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Found 170 with Last Name = 'vanella' and Initial = 'l'
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206591(CHEMBL375499 | methyl (1R,2S/1S,2R)-2-[(4-benzylpi...)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206586(CHEMBL225516 | methyl (1R,2S/1S,2R)-2-[(4-benzylpi...)
Affinity DataKi:  0.820nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206593(CHEMBL374686 | methyl (1R,2S/1S,2R)-2-[(4-benzylpi...)
Affinity DataKi:  0.970nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206579(CHEMBL426724 | methyl (1R,2S/1S,2R)-2-[(4-benzylpi...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206578(CHEMBL222301 | cis-((+/-)-Methyl(1R,2S/1S,2R)-2-[(...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206589(CHEMBL222445 | methyl (1R,2S/1S,2R)-1-(4-chlorophe...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206585(CHEMBL222235 | methyl (1R,2S/1S,2R)-2-[(4-hydroxy-...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206580(CHEMBL222236 | methyl (1R,2S/1S,2R)-2-[(4-benzylpi...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206590(CHEMBL385795 | methyl (1R,2S/1S,2R)-2-[(4-hydroxy-...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50035131((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206597(CHEMBL221348 | methyl (1R,2S/1S,2R)-2-[(4-Hydroxy-...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM81982(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50017376((+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylm...)
Affinity DataKi:  78nMAssay Description:Binding affinity to human ERG assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206577(10-methoxyibogamine | CHEMBL222287 | IBOGAINE)
Affinity DataKi:  250nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206596(CHEMBL221347 | methyl (1R,2S/1S,2R)-1-(4-chlorophe...)
Affinity DataKi:  350nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206582(CHEMBL222394 | methyl (1R,2S/1S,2R)-1-(4-methylphe...)
Affinity DataKi:  353nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206595(CHEMBL386002 | methyl (1R,2S/1S,2R)-1-(4-methylphe...)
Affinity DataKi:  497nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206598(CHEMBL225653 | methyl (1R,2S/1S,2R)-(4-nitrophenyl...)
Affinity DataKi:  619nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206594(CHEMBL222307 | methyl (1R,2S/1S,2R)-1-(4-chlorophe...)
Affinity DataKi:  707nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206576(CHEMBL222444 | methyl (1R,2S/1S,2R)-1-(4-nitrophen...)
Affinity DataKi:  769nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206592(CHEMBL386931 | methyl (1R,2S/1S,2R)-1-(4-methoxyph...)
Affinity DataKi:  1.26E+3nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206578(CHEMBL222301 | cis-((+/-)-Methyl(1R,2S/1S,2R)-2-[(...)
Affinity DataKi:  1.29E+3nMAssay Description:Displacement of [3H]spiperone from rat striatum dopamine D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206587(CHEMBL222736 | methyl (1R,2S/1S,2R)-1-phenyl-2-[(4...)
Affinity DataKi:  1.33E+3nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206578(CHEMBL222301 | cis-((+/-)-Methyl(1R,2S/1S,2R)-2-[(...)
Affinity DataKi:  1.42E+3nMAssay Description:Displacement of [3H]pyrilamine from rat cortex histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206584(CHEMBL434385 | methyl (1R,2S/1S,2R)-1-(4-methoxyph...)
Affinity DataKi:  2.03E+3nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206583(CHEMBL373686 | methyl (1R,2S/1S,2R)-1-phenyl-2-[(4...)
Affinity DataKi:  3.09E+3nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206578(CHEMBL222301 | cis-((+/-)-Methyl(1R,2S/1S,2R)-2-[(...)
Affinity DataKi:  3.15E+3nMAssay Description:Displacement of [3H]ketanserin from rat cortex 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206578(CHEMBL222301 | cis-((+/-)-Methyl(1R,2S/1S,2R)-2-[(...)
Affinity DataKi:  4.36E+3nMAssay Description:Displacement of [3H]mesulergine from guinea pig cortex 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206578(CHEMBL222301 | cis-((+/-)-Methyl(1R,2S/1S,2R)-2-[(...)
Affinity DataKi:  4.90E+3nMAssay Description:Displacement of [3H]-7OH-DPAT from rat olfactory tubercle dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206578(CHEMBL222301 | cis-((+/-)-Methyl(1R,2S/1S,2R)-2-[(...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]GR13808 from guinea pig cortex 5HT4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206578(CHEMBL222301 | cis-((+/-)-Methyl(1R,2S/1S,2R)-2-[(...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]citalopram from rat cortex SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206578(CHEMBL222301 | cis-((+/-)-Methyl(1R,2S/1S,2R)-2-[(...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]LY278584 from rat cortex 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206578(CHEMBL222301 | cis-((+/-)-Methyl(1R,2S/1S,2R)-2-[(...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH23390 from rat striatum dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206578(CHEMBL222301 | cis-((+/-)-Methyl(1R,2S/1S,2R)-2-[(...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]WIN 35,428 from rat striatum DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206588(CHEMBL374814 | methyl (1R,2S/1S,2R)-1-(4-aminophen...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206578(CHEMBL222301 | cis-((+/-)-Methyl(1R,2S/1S,2R)-2-[(...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-5HT from rat cloned 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50206581(CHEMBL221370 | methyl (1R,2S/1S,2R)-1-(4-aminophen...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H](+)pentazocine from guinea pig brain sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308587(8-[(5-Chloro-2-piperazin-1-ylisonicotinoyl)amino]-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant IKK2-mediated transfer of [gamma33P]ATP to biotinylated IkappaBalpha after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  18nMAssay Description:Inhibition of CYP2D6 (unknown origin) using quinidine as substrateMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308599(8-({5-Chloro-2-[[2-(dimethylamino)ethyl]-(methyl)a...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant IKK2-mediated transfer of [gamma33P]ATP to biotinylated IkappaBalpha after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308585(8-{[5-Chloro-2-(4-methylpiperazin-1-yl)isonicotino...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant IKK2-mediated transfer of [gamma33P]ATP to biotinylated IkappaBalpha after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308598(8-{[5-Chloro-2-(1,4-diazepan-1-yl)isonicotinoyl]am...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant IKK2-mediated transfer of [gamma33P]ATP to biotinylated IkappaBalpha after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308597(8-{[5-Chloro-2-(4-methyl-1,4-diazepan-1-yl)isonico...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human recombinant IKK2-mediated transfer of [gamma33P]ATP to biotinylated IkappaBalpha after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308584(1-(1,3-Benzodioxol-5-yl)-8-{[5-chloro-2-(4-methylp...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human recombinant IKK2-mediated transfer of [gamma33P]ATP to biotinylated IkappaBalpha after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308569(1-(benzo[d][1,3]dioxol-5-yl)-8-(2-chloronicotinami...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human recombinant IKK2-mediated transfer of [gamma33P]ATP to biotinylated IkappaBalpha after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308586(1-(1,3-Benzodioxol-5-yl)-8-[(5-chloro-2-piperazin-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant IKK2-mediated transfer of [gamma33P]ATP to biotinylated IkappaBalpha after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308595(8-({5-Chloro-2-[(3S)-3,4-dimethylpiperazin-1-yl]is...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant IKK2-mediated transfer of [gamma33P]ATP to biotinylated IkappaBalpha after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)
Affinity DataIC50:  46nMAssay Description:Inhibition of CYP3A4 (unknown origin) using ketoconazole as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308592(8-({5-Chloro-2-[(3R,5S)-3,5-dimethylpiperazin-1-yl...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human recombinant IKK2-mediated transfer of [gamma33P]ATP to biotinylated IkappaBalpha after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308574(8-(2-chloronicotinamido)-1-(4-fluorophenyl)-4,5-di...)
Affinity DataIC50:  47nMAssay Description:Inhibition of human recombinant IKK2-mediated transfer of [gamma33P]ATP to biotinylated IkappaBalpha after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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