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Found 491 with Last Name = 'wilson' and Initial = 'f'
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50315314(8-chloro-4-(4-methylpiperazin-1-yl)benzofuro[3,2-d...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]histamine human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]histamine human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]histamine human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291126(CHEMBL265735 | CHEMBL3856136 | Interleukin-8 inhib...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of Interleukin-8 (IL-8)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterleukin-8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291124(CHEMBL3856133 | CHEMBL411572 | Interleukin-8 inhib...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of Interleukin-8 (IL-8)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterleukin-8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291119(CHEMBL267510 | CHEMBL3856125 | Interleukin-8 inhib...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of Interleukin-8 (IL-8)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterleukin-8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291118(CHEMBL3856131 | CHEMBL438589 | Interleukin-8 inhib...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of Interleukin-8 (IL-8)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterleukin-8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291131(CHEMBL3856127 | CHEMBL413247 | Interleukin-8 inhib...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of Interleukin-8 (IL-8)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterleukin-8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291125(CHEMBL3856135 | CHEMBL411548 | Interleukin-8 inhib...)
Affinity DataKi:  9.30E+3nMAssay Description:Inhibition of Interleukin-8 (IL-8)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterleukin-8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291120(CHEMBL3856128 | CHEMBL410171 | Interleukin-8 inhib...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of Interleukin-8 (IL-8)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterleukin-8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291122(CHEMBL3856126 | CHEMBL428324 | Interleukin-8 inhib...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of Interleukin-8 (IL-8)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterleukin-8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50213962(CHEMBL410765)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of Interleukin-8 (IL-8)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterleukin-8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291128(CHEMBL267749 | CHEMBL3856129 | Interleukin-8 inhib...)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of Interleukin-8 (IL-8)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterleukin-8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291130(CHEMBL3856130 | CHEMBL405300 | Interleukin-8 inhib...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of Interleukin-8 (IL-8)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterleukin-8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291123(CHEMBL3856132 | CHEMBL410211 | Interleukin-8 inhib...)
Affinity DataKi:  3.10E+4nMAssay Description:Inhibition of Interleukin-8 (IL-8)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterleukin-8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291121(CHEMBL2370828 | CHEMBL3856124 | Interleukin-8 inhi...)
Affinity DataKi:  1.06E+5nMAssay Description:Inhibition of Interleukin-8 (IL-8)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterleukin-8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291129(CHEMBL2370827 | CHEMBL3856134 | Interleukin-8 inhi...)
Affinity DataKi:  3.83E+5nMAssay Description:Inhibition of Interleukin-8 (IL-8)More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50315348((R)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051826(CHEMBL27486 | [(S)-4-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]-FPP incorporation into Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051825(CHEMBL27141 | [(S)-4-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]-FPP incorporation into Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051823(CHEMBL275378 | [(S)-4-((R)-2-Amino-3-mercapto-prop...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]-FPP incorporation into Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50315348((R)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Affinity DataIC50:  3nMAssay Description:Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Roche Discover Welwyn

Curated by ChEMBL
LigandPNGBDBM50096729((S)-4-((S)-1-{(S)-1-[(S)-1-((R)-1-Benzylaminooxaly...)
Affinity DataIC50:  4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50315349((S)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Affinity DataIC50:  4nMAssay Description:Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Roche Discover Welwyn

Curated by ChEMBL
LigandPNGBDBM50096734((S)-4-[(S)-3-Carboxy-2-(3-carboxy-propionylamino)-...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Roche Discover Welwyn

Curated by ChEMBL
LigandPNGBDBM50096726(4-[3-Carboxy-2-(3-carboxy-propionylamino)-propiony...)
Affinity DataIC50:  4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Roche Discover Welwyn

Curated by ChEMBL
LigandPNGBDBM50096730(4-[3-Carboxy-2-(3-carboxy-propionylamino)-propiony...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051824(CHEMBL283208 | [(S)-4-((R)-2-Amino-3-mercapto-prop...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [3H]-FPP incorporation into Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Roche Discover Welwyn

Curated by ChEMBL
LigandPNGBDBM50096727((S)-4-[(S)-3-Carboxy-2-(3-carboxy-propionylamino)-...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Roche Discover Welwyn

Curated by ChEMBL
LigandPNGBDBM50096728((S)-4-((S)-1-{(S)-1-[(S)-1-((S)-1-Amino-2-carbamoy...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Roche Discover Welwyn

Curated by ChEMBL
LigandPNGBDBM50096733(4-[3-Carboxy-2-(3-carboxy-propionylamino)-propiony...)
Affinity DataIC50:  7nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Roche Discover Welwyn

Curated by ChEMBL
LigandPNGBDBM50096725(4-[3-Carboxy-2-(3-carboxy-propionylamino)-propiony...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against delta receptor of (endomorphin 2) in mouse vas deferens was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Roche Discover Welwyn

Curated by ChEMBL
LigandPNGBDBM50096732(4-[3-Carboxy-2-(3-carboxy-propionylamino)-propiony...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140854(8-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140848(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Roche Discover Welwyn

Curated by ChEMBL
LigandPNGBDBM50096724((S)-4-((S)-1-{(S)-1-[(S)-1-((R)-1-Aminooxalyl-pent...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140835(8-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140849(8-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140840((4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50315349((S)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140867(9-Chloro-4-{4-[2-(3,4-difluoro-phenyl)-ethyl]-pipe...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140839(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140877((4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140850(9-Chloro-4-{4-[2-(3,4-difluoro-phenyl)-ethyl]-pipe...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50315314(8-chloro-4-(4-methylpiperazin-1-yl)benzofuro[3,2-d...)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140863(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140846(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140880(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140875(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051821(CHEMBL282379 | [(S)-4-((R)-2-Amino-3-mercapto-prop...)
Affinity DataIC50:  24nMAssay Description:Inhibition of [3H]-FPP incorporation into Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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