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Found 509 with Last Name = 'westkaemper' and Initial = 'rb'
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292914(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.0700nMAssay Description:Activity at monocloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292918(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]naloxone from monocloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292916(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]naloxone from monocloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292915(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.120nMAssay Description:Activity at monocloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292922(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.140nMAssay Description:Activity at monocloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292923(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.150nMAssay Description:Activity at monocloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292917(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]naloxone from monocloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]naloxone from monocloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50064708((R)-1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine ...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292920(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]naloxone from monocloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50247803(Beta-Funeltrexamine | CHEMBL473136 | beta-funaltre...)
Affinity DataKi:  0.410nMAssay Description:Activity at monocloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292921(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.480nMAssay Description:Activity at monocloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Virginia Commonwealth University

LigandPNGBDBM35928(3-(9,10-dihydroanthracen-9-yl)-N,N-dimethylpropan-...)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/moleT: 2°CAssay Description:Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292919(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [3H]naloxone from monocloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292914(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]norBNI from monocloned kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor [D138N](Homo sapiens (Human))
University Of North Carolina

LigandPNGBDBM50159165((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataKi:  0.590nM ΔG°:  -52.7kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50130263(4-[3-(2-Dimethylamino-ethyl)-5-methoxy-indole-1-su...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity against 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50097218(4-(10H-Anthracen-9-ylidene)-1-methyl-piperidine | ...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor expressed NIH3T3 cells using [3H]-ketanserinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50093055(CHEMBL443796 | {2-[5-Methoxy-1-(naphthalene-1-sulf...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity against 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM28582(1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | CHE...)
Affinity DataKi:  0.920nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50235942(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.920nMAssay Description:Activity at monocloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50247803(Beta-Funeltrexamine | CHEMBL473136 | beta-funaltre...)
Affinity DataKi:  0.940nMAssay Description:Displacement of [3H]norBNI from monocloned kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50131085(3-Bromo-9-aminomethyl-9,10-dihydroanthracene | C-(...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptor sites by using [3H]-Ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50131085(3-Bromo-9-aminomethyl-9,10-dihydroanthracene | C-(...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50235940(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  1.40nMAssay Description:Activity at monocloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50017721(1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)pipe...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2A receptor expressed NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292918(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]norBNI from monocloned kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50017721(1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)pipe...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor from rat forebrain using [3H]-ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50093054(CHEMBL75010 | {2-[5-Methoxy-1-(naphthalene-2-sulfo...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity against 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292915(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]norBNI from monocloned kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50274042((S)-1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine ...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM34141(CHEMBL76237 | MS-245)
Affinity DataKi:  2nMAssay Description:Binding affinity against 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292925((4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)...)
Affinity DataKi:  2nMAssay Description:Activity at monocloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor [K227A](Homo sapiens (Human))
University Of North Carolina

LigandPNGBDBM214798(Dynorphin A (1-17) | YGGFLRRIRPKLK)
Affinity DataKi:  2.20nM ΔG°:  -49.4kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50150981(CHEMBL365040 | [2-(1-Benzenesulfonyl-5-methoxy-2-p...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity against 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor [K227A](Homo sapiens (Human))
University Of North Carolina

LigandPNGBDBM21130(N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl...)
Affinity DataKi:  2.5nM ΔG°:  -49.1kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50014997(1-(4-hexyl-2,5-dimethoxyphenyl)propan-2-amine | 2-...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50014997(1-(4-hexyl-2,5-dimethoxyphenyl)propan-2-amine | 2-...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptor sites by using [3H]-Ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50097224(1-Methyl-4-thioxanthen-9-ylidene-piperidine | 1-me...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor from rat forebrain using [3H]-ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292924(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  2.70nMAssay Description:Activity at monocloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Virginia Commonwealth University

LigandPNGBDBM35927(3-(9,10-dihydroanthracen-9-yl)-N-methylpropan-1-am...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/moleT: 2°CAssay Description:Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50017721(1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)pipe...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptor using [3H]-ketanserinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50131083(3-(3-Phenylpropyl)-9-aminomethyl-9,10-dihydroanthr...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50131083(3-(3-Phenylpropyl)-9-aminomethyl-9,10-dihydroanthr...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptor sites by using [3H]-Ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50131085(3-Bromo-9-aminomethyl-9,10-dihydroanthracene | C-(...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]mesulergine from 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor [K212A](Homo sapiens (Human))
University Of North Carolina

LigandPNGBDBM21130(N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl...)
Affinity DataKi:  3.30nM ΔG°:  -48.4kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor [D138A](Homo sapiens (Human))
University Of North Carolina

LigandPNGBDBM50159165((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataKi:  3.5nM ΔG°:  -48.3kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor [I294A](Homo sapiens (Human))
University Of North Carolina

LigandPNGBDBM50159165((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataKi:  3.90nM ΔG°:  -48.0kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292916(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]NTI from monocloned delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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