Affinity DataIC50: 0.400nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite De Montreal At Succursale Centre-Ville
Universite De Montreal At Succursale Centre-Ville
Affinity DataIC50: 0.600nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrateMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells assessed as reduction in amyloid beta42 levelMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells assessed as reduction in amyloid beta(1 to 40 residues) levelMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells incubated for 24 hrs by immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells incubated for 24 hrs by immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type human APP expressed in CHO cells assessed as reduction in amyloid beta 40 secretion incubated for 24 hrs by immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type human APP expressed in CHO cells assessed as reduction in amyloid beta 42 secretion incubated for 24 hrs by immunoassayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in CHO cells co-expressing human APP751 assessed as decrease in amyloid beta 40 levels after 24 hrs by...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in CHO cells co-expressing human APP751 assessed as decrease in amyloid beta 40 levels after 24 hrs by...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Binding affinity against NK1 receptor by displacement of [3H]-SP from bovine retina membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells assessed as reduction in amyloid beta40 levelMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type human APP expressed in CHO cells assessed as reduction in soluble APP beta level incubated for 24 hrs by immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells incubated for 24 hrs by immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells incubated for 24 hrs by immunoassayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in CHO cells co-expressing human APP751 assessed as decrease in amyloid beta 40 levels after 24 hrs by...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in CHO cells co-expressing human APP751 assessed as decrease in amyloid beta 40 levels after 24 hrs by...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in CHO cells co-expressing human APP751 assessed as decrease in amyloid beta 40 levels after 24 hrs by...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 1 nM concentrations is incubated wi...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair