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Found 3327 with Last Name = 'zhao' and Initial = 'k'
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
New York University

Curated by ChEMBL
LigandPNGBDBM50086645([4-(4-hydroxybenzyl)phenoxy]methylphosphonate)
Affinity DataKi:  4.70E+4nMAssay Description:Compound was evaluated for the inhibition constant against Protein-tyrosine phosphatase (PTP1B )More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNADP-dependent malic enzyme(Escherichia coli (strain K12))
Institute Of Chemical Physics

Curated by ChEMBL
LigandPNGBDBM50338502(5-O-phosphate-1-N-(4'-(4''-methoxyhenyl))-[1',2',3...)
Affinity DataKi:  5.70E+4nMAssay Description:Inhibition of Escherichia coli K-12 recombinant NAD-dependent malic enzyme by Dixon plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
New York University

Curated by ChEMBL
LigandPNGBDBM50086647(hydrogen (1-phenanthryloxy)methylphosphonate)
Affinity DataKi:  4.10E+5nMAssay Description:Compound was evaluated for the inhibition constant against Protein-tyrosine phosphatase (PTP1B )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
New York University

Curated by ChEMBL
LigandPNGBDBM50086647(hydrogen (1-phenanthryloxy)methylphosphonate)
Affinity DataKi:  5.70E+5nMAssay Description:Compound was evaluated for the inhibition constant against dual specificity phosphatase VHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
New York University

Curated by ChEMBL
LigandPNGBDBM50086644([4-(carboxymethyl)phenoxy]methylphosphonate)
Affinity DataKi:  1.10E+6nMAssay Description:Compound was evaluated for the inhibition constant against Protein-tyrosine phosphatase (PTP1B )More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
New York University

Curated by ChEMBL
LigandPNGBDBM50086646(hydrogen (2-naphthyloxy)methylphosphonate)
Affinity DataKi:  1.30E+6nMAssay Description:Compound was evaluated for the inhibition constant against Protein-tyrosine phosphatase (PTP1B )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
New York University

Curated by ChEMBL
LigandPNGBDBM50086645([4-(4-hydroxybenzyl)phenoxy]methylphosphonate)
Affinity DataKi:  1.30E+6nMAssay Description:Compound was evaluated for the inhibition constant against dual specificity phosphatase VHRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
New York University

Curated by ChEMBL
LigandPNGBDBM50086649(hydrogen (1-naphthyloxy)methylphosphonate)
Affinity DataKi:  1.30E+6nMAssay Description:Compound was evaluated for the inhibition constant against Protein-tyrosine phosphatase (PTP1B )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
New York University

Curated by ChEMBL
LigandPNGBDBM50086644([4-(carboxymethyl)phenoxy]methylphosphonate)
Affinity DataKi:  2.60E+6nMAssay Description:Compound was evaluated for the inhibition constant against dual specificity phosphatase VHRMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
New York University

Curated by ChEMBL
LigandPNGBDBM50086648(phenoxymethylphosphonate)
Affinity DataKi:  3.30E+6nMAssay Description:Compound was evaluated for the inhibition constant against Protein-tyrosine phosphatase (PTP1B )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
New York University

Curated by ChEMBL
LigandPNGBDBM50086649(hydrogen (1-naphthyloxy)methylphosphonate)
Affinity DataKi:  4.80E+6nMAssay Description:Compound was evaluated for the inhibition constant against dual specificity phosphatase VHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
New York University

Curated by ChEMBL
LigandPNGBDBM50086646(hydrogen (2-naphthyloxy)methylphosphonate)
Affinity DataKi:  5.70E+6nMAssay Description:Compound was evaluated for the inhibition constant against dual specificity phosphatase VHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
New York University

Curated by ChEMBL
LigandPNGBDBM50086648(phenoxymethylphosphonate)
Affinity DataKi:  2.60E+7nMAssay Description:Compound was evaluated for the inhibition constant against dual specificity phosphatase VHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245474(US9428503, 1)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs by HTRF as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM451065(US10676479, Example 95 | ethyl 5-(((5-fluoro-2,3-d...)
Affinity DataIC50: <0.100nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM451038(8-(4-((dimethylamino)methyl)phenyl)-N-(2-fluoro- |...)
Affinity DataIC50: <0.100nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245500(US9428503, 28)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245505(US9428503, 33)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245478(US9428503, 5)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245514(US9428503, 42)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245475(US9428503, 2)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245510(US9428503, 38)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245490(US9428503, 17)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245474(US9428503, 1)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM451070(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)- |...)
Affinity DataIC50:  0.600nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM451062(US10676479, Example 92 | ethyl 5-(((5-fluoro-2,3-d...)
Affinity DataIC50:  0.700nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245491(US9428503, 18)
Affinity DataIC50:  0.760nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245481(US9428503, 8)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM291686(8-(1,3-Dimethyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3-...)
Affinity DataIC50:  0.900nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291686(8-(1,3-Dimethyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3-...)
Affinity DataIC50:  0.900nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245489(US9428503, 16)
Affinity DataIC50:  0.940nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291695(3-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl...)
Affinity DataIC50:  1nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Jiangnan University

Curated by ChEMBL
LigandPNGBDBM31539(pyrazolo[4,3-h]quinazoline-3-carboxamide, 22)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK2/Cyclin A2 (unknown origin) using FAM-labeled peptide as substrate after 40 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM291695(3-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl...)
Affinity DataIC50:  1nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245479(US9428503, 6)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245519(US9428503, 47)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245525(US9428503, 53)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM291815((5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methy...)
Affinity DataIC50:  1.30nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291815((5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methy...)
Affinity DataIC50:  1.30nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM291908(8-(6-((dimethylamino)methyl)-2-methylpyridin-3-yl)...)
Affinity DataIC50:  1.40nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM291925(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  1.40nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291925(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  1.40nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291908(8-(6-((dimethylamino)methyl)-2-methylpyridin-3-yl)...)
Affinity DataIC50:  1.40nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245477(US9428503, 4)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM291909(8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...)
Affinity DataIC50:  1.5nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291909(8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...)
Affinity DataIC50:  1.5nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM291824(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  1.60nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291824(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  1.60nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291824(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  1.70nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50378199(CHEMBL4163629)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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