TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 420nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 480nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 490nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 680nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 690nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 790nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 820nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 930nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 960nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of TPA-induced AP-1 activation in cells expressing beta-lactamase after 18 hrs using FRET substrate by cell-based high-throughput screenin...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of TPA-induced AP-1 activation in cells expressing beta-lactamase after 18 hrs using FRET substrate by cell-based high-throughput screenin...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of AP1 expressed in HEK293T cells coexpressing beta-lactamase pre-incubated 1 hr before TPA addition measured 18 hrs post TPA challenge by...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Nci-Frederick
Curated by ChEMBL
Nci-Frederick
Curated by ChEMBL
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of AP1 expressed in HEK293T cells coexpressing beta-lactamase pre-incubated 1 hr before TPA addition measured 18 hrs post TPA challenge by...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Nci-Frederick
Curated by ChEMBL
Nci-Frederick
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair