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Found 4199 with Last Name = 'wright' and Initial = 'm'
TargetCoagulation factor X(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096105(2-(3-Carbamimidoyl-phenyl)-5-trifluoromethyl-2H-py...)
Affinity DataKi:  0.00100nMAssay Description:Binding affinity against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096099(2-(3-Carbamimidoyl-phenyl)-5-methyl-2H-pyrazole-3-...)
Affinity DataKi:  0.00500nMAssay Description:Binding affinity against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096101(2-(3-Carbamimidoyl-phenyl)-5-methyl-2H-pyrazole-3-...)
Affinity DataKi:  0.00700nMAssay Description:Binding affinity against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096110(2-(3-Carbamimidoyl-phenyl)-5-trifluoromethyl-2H-py...)
Affinity DataKi:  0.00800nMAssay Description:Binding affinity against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096091(2-(3-Carbamimidoyl-phenyl)-5-methyl-2H-pyrazole-3-...)
Affinity DataKi:  0.00800nMAssay Description:Binding affinity against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096085(2-(3-Carbamimidoyl-phenyl)-5-methyl-2H-pyrazole-3-...)
Affinity DataKi:  0.00900nMAssay Description:Binding affinity against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096108(2-(3-Carbamimidoyl-phenyl)-5-trifluoromethyl-2H-py...)
Affinity DataKi:  0.00900nMAssay Description:Binding affinity against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096098(2-(3-Carbamimidoyl-phenyl)-5-methyl-2H-pyrazole-3-...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
Dupont Pharmaceuticals

LigandPNGBDBM36648(3-alkylaminoindazole cyclic urea, (H))
Affinity DataKi: <0.0100nMpH: 5.5Assay Description:Protease inhibition fluorescence-based assay using cyclic ureas to inhibit HIV-protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
Dupont Pharmaceuticals

LigandPNGBDBM36647(3-Aminoindazole, 2)
Affinity DataKi:  0.0100nMpH: 5.5Assay Description:Protease inhibition fluorescence-based assay using cyclic ureas to inhibit HIV-protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591155(US11566003, Compound 111)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591146(US11566003, Compound 35)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591144((1R,2S,3R)-N-(8-amino-7-fluoro-6-(8-methyl-2,3-dih...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591252(2-((8-amino-7-fluoro-6-(4-methyl-6- (oxazol-2-yl)p...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12751(1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamo...)
Affinity DataKi:  0.0130nMAssay Description:Tested in vitro for inhibition of human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591250(2'-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-f...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591249(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591244((S)-2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12751(1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamo...)
Affinity DataKi:  0.0130nMAssay Description:Binding affinity against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591242(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591240(2-((8-amino-6-(5-amino-4- chloropyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591137(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7- f...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591137(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7- f...)
Affinity DataKi:  0.0130nMAssay Description:For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591211(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591217(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591220(2-((8-amino-6-(5-amino-4-ethylpyridin- 3-yl)-7-flu...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591222(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591225(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12751(1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamo...)
Affinity DataKi:  0.0130nM ΔG°:  -61.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were determined ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591143(1-(8-amino-7-fluoro-6-(8-methyl- 2,3-dihydro-1H-py...)
Affinity DataKi:  0.0140nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM160(3-{[(4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-3-{[3...)
Affinity DataKi:  0.0140nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591147(US11566003, Compound 36)
Affinity DataKi:  0.0140nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591246(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0150nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591136(2'-((8-amino-7-fluoro-6-(4- methylpyridin-3-yl)iso...)
Affinity DataKi:  0.0150nMAssay Description:For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096111(2-(3-Carbamimidoyl-phenyl)-5-trifluoromethyl-2H-py...)
Affinity DataKi:  0.0150nMAssay Description:Binding affinity against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591136(2'-((8-amino-7-fluoro-6-(4- methylpyridin-3-yl)iso...)
Affinity DataKi:  0.0150nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591177(2-((8-amino-6-(5-amino-4- chloropyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0160nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591139(US11566003, Compound 9)
Affinity DataKi:  0.0160nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591141(US11566003, Compound 11)
Affinity DataKi:  0.0160nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065080(3-[(4R,5S,6S,7R)-4,7-Dibenzyl-5,6-dihydroxy-3-(1H-...)
Affinity DataKi:  0.0160nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065075((4R,5S,6S,7R)-1-{3-[(1H-Benzoimidazol-2-ylmethyl)-...)
Affinity DataKi:  0.0160nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
Dupont Pharmaceuticals

LigandPNGBDBM36656(Cyclobutylmethyl cyclic urea)
Affinity DataKi:  0.0160nMpH: 5.5Assay Description:Protease inhibition fluorescence-based assay using cyclic ureas to inhibit HIV-protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591243((R)-2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-...)
Affinity DataKi:  0.0170nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591232(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0170nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591233(2-((8-amino-6-(5-amino-4,6- dimethylpyridin-3-yl)-...)
Affinity DataKi:  0.0170nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065089((4R,5R,6R)-Tetrahydro-1,3-bis[(3-benzamide oxime)-...)
Affinity DataKi:  0.0180nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065078((4R,5S,6S,7R)-1-(3-Amino-4-fluoro-benzyl)-4,7-dibe...)
Affinity DataKi:  0.0180nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
Dupont Pharmaceuticals

LigandPNGBDBM36649(3-alkylaminoindazole cyclic urea, (Me))
Affinity DataKi:  0.0180nMpH: 5.5Assay Description:Protease inhibition fluorescence-based assay using cyclic ureas to inhibit HIV-protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591167(2-((8-amino-7-fluoro-6-(8-methyl-2,3- dihydro-1H-p...)
Affinity DataKi:  0.0180nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHIV-1 protease(Human immunodeficiency virus)
Dupont Pharmaceuticals

LigandPNGBDBM161((4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(1...)
Affinity DataKi:  0.0180nMpH: 5.5Assay Description:Protease inhibition fluorescence-based assay using cyclic ureas to inhibit HIV-protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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