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Found 80 with Last Name = 'wiscount' and Initial = 'cm'
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50280116(CHEMBL4177355)
Affinity DataIC50:  0.0120nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli using Val-Ser-Gln-Asn-(beta-naphtyl)Ala-Pro-Ile-Val as substrate preincubated for 30 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataIC50:  0.0130nMAssay Description:Inhibition of GAR transformylase from Lactobacillus caseiMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM13934(Atazanavir | BMS 232632 | CGP 73547 | CHEMBL1163 |...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM13934(Atazanavir | BMS 232632 | CGP 73547 | CHEMBL1163 |...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli using Val-Ser-Gln-Asn-(beta-naphtyl)Ala-Pro-Ile-Val as substrate preincubated for 30 mins f...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Sharp And Dohme Research Laboratories

LigandPNGBDBM842(Benzocycloalkyl Amines deriv. 12 | CHEMBL419923 | ...)
Affinity DataIC50:  0.100nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369371(CHEMBL1790750)
Affinity DataIC50:  0.123nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Sharp And Dohme Research Laboratories

LigandPNGBDBM1030(CHEMBL296115 | L-685,434 | Urethane deriv. 1 | ter...)
Affinity DataIC50:  0.300nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190623(CHEMBL3828743)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli using Val-Ser-Gln-Asn-(beta-naphtyl)Ala-Pro-Ile-Val as substrate preincubated for 30 mins f...More data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190623(CHEMBL3828743)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366557(CHEMBL1790748)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Sharp And Dohme Research Laboratories

LigandPNGBDBM841(Benzocycloalkyl Amines deriv. 11 | tert-butyl N-[(...)
Affinity DataIC50:  1.80nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Sharp And Dohme Research Laboratories

LigandPNGBDBM843(Benzocycloalkyl Amines deriv. 13 | tert-butyl N-[(...)
Affinity DataIC50:  1.90nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369364(CHEMBL1790760)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190624(CHEMBL3828417)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190625(CHEMBL3828552)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190638(CHEMBL3828119)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190631(CHEMBL3828166)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190639(CHEMBL3827524)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190629(CHEMBL3828678)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190636(CHEMBL3828275)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190641(CHEMBL3827205)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190640(CHEMBL3828355)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369370(CHEMBL1790745)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190642(CHEMBL3827353)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190627(CHEMBL3827958)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190626(CHEMBL3827319)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM3118(3,4-Dihydroquinazolinon 4l | 6-chloro-4-cyclopropy...)
Affinity DataIC50:  9.20nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190637(CHEMBL3827348)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190628(CHEMBL3827975)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50369371(CHEMBL1790750)
Affinity DataIC50:  10nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM3116(2-[2-(6-chloro-4-cyclopropyl-2-oxo-1,2,3,4-tetrahy...)
Affinity DataIC50:  10.8nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM3117(3,4-Dihydroquinazolinon 4k | 6-chloro-4-cyclopropy...)
Affinity DataIC50:  10.9nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190632(CHEMBL3827450)
Affinity DataIC50:  12nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM3115(3,4-Dihydroquinazolinon 4i | 6-chloro-4-cyclopropy...)
Affinity DataIC50:  12.8nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190630(CHEMBL3827960)
Affinity DataIC50:  14nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Sharp And Dohme Research Laboratories

LigandPNGBDBM836(Benzocycloalkyl Amines deriv. 6 | tert-butyl N-[(2...)
Affinity DataIC50:  16nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM3114(3,4-Dihydroquinazolinon 4h | 6-chloro-4-cyclopropy...)
Affinity DataIC50:  17.7nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Sharp And Dohme Research Laboratories

LigandPNGBDBM833(Benzocycloalkyl Amines deriv. 3 | Benzocycloalkyl ...)
Affinity DataIC50:  19nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM3106(3,4-Dihydroquinazolinon 4aa | 6-Chloro-4-cycloprop...)
Affinity DataIC50:  19.6nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50407296(CHEMBL2052018 | L-731735)
Affinity DataIC50:  20nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190633(CHEMBL3827407)
Affinity DataIC50:  20nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Sharp And Dohme Research Laboratories

LigandPNGBDBM835(Benzocycloalkyl Amines deriv. 5 | tert-butyl N-[(2...)
Affinity DataIC50:  21nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369368(CHEMBL1790744)
Affinity DataIC50:  21nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Sharp And Dohme Research Laboratories

LigandPNGBDBM837(Benzocycloalkyl Amines deriv. 7 | tert-butyl N-[(2...)
Affinity DataIC50:  22nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM3107(3,4-Dihydroquinazolinon 4a | 6-Chloro-4-cyclopyrop...)
Affinity DataIC50:  23.2nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369372(CHEMBL1790756)
Affinity DataIC50:  25nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369366(CHEMBL1790752)
Affinity DataIC50:  26nMAssay Description:Inhibition of bovine brain Farnesyltransferase at 1 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369375(CHEMBL1790753)
Affinity DataIC50:  27nMAssay Description:Inhibition of bovine brain Farnesyltransferase at 10 pMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck

Curated by ChEMBL
LigandPNGBDBM50190634(CHEMBL3828494)
Affinity DataIC50:  27nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369367(CHEMBL1790757)
Affinity DataIC50:  30nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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