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Found 40 with Last Name = 'wisastra' and Initial = 'r'
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Groningen Research Institute Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50401193(CHEMBL1934604)
Affinity DataKi:  9.80E+3nMAssay Description:Inhibition of soyabean lipoxygenase-1 assessed as inhibition constant for enzyme-inhibitor complex by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Groningen Research Institute Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50401193(CHEMBL1934604)
Affinity DataKi:  1.57E+4nMAssay Description:Inhibition of soyabean lipoxygenase-1 assessed as inhibition constant for enzyme-substrate-inhibitor complex by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50444319(CHEMBL3094153)
Affinity DataKi:  7.03E+4nMAssay Description:Binding affinity to human 5-LOX using linoleic acid as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50444319(CHEMBL3094153)
Affinity DataKi:  1.40E+5nMAssay Description:Binding affinity to human 5-LOX-linoleic acid complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Medical Center Groningen

Curated by ChEMBL
LigandPNGBDBM50035507(CHEMBL3355722)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant MMP12 catalytic domain Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-17(Homo sapiens (Human))
University Medical Center Groningen

Curated by ChEMBL
LigandPNGBDBM50035507(CHEMBL3355722)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human recombinant ADAM17 using Mca-PLAQAV-Dpa-RSSSR-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Medical Center Groningen

Curated by ChEMBL
LigandPNGBDBM50035507(CHEMBL3355722)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of human recombinant MMP2 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Medical Center Groningen

Curated by ChEMBL
LigandPNGBDBM50035475(CHEMBL3355723)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant MMP2 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Medical Center Groningen

Curated by ChEMBL
LigandPNGBDBM50035507(CHEMBL3355722)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-17(Homo sapiens (Human))
University Medical Center Groningen

Curated by ChEMBL
LigandPNGBDBM50035475(CHEMBL3355723)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant ADAM17 using Mca-PLAQAV-Dpa-RSSSR-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Medical Center Groningen

Curated by ChEMBL
LigandPNGBDBM50035475(CHEMBL3355723)
Affinity DataIC50:  32nMAssay Description:Inhibition of human recombinant MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Medical Center Groningen

Curated by ChEMBL
LigandPNGBDBM50035475(CHEMBL3355723)
Affinity DataIC50:  138nMAssay Description:Inhibition of human recombinant MMP12 catalytic domain Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  500nMAssay Description:Inhibition of 5-LOXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target72 kDa type IV collagenase(Homo sapiens (Human))
University Medical Center Groningen

Curated by ChEMBL
LigandPNGBDBM50035472(CHEMBL3355724)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of human recombinant MMP2 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247839(CHEMBL447612 | methyl 3-(5-chloro-3-oxoisothiazol-...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247843(CHEMBL510872 | Ethyl 3-(5-chloro-3-oxoisothiazol-2...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Medical Center Groningen

Curated by ChEMBL
LigandPNGBDBM50035472(CHEMBL3355724)
Affinity DataIC50:  2.42E+3nMAssay Description:Inhibition of human recombinant MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247840(CHEMBL489116 | Methyl 4-(5-chloro-3-oxoisothiazol-...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247844(5-Chloro-2-(3-chloro-4-fluorophenyl)isothiazol-3(2...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247845(Benzyl [2-(5-chloro-3-oxoisothiazol-2(3H)-yl)ethyl...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247841(CHEMBL443133 | Methyl 4-(5-chloro-3-oxoisothiazol-...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247837(5-Chloro-2-pentylisothiazol-3(2H)-one | CHEMBL4891...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247838(CHEMBL466866 | Methyl 2-(5-chloro-3-oxoisothiazol-...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247820(5-Chloro-2-ethylisothiazol-3(2H)-one | CHEMBL46147...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247842(CHEMBL442599 | Methyl 6-(5-chloro-3-oxoisothiazol-...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-17(Homo sapiens (Human))
University Medical Center Groningen

Curated by ChEMBL
LigandPNGBDBM50035472(CHEMBL3355724)
Affinity DataIC50:  3.26E+3nMAssay Description:Inhibition of human recombinant ADAM17 using Mca-PLAQAV-Dpa-RSSSR-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247868(2-(3-Chloro-4-fluorophenyl)isothiazol-3(2H)-one | ...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247871(CHEMBL521965 | Methyl 3-[4-{[(benzyloxy)carbonyl]a...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247869(CHEMBL509992 | methyl 3-(5-chloro-1-oxido-3-oxoiso...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247867(CHEMBL500338 | methyl 6-(3-oxoisothiazol-2(3H)-yl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247866(CHEMBL491669 | Methyl 4-(3-oxoisothiazol-2(3H)-yl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247865(CHEMBL450644 | Methyl 3-(3-oxoisothiazol-2(3H)-yl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247864(2-pentylisothiazol-3(2H)-one | CHEMBL491668)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247870(CHEMBL491670 | Methyl 3-[(5-chloroisothiazol-3-yl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50247846(2-Ethylisothiazol-3(2H)-one | CHEMBL490685)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant HAT PCAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Groningen Research Institute Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50401193(CHEMBL1934604)
Affinity DataIC50:  1.11E+4nMAssay Description:Inhibition of soyabean lipoxygenase-1 assessed as formation of 13-HPOD from linolenic acid preincubated for 10 mins measured by real-time spectrophot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable linoleate 9S-lipoxygenase 5(Solanum tuberosum)
Groningen Research Institute Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50240436(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibition of potato 5-lipoxygenase assessed as residual activity preincubated for 10 mins measured by real-time spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Groningen Research Institute Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50240436(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
Affinity DataIC50:  5.19E+4nMAssay Description:Inhibition of soyabean lipoxygenase-1 assessed as formation of 13-HPOD from linolenic acid preincubated for 10 mins measured by real-time spectrophot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Groningen Research Institute Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50401192(CHEMBL418973)
Affinity DataIC50:  5.54E+4nMAssay Description:Inhibition of soyabean lipoxygenase-1 assessed as formation of 13-HPOD from linolenic acid preincubated for 10 mins measured by real-time spectrophot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Groningen Research Institute Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50401191(CHEMBL2206368)
Affinity DataIC50:  5.85E+4nMAssay Description:Inhibition of soyabean lipoxygenase-1 assessed as formation of 13-HPOD from linolenic acid preincubated for 10 mins measured by real-time spectrophot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed