TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
New York University
Curated by ChEMBL
New York University
Curated by ChEMBL
Affinity DataKi: 4.70E+4nMAssay Description:Compound was evaluated for the inhibition constant against Protein-tyrosine phosphatase (PTP1B )More data for this Ligand-Target Pair
TargetNADP-dependent malic enzyme(Escherichia coli (strain K12))
Institute Of Chemical Physics
Curated by ChEMBL
Institute Of Chemical Physics
Curated by ChEMBL
Affinity DataKi: 5.70E+4nMAssay Description:Inhibition of Escherichia coli K-12 recombinant NAD-dependent malic enzyme by Dixon plotMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
New York University
Curated by ChEMBL
New York University
Curated by ChEMBL
Affinity DataKi: 4.10E+5nMAssay Description:Compound was evaluated for the inhibition constant against Protein-tyrosine phosphatase (PTP1B )More data for this Ligand-Target Pair
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
New York University
Curated by ChEMBL
New York University
Curated by ChEMBL
Affinity DataKi: 5.70E+5nMAssay Description:Compound was evaluated for the inhibition constant against dual specificity phosphatase VHRMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
New York University
Curated by ChEMBL
New York University
Curated by ChEMBL
Affinity DataKi: 1.10E+6nMAssay Description:Compound was evaluated for the inhibition constant against Protein-tyrosine phosphatase (PTP1B )More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
New York University
Curated by ChEMBL
New York University
Curated by ChEMBL
Affinity DataKi: 1.30E+6nMAssay Description:Compound was evaluated for the inhibition constant against Protein-tyrosine phosphatase (PTP1B )More data for this Ligand-Target Pair
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
New York University
Curated by ChEMBL
New York University
Curated by ChEMBL
Affinity DataKi: 1.30E+6nMAssay Description:Compound was evaluated for the inhibition constant against dual specificity phosphatase VHRMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
New York University
Curated by ChEMBL
New York University
Curated by ChEMBL
Affinity DataKi: 1.30E+6nMAssay Description:Compound was evaluated for the inhibition constant against Protein-tyrosine phosphatase (PTP1B )More data for this Ligand-Target Pair
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
New York University
Curated by ChEMBL
New York University
Curated by ChEMBL
Affinity DataKi: 2.60E+6nMAssay Description:Compound was evaluated for the inhibition constant against dual specificity phosphatase VHRMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
New York University
Curated by ChEMBL
New York University
Curated by ChEMBL
Affinity DataKi: 3.30E+6nMAssay Description:Compound was evaluated for the inhibition constant against Protein-tyrosine phosphatase (PTP1B )More data for this Ligand-Target Pair
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
New York University
Curated by ChEMBL
New York University
Curated by ChEMBL
Affinity DataKi: 4.80E+6nMAssay Description:Compound was evaluated for the inhibition constant against dual specificity phosphatase VHRMore data for this Ligand-Target Pair
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
New York University
Curated by ChEMBL
New York University
Curated by ChEMBL
Affinity DataKi: 5.70E+6nMAssay Description:Compound was evaluated for the inhibition constant against dual specificity phosphatase VHRMore data for this Ligand-Target Pair
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
New York University
Curated by ChEMBL
New York University
Curated by ChEMBL
Affinity DataKi: 2.60E+7nMAssay Description:Compound was evaluated for the inhibition constant against dual specificity phosphatase VHRMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs by HTRF as...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: <0.100nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: <0.100nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
Affinity DataIC50: 0.170nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Affinity DataIC50: 0.570nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 0.600nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 0.700nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
Affinity DataIC50: 0.760nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Affinity DataIC50: 0.780nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 0.900nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.940nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK2/Cyclin A2 (unknown origin) using FAM-labeled peptide as substrate after 40 minsMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 1nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 1.30nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 1.40nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 1.40nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 1.5nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 1.60nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair