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Found 2541 with Last Name = 'yi' and Initial = 's'
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Affinity DataKi:  0.0140nMAssay Description:Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataKi:  0.0300nMAssay Description:Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Affinity DataKi:  0.0400nMAssay Description:Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50173652(2-(4-Hydroxy-phenyl)-1-[4-(2-piperidin-1-yl-ethoxy...)
Affinity DataKi:  0.190nMAssay Description:Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189257(CHEMBL378753 | NalBzOH)
Affinity DataKi:  0.200nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295066((2S)-8-Methyl-2-{[4-(6-nitroquinolin-2-yl)piperazi...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Cavia porcellus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189257(CHEMBL378753 | NalBzOH)
Affinity DataKi:  0.300nMAssay Description:Displacement of radiolabeled NalBzOH from kappa3 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50068133((4S,7S,13S)-13-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  0.300nMAssay Description:Displacement of radiolabeled DPDPE-Cl from delta opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Debrecen

Curated by ChEMBL
LigandPNGBDBM50010698((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]raclopride from dopamine D2 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189257(CHEMBL378753 | NalBzOH)
Affinity DataKi:  0.400nMAssay Description:Displacement of radiolabeled U69593 from kappa1 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Debrecen

Curated by ChEMBL
LigandPNGBDBM50016786((R)-2-Fluoro-6-methyl-5,6,6a,7-tetrahydro-4H-diben...)
Affinity DataKi:  0.430nMAssay Description:Displacement of [3H]raclopride from dopamine D2 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50173663(4-[5-Hydroxy-2-(4-hydroxy-phenyl)-3H-inden-1-yl]-b...)
Affinity DataKi:  0.460nMAssay Description:Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50173654(1-(4-Chloro-phenyl)-2-(4-hydroxy-phenyl)-3H-inden-...)
Affinity DataKi:  0.490nMAssay Description:Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189256(CHEMBL385048 | M3Pr6S)
Affinity DataKi:  0.600nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50173655(1-(4-Amino-phenyl)-2-(4-hydroxy-phenyl)-3H-inden-5...)
Affinity DataKi:  0.670nMAssay Description:Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50381677(CHEMBL1256748 | U-69593)
Affinity DataKi:  0.700nMAssay Description:Displacement of radiolabeled U69593 from kappa1 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189251(CHEMBL213228 | M3P6S)
Affinity DataKi:  0.700nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189252(CHEMBL214040 | M3A6S)
Affinity DataKi:  0.800nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295064((2S)-2-{[4-(6-Chloroquinolin-2-yl)piperazin-1-yl]m...)
Affinity DataKi:  0.880nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189247(CHEMBL1418 | M6S)
Affinity DataKi:  0.900nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM86708(CAS_146714-97-8 | CHEMBL31354 | CHEMBL514874 | CHE...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Harran University

Curated by ChEMBL
LigandPNGBDBM50157952(2-Morpholin-4-yl-N-(5-sulfamoyl-[1,3,4]thiadiazol-...)
Affinity DataKi:  0.900nMAssay Description:Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50173660(2-(4-Hydroxy-phenyl)-1-(4-trifluoromethyl-phenyl)-...)
Affinity DataKi:  0.910nMAssay Description:Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50160612(CHEMBL362823 | [2-(2,3-Dihydro-benzo[1,4]dioxin-5-...)
Affinity DataKi:  1.05nMAssay Description:Binding affinity determined against Serotonin transporter determined bydisplacement of [3H]-paroxetine from rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50160611(CHEMBL359549 | [4-(5-Fluoro-1H-indol-3-yl)-cyclohe...)
Affinity DataKi:  1.08nMAssay Description:Binding affinity determined against human 5-hydroxytryptamine 1A receptors transfected into CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50019056((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  1.10nMAssay Description:Displacement of radiolabeled DPDPE-Cl from delta opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295055(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  1.10nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]CP559440 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Debrecen

Curated by ChEMBL
LigandPNGBDBM50010697((R)-(-)-2-methoxyapomorphine | (R)-2-Methoxy-6-met...)
Affinity DataKi:  1.12nMAssay Description:Displacement of [3H]raclopride from dopamine D2 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50173659(1,2-Bis-(4-hydroxy-phenyl)-3H-inden-5-ol | CHEMBL2...)
Affinity DataKi:  1.30nMAssay Description:Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50173668(2-(4-Hydroxy-phenyl)-1-p-tolyl-3H-inden-5-ol | CHE...)
Affinity DataKi:  1.30nMAssay Description:Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189257(CHEMBL378753 | NalBzOH)
Affinity DataKi:  1.40nMAssay Description:Displacement of radiolabeled DPDPE-Cl from delta opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Debrecen

Curated by ChEMBL
LigandPNGBDBM50295863(CHEMBL562935 | N-Ethyl-2-(4-hydroxyphenyl)-norapom...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]raclopride from rat dopamine D2short receptor expressed in CHO-K1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189258(CHEMBL385448 | DM6S)
Affinity DataKi:  1.5nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295054((2S)-2-{[4-(6-Fluoroquinolin-2-yl)-1,4-diazepan-1-...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Harran University

Curated by ChEMBL
LigandPNGBDBM50157949(2-(4-Methyl-piperazin-1-yl)-N-(5-sulfamoyl-[1,3,4]...)
Affinity DataKi:  1.60nMAssay Description:Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50173652(2-(4-Hydroxy-phenyl)-1-[4-(2-piperidin-1-yl-ethoxy...)
Affinity DataKi:  1.70nMAssay Description:Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity towards human estrogen receptor beta in a competitive binding assay using fluorescently labelled estradiolMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50160611(CHEMBL359549 | [4-(5-Fluoro-1H-indol-3-yl)-cyclohe...)
Affinity DataKi:  1.73nMAssay Description:Binding affinity determined against Serotonin transporter determined bydisplacement of [3H]-paroxetine from rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
University Of Debrecen

Curated by ChEMBL
LigandPNGBDBM50251027((R)-(-)-2-(4-Hydroxyphenyl)-apomorphine hydrochlor...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]spiperone from rat recombinant dopamine D3 receptor expressed in SF9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Harran University

Curated by ChEMBL
LigandPNGBDBM50157958(2-(4-Benzyl-piperazin-1-yl)-N-(5-sulfamoyl-[1,3,4]...)
Affinity DataKi:  1.80nMAssay Description:Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50208974(CHEMBL390543 | N-cyclohexyl-2-(2,4-dichlorophenyl)...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]CP559440 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Harran University

Curated by ChEMBL
LigandPNGBDBM50157950(3-(4-Methyl-piperazin-1-yl)-N-(5-sulfamoyl-[1,3,4]...)
Affinity DataKi:  1.90nMAssay Description:Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295055(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Debrecen

Curated by ChEMBL
LigandPNGBDBM50295866(CHEMBL560721 | N-Propyl-2-(4-hydroxyphenyl)-norapo...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]raclopride from rat dopamine D2short receptor expressed in CHO-K1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50173660(2-(4-Hydroxy-phenyl)-1-(4-trifluoromethyl-phenyl)-...)
Affinity DataKi:  2.10nMAssay Description:Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50173655(1-(4-Amino-phenyl)-2-(4-hydroxy-phenyl)-3H-inden-5...)
Affinity DataKi:  2.20nMAssay Description:Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50208948(2-(2-chlorophenyl)-1-(4-chlorophenyl)-N-cyclohexyl...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]CP559440 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295053((S)-2-((4-(1H-Indol-3-yl)-5,6-dihydropyridin-1(2H)...)
Affinity DataKi:  2.34nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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