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Found 1215 with Last Name = 'wang' and Initial = 'sy'
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM50471134(CHEMBL64664)
Affinity DataKi:  0.0140nMAssay Description:Displacement of 2-[125I]iodomelatonin from melatonin receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM50506044(CHEMBL4531537)
Affinity DataKi:  0.0440nMAssay Description:Displacement of 2-[125I]iodomelatonin from melatonin receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080882(Benzamidrazone analogue | CHEMBL312244)
Affinity DataKi:  0.0600nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080879(Benzamidrazone analogue | CHEMBL82057)
Affinity DataKi:  0.100nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM50506042(CHEMBL4467954)
Affinity DataKi:  0.150nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.180nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMelatonin receptor type 1B(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.180nMAssay Description:Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMelatonin receptor type 1B(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM50506042(CHEMBL4467954)
Affinity DataKi:  0.190nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM50043289(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM50086029(CHEMBL10099 | N-[2-(10-Methoxy-5,6-dihydro-indolo[...)
Affinity DataKi:  0.200nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080885(Benzamidrazone analogue | CHEMBL79304)
Affinity DataKi:  0.200nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080883(Benzamidrazone analogue | CHEMBL310664)
Affinity DataKi:  0.200nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.204nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM50506045(CHEMBL4475742)
Affinity DataKi:  0.230nMAssay Description:Displacement of 2-[125I]iodomelatonin from melatonin receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM85066(Luzindole,5-Methoxy)
Affinity DataKi:  0.25nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.302nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMelatonin receptor type 1B(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.330nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMelatonin receptor type 1C(Gallus gallus)
Nantong University

Curated by ChEMBL
LigandPNGBDBM50472142(CHEMBL142343)
Affinity DataKi:  0.378nMAssay Description:Displacement of 2-[125I]iodomelatonin from chick brain melatonin receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069294((S)-3-[4-(carbohydrazonamidol)-phenyl]-N-cyclopent...)
Affinity DataKi:  0.380nMAssay Description:Compound was tested for inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069294((S)-3-[4-(carbohydrazonamidol)-phenyl]-N-cyclopent...)
Affinity DataKi:  0.380nMAssay Description:Compound was evaluated for its inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069294((S)-3-[4-(carbohydrazonamidol)-phenyl]-N-cyclopent...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085048((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)
Affinity DataKi:  0.430nMAssay Description:Binding affinity to PPARgamma (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.460nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070780((S)-3-(5-Carbamimidoyl-thiophen-2-yl)-N-cyclopenty...)
Affinity DataKi:  0.490nMAssay Description:Compound was evaluated for its inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080888(Benzamidrazone analogue | CHEMBL84454)
Affinity DataKi:  0.5nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1C(Gallus gallus)
Nantong University

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.590nMAssay Description:Displacement of 2-[125I]iodomelatonin from chick brain melatonin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070785((S)-3-(5-Carbamimidoyl-thiophen-2-yl)-N-cyclopenty...)
Affinity DataKi:  0.600nMAssay Description:Compound was evaluated for its inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.610nMAssay Description:Displacement of 2-[125I]iodomelatonin from melatonin receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMelatonin receptor type 1A(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.660nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080886(Benzamidrazone analogue | CHEMBL313296)
Affinity DataKi:  0.700nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM28661(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Affinity DataKi:  0.820nMAssay Description:Binding affinity to PPARdelta (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070782((S)-3-(4-Carbamimidoyl-phenyl)-N-cyclopentyl-N-met...)
Affinity DataKi:  0.840nMAssay Description:Compound was evaluated for its inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.880nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMelatonin receptor type 1A(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.880nMAssay Description:Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080884(Benzamidrazone analogue | CHEMBL314189)
Affinity DataKi:  0.900nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.950nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085048((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)
Affinity DataKi:  1nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Lanthascreen TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50291355(1-[3-[4-amino(amineimino)methylphenyl]-2-(2-anthry...)
Affinity DataKi:  1nMAssay Description:Inhibitory effect against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50069294((S)-3-[4-(carbohydrazonamidol)-phenyl]-N-cyclopent...)
Affinity DataKi:  1.10nMAssay Description:Compound was tested for inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50099491(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to PPARalpha (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM50506043(CHEMBL4548591)
Affinity DataKi:  1.40nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50069297(1-[3-[4-amino(amineimino)methylphenyl]-2-(2-naphth...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory effect against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080880(Benzamidrazone analogue | CHEMBL312011)
Affinity DataKi:  1.80nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080881(Benzamidrazone analogue | CHEMBL82072)
Affinity DataKi:  2nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070784((S)-3-(5-Carbamimidoyl-thiophen-2-yl)-N-cyclopenty...)
Affinity DataKi:  3nMAssay Description:Compound was evaluated for its inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50069292(CHEMBL156082 | N-ethyl-N-cyclopentyl-3-(4-hydrazon...)
Affinity DataKi:  4nMAssay Description:Compound was tested for inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM50086029(CHEMBL10099 | N-[2-(10-Methoxy-5,6-dihydro-indolo[...)
Affinity DataKi:  4.10nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Harbin Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50095155((S)-1-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyl]...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]DAMGO from MOR in Wistar rat brain membranes measured after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50076722((S)-5-(4-Methylamino-phenyl)-2-(5,6,7,8-tetrahydro...)
Affinity DataKi:  5nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Nantong University

Curated by ChEMBL
LigandPNGBDBM82509(Melatonin,6-Hydroxy | melatonin, 6-Hydroxy)
Affinity DataKi:  5.5nMAssay Description:Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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