-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-3-m...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061035(2-((S)-3-Methyl-2-{[(S)-1-((S)-3-methyl-2-phenoxyc...)
Affinity DataKi:  0.640nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061044(2-((S)-3-Methyl-2-{[(S)-1-((S)-3-methyl-2-phenoxyc...)
Affinity DataKi:  0.640nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50283102((S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-but...)
Affinity DataKi:  0.650nMAssay Description:In vitro inhibitory activity against human leukocyte elastase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061049(2-[(S)-2-({(S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3...)
Affinity DataKi:  0.650nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091753(CHEMBL405854 | H-Ser-Leu-Arg-Arg-Ser-Ser-cyclic(Cy...)
Affinity DataKi:  0.650nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035948(2-[3-(4-Acetylamino-benzenesulfonylamino)-2-oxo-6-...)
Affinity DataKi:  0.700nMAssay Description:In vitro inhibition constant (Ki) against human leukocyte elastase (HLE-catalyzed hydrolysis of MeO-Suc-Ala-Ala-Pro-Ala-pNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061054(CHEMBL110125 | CHEMBL66128 | {(S)-1-[(S)-2-((S)-4-...)
Affinity DataKi:  0.810nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061054(CHEMBL110125 | CHEMBL66128 | {(S)-1-[(S)-2-((S)-4-...)
Affinity DataKi:  0.810nMAssay Description:In vitro inhibitory activity against human leukocyte elastase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061036(CHEMBL304114 | {(S)-1-[(S)-2-((S)-3,3-Difluoro-1-i...)
Affinity DataKi:  0.850nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061036(CHEMBL304114 | {(S)-1-[(S)-2-((S)-3,3-Difluoro-1-i...)
Affinity DataKi:  0.850nMAssay Description:In vitro inhibitory activity against human leukocyte elastase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061027(((S)-4-{[(S)-1-((S)-2-Benzyloxycarbonylamino-3-met...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50283092(((S)-4-{[(S)-1-((S)-2-Benzyloxycarbonylamino-3-met...)
Affinity DataKi:  1.10nMAssay Description:In vitro inhibitory activity against human leukocyte elastase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50041350(3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)-b...)
Affinity DataKi:  1.20nMAssay Description:Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50041352(3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)-b...)
Affinity DataKi:  1.30nMAssay Description:Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058344(CHEMBL417935 | {(S)-2-Methyl-1-[(S)-2-((S)-3,3,3-t...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50041339(3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)-b...)
Affinity DataKi:  1.5nMAssay Description:Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061023(CHEMBL323231 | CHEMBL68577 | {(S)-1-[(S)-2-((S)-4-...)
Affinity DataKi:  1.60nMAssay Description:In vitro inhibitory activity against human leukocyte elastase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061023(CHEMBL323231 | CHEMBL68577 | {(S)-1-[(S)-2-((S)-4-...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091754(Arg-Ser-Ser-cyclic-(Cys-Phe-Gly-Gly-Arg-Ile-Asp-Ar...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50041353(3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)-b...)
Affinity DataKi:  1.70nMAssay Description:Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061052(CHEMBL110364 | [(S)-1-((S)-2-{(S)-3,3-Difluoro-1-i...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061040(CHEMBL2370419 | {(S)-2-Methyl-1-[(S)-2-(3,3,3-trif...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058391((S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-but...)
Affinity DataKi:  1.90nMAssay Description:In vitro inhibition constant (Ki) against human leukocyte elastase (HLE-catalyzed hydrolysis of MeO-Suc-Ala-Ala-Pro-Ala-pNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50041348(3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)-b...)
Affinity DataKi:  2.10nMAssay Description:Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50041360(3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)-b...)
Affinity DataKi:  2.20nMAssay Description:Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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