Found 2807 with Last Name = 'zhou' and Initial = 'm' TargetMineralocorticoid receptor(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Curated by ChEMBL
Affinity DataKi: 0.0800nMAssay Description:Displacement of [3H]-Aldosterone from MR overexpressed in human 293 cells measured after 2 hrs by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.140nMAssay Description:Inhibition of human factor 10a using acromogenic substrate S-2222 preincubated for 30 mins before substrate addition measured after 20 mins by spectr...More data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Curated by ChEMBL
Affinity DataKi: 0.230nMAssay Description:Displacement of [3H]-Aldosterone from MR overexpressed in human 293 cells measured after 2 hrs by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Curated by ChEMBL
Affinity DataKi: 0.330nMAssay Description:Displacement of [3H]-Aldosterone from MR overexpressed in human 293 cells measured after 2 hrs by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Displacement of [3H]-Aldosterone from MR overexpressed in human 293 cells measured after 2 hrs by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Curated by ChEMBL
Affinity DataKi: 0.790nMAssay Description:Displacement of [3H]-Aldosterone from MR overexpressed in human 293 cells measured after 2 hrs by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataKi: <1nMAssay Description:Binding affinity to full length human MCL1 expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant preincubated for 30 mins followed...More data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Binding affinity to full length human Bcl-2 expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant preincubated for 30 mins followe...More data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Binding affinity to full length human Bcl-xl expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant preincubated for 30 mins follow...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataKi: <1nMAssay Description:Inhibition of FITC-labeled BH3 peptide binding to human MCL1 expressed in Escherichia coli BL21 (DE3) incubated for 0.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataKi: <1.20nMAssay Description:Binding affinity to full length human MCL1 (173 to 321 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant incubated f...More data for this Ligand-Target Pair
Affinity DataKi: 6.90nM ΔG°: -48.5kJ/molepH: 7.5 T: 2°CAssay Description:A radioactive assay was used for the enzyme kinetics in the presence of EM1404 at different concentrations for its Ki determination. Reactions were i...More data for this Ligand-Target Pair
3D Structure (crystal)TargetMineralocorticoid receptor(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Curated by ChEMBL
Affinity DataKi: 9nMAssay Description:Compound was tested for its ability to stimulate [35S]GTP-gamma-S, binding to membranes from C6 glioma cells stably expressing rat mu opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Displacement of [3H]-cortisol from MR overexpressed in human 293 cells measured after 2 hrs by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 35nMAssay Description:Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 39nMAssay Description:Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 45nMAssay Description:Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 49nMAssay Description:Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 73nMAssay Description:Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 85nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
Affinity DataKi: 90nMAssay Description:Inhibition of human factor 10a using acromogenic substrate S-2222 preincubated for 30 mins before substrate addition measured after 20 mins by spectr...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD3 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 140nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD3 BrD2 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 150nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 151nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 170nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 170nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
Affinity DataKi: 180nMAssay Description:Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataKi: 180nMAssay Description:Displacement of fluorescent-labeled BID-BH3 peptide from MCL1 (unknown origin) incubated for 2 hrs by fluorescence polarization-based competitive bin...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 220nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD3 BrD2 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 240nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD3 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 290nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD3 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
Affinity DataKi: 310nMAssay Description:Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 310nMAssay Description:Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 320nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD3 BrD2 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataKi: 320nMAssay Description:Binding affinity to full length human MCL1 expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant preincubated for 30 mins followed...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 320nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 340nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD2 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataKi: 360nMAssay Description:Binding affinity to full length human MCL1 expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant preincubated for 30 mins followed...More data for this Ligand-Target Pair
Affinity DataKi: 360nMAssay Description:Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataKi: 360nMAssay Description:Binding affinity to full length human MCL1 expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant preincubated for 30 mins followed...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataKi: 370nMAssay Description:Binding affinity to full length human MCL1 expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant preincubated for 30 mins followed...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataKi: 420nMAssay Description:Binding affinity to full length human MCL1 expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant preincubated for 30 mins followed...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 440nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD2 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataKi: 490nMAssay Description:Binding affinity to full length human MCL1 expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant preincubated for 30 mins followed...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataKi: 490nMAssay Description:Displacement of fluorescent-labeled BID-BH3 peptide from MCL1 (unknown origin) incubated for 2 hrs by fluorescence polarization-based competitive bin...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 500nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
