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15 similar compounds to monomer 50300690

Compile data set for download or QSAR
Wt: 576.6
BDBM103622
Wt: 592.6
BDBM103623
Wt: 431.5
BDBM50300692
Wt: 447.5
BDBM50300693
Purchase
Wt: 529.6
BDBM50300694
Wt: 558.6
BDBM50300695
Wt: 574.6
BDBM50300696
Wt: 587.7
BDBM50300697
Wt: 651.7
BDBM50300698
Wt: 560.6
BDBM50300699
Wt: 560.6
BDBM50300700
Purchase
Wt: 475.5
BDBM50300701
Wt: 503.5
BDBM50300702
Wt: 572.6
BDBM50300705
Wt: 558.6
BDBM50300706

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 103622,103623,50300692,50300693,50300694,50300695,50300696,50300697,50300698,50300699,50300700,50300701,50300702,50300705,50300706   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM103622
PNG
(US8551963, I-1)
Show SMILES CC(C)(CO)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C29H32N6O5S/c1-29(2,18-36)25-16-26(33-40-25)32-27(37)30-20-5-3-19(4-6-20)22-17-35-23-8-7-21(15-24(23)41-28(35)31-22)39-14-11-34-9-12-38-13-10-34/h3-8,15-17,36H,9-14,18H2,1-2H3,(H2,30,32,33,37)
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US Patent
n/an/an/a 0.680n/an/an/an/an/a



Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.


US Patent US8551963 (2013)


BindingDB Entry DOI: 10.7270/Q23F4N7J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50300706
PNG
(CHEMBL584293 | N-(5-tert-Butylisoxazol-3-yl)-N'-{4...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(CCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C30H34N6O3S/c1-30(2,3)26-18-27(34-39-26)33-28(37)31-22-9-7-21(8-10-22)23-19-36-24-11-6-20(17-25(24)40-29(36)32-23)5-4-12-35-13-15-38-16-14-35/h6-11,17-19H,4-5,12-16H2,1-3H3,(H2,31,33,34,37)
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n/an/an/a 1.30n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay


J Med Chem 52: 7808-16 (2009)


Article DOI: 10.1021/jm9007533
BindingDB Entry DOI: 10.7270/Q2319VZ6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM103622
PNG
(US8551963, I-1)
Show SMILES CC(C)(CO)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C29H32N6O5S/c1-29(2,18-36)25-16-26(33-40-25)32-27(37)30-20-5-3-19(4-6-20)22-17-35-23-8-7-21(15-24(23)41-28(35)31-22)39-14-11-34-9-12-38-13-10-34/h3-8,15-17,36H,9-14,18H2,1-2H3,(H2,30,32,33,37)
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n/an/an/a 5.5n/an/an/an/an/a



Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.


US Patent US8551963 (2013)


BindingDB Entry DOI: 10.7270/Q23F4N7J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM103622
PNG
(US8551963, I-1)
Show SMILES CC(C)(CO)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C29H32N6O5S/c1-29(2,18-36)25-16-26(33-40-25)32-27(37)30-20-5-3-19(4-6-20)22-17-35-23-8-7-21(15-24(23)41-28(35)31-22)39-14-11-34-9-12-38-13-10-34/h3-8,15-17,36H,9-14,18H2,1-2H3,(H2,30,32,33,37)
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n/an/an/a 0.690n/an/an/an/an/a



Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.


US Patent US8551963 (2013)


BindingDB Entry DOI: 10.7270/Q23F4N7J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM103622
PNG
(US8551963, I-1)
Show SMILES CC(C)(CO)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C29H32N6O5S/c1-29(2,18-36)25-16-26(33-40-25)32-27(37)30-20-5-3-19(4-6-20)22-17-35-23-8-7-21(15-24(23)41-28(35)31-22)39-14-11-34-9-12-38-13-10-34/h3-8,15-17,36H,9-14,18H2,1-2H3,(H2,30,32,33,37)
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n/an/an/a 0.770n/an/an/an/an/a



Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.


US Patent US8551963 (2013)


BindingDB Entry DOI: 10.7270/Q23F4N7J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM103623
PNG
(US8551963, 1a)
Show SMILES CC(CO)(CO)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C29H32N6O6S/c1-29(17-36,18-37)25-15-26(33-41-25)32-27(38)30-20-4-2-19(3-5-20)22-16-35-23-7-6-21(14-24(23)42-28(35)31-22)40-13-10-34-8-11-39-12-9-34/h2-7,14-16,36-37H,8-13,17-18H2,1H3,(H2,30,32,33,38)
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n/an/an/a 1.60n/an/an/an/an/a



Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.


US Patent US8551963 (2013)


BindingDB Entry DOI: 10.7270/Q23F4N7J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM103623
PNG
(US8551963, 1a)
Show SMILES CC(CO)(CO)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C29H32N6O6S/c1-29(17-36,18-37)25-15-26(33-41-25)32-27(38)30-20-4-2-19(3-5-20)22-16-35-23-7-6-21(14-24(23)42-28(35)31-22)40-13-10-34-8-11-39-12-9-34/h2-7,14-16,36-37H,8-13,17-18H2,1H3,(H2,30,32,33,38)
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n/an/an/a 3.70n/an/an/an/an/a



Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.


US Patent US8551963 (2013)


BindingDB Entry DOI: 10.7270/Q23F4N7J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM103623
PNG
(US8551963, 1a)
Show SMILES CC(CO)(CO)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C29H32N6O6S/c1-29(17-36,18-37)25-15-26(33-41-25)32-27(38)30-20-4-2-19(3-5-20)22-16-35-23-7-6-21(14-24(23)42-28(35)31-22)40-13-10-34-8-11-39-12-9-34/h2-7,14-16,36-37H,8-13,17-18H2,1H3,(H2,30,32,33,38)
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n/an/an/a 7.10n/an/an/an/an/a



Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.


US Patent US8551963 (2013)


BindingDB Entry DOI: 10.7270/Q23F4N7J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM103623
PNG
(US8551963, 1a)
Show SMILES CC(CO)(CO)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C29H32N6O6S/c1-29(17-36,18-37)25-15-26(33-41-25)32-27(38)30-20-4-2-19(3-5-20)22-16-35-23-7-6-21(14-24(23)42-28(35)31-22)40-13-10-34-8-11-39-12-9-34/h2-7,14-16,36-37H,8-13,17-18H2,1H3,(H2,30,32,33,38)
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n/an/an/a 2.20n/an/an/an/an/a



Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.


US Patent US8551963 (2013)


BindingDB Entry DOI: 10.7270/Q23F4N7J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM103623
PNG
(US8551963, 1a)
Show SMILES CC(CO)(CO)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C29H32N6O6S/c1-29(17-36,18-37)25-15-26(33-41-25)32-27(38)30-20-4-2-19(3-5-20)22-16-35-23-7-6-21(14-24(23)42-28(35)31-22)40-13-10-34-8-11-39-12-9-34/h2-7,14-16,36-37H,8-13,17-18H2,1H3,(H2,30,32,33,38)
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n/an/an/a 4.10n/an/an/an/an/a



Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.


US Patent US8551963 (2013)


BindingDB Entry DOI: 10.7270/Q23F4N7J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50300692
PNG
(CHEMBL578024 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-[...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2ccccc32)no1
Show InChI InChI=1S/C23H21N5O2S/c1-23(2,3)19-12-20(27-30-19)26-21(29)24-15-10-8-14(9-11-15)16-13-28-17-6-4-5-7-18(17)31-22(28)25-16/h4-13H,1-3H3,(H2,24,26,27,29)
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n/an/an/a 1.90n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay


J Med Chem 52: 7808-16 (2009)


Article DOI: 10.1021/jm9007533
BindingDB Entry DOI: 10.7270/Q2319VZ6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50300693
PNG
(CHEMBL575307 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-[...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(O)ccc32)no1
Show InChI InChI=1S/C23H21N5O3S/c1-23(2,3)19-11-20(27-31-19)26-21(30)24-14-6-4-13(5-7-14)16-12-28-17-9-8-15(29)10-18(17)32-22(28)25-16/h4-12,29H,1-3H3,(H2,24,26,27,30)
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n/an/an/a 2.70n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay


J Med Chem 52: 7808-16 (2009)


Article DOI: 10.1021/jm9007533
BindingDB Entry DOI: 10.7270/Q2319VZ6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50300694
PNG
(CHEMBL575312 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Show SMILES CN1CCN(CC1)c1ccc2c(c1)sc1nc(cn21)-c1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1
Show InChI InChI=1S/C28H31N7O2S/c1-28(2,3)24-16-25(32-37-24)31-26(36)29-19-7-5-18(6-8-19)21-17-35-22-10-9-20(15-23(22)38-27(35)30-21)34-13-11-33(4)12-14-34/h5-10,15-17H,11-14H2,1-4H3,(H2,29,31,32,36)
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n/an/an/a 1.20n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay


J Med Chem 52: 7808-16 (2009)


Article DOI: 10.1021/jm9007533
BindingDB Entry DOI: 10.7270/Q2319VZ6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50300695
PNG
(CHEMBL575269 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCCCC4)ccc32)no1
Show InChI InChI=1S/C30H34N6O3S/c1-30(2,3)26-18-27(34-39-26)33-28(37)31-21-9-7-20(8-10-21)23-19-36-24-12-11-22(17-25(24)40-29(36)32-23)38-16-15-35-13-5-4-6-14-35/h7-12,17-19H,4-6,13-16H2,1-3H3,(H2,31,33,34,37)
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n/an/an/a 1.5n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay


J Med Chem 52: 7808-16 (2009)


Article DOI: 10.1021/jm9007533
BindingDB Entry DOI: 10.7270/Q2319VZ6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50300696
PNG
(CHEMBL574349 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C30H34N6O4S/c1-30(2,3)26-18-27(34-40-26)33-28(37)31-21-7-5-20(6-8-21)23-19-36-24-10-9-22(17-25(24)41-29(36)32-23)39-14-4-11-35-12-15-38-16-13-35/h5-10,17-19H,4,11-16H2,1-3H3,(H2,31,33,34,37)
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n/an/an/a 0.990n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay


J Med Chem 52: 7808-16 (2009)


Article DOI: 10.1021/jm9007533
BindingDB Entry DOI: 10.7270/Q2319VZ6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50300697
PNG
(CHEMBL574039 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-(...)
Show SMILES CN1CCN(CCCOc2ccc3c(c2)sc2nc(cn32)-c2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)CC1
Show InChI InChI=1S/C31H37N7O3S/c1-31(2,3)27-19-28(35-41-27)34-29(39)32-22-8-6-21(7-9-22)24-20-38-25-11-10-23(18-26(25)42-30(38)33-24)40-17-5-12-37-15-13-36(4)14-16-37/h6-11,18-20H,5,12-17H2,1-4H3,(H2,32,34,35,39)
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n/an/an/a 1.70n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay


J Med Chem 52: 7808-16 (2009)


Article DOI: 10.1021/jm9007533
BindingDB Entry DOI: 10.7270/Q2319VZ6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50300698
PNG
(CHEMBL585002 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-(...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCCN4CCN(CC4)S(C)(=O)=O)ccc32)no1
Show InChI InChI=1S/C31H37N7O5S2/c1-31(2,3)27-19-28(35-43-27)34-29(39)32-22-8-6-21(7-9-22)24-20-38-25-11-10-23(18-26(25)44-30(38)33-24)42-17-5-12-36-13-15-37(16-14-36)45(4,40)41/h6-11,18-20H,5,12-17H2,1-4H3,(H2,32,34,35,39)
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n/an/an/a 9.70n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay


J Med Chem 52: 7808-16 (2009)


Article DOI: 10.1021/jm9007533
BindingDB Entry DOI: 10.7270/Q2319VZ6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50300699
PNG
(CHEMBL577406 | N-(5-tert-Butylisoxazol-3-yl)-N'-{4...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cccc(OCCN4CCOCC4)c32)no1
Show InChI InChI=1S/C29H32N6O4S/c1-29(2,3)24-17-25(33-39-24)32-27(36)30-20-9-7-19(8-10-20)21-18-35-26-22(5-4-6-23(26)40-28(35)31-21)38-16-13-34-11-14-37-15-12-34/h4-10,17-18H,11-16H2,1-3H3,(H2,30,32,33,36)
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n/an/an/a 5.20n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay


J Med Chem 52: 7808-16 (2009)


Article DOI: 10.1021/jm9007533
BindingDB Entry DOI: 10.7270/Q2319VZ6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50300700
PNG
(CHEMBL567839 | N-(5-tert-Butylisoxazol-3-yl)-N'-{4...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2ccc(OCCN4CCOCC4)cc32)no1
Show InChI InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-16-21(8-9-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
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n/an/an/a 2.30n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay


J Med Chem 52: 7808-16 (2009)


Article DOI: 10.1021/jm9007533
BindingDB Entry DOI: 10.7270/Q2319VZ6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50300701
PNG
(2-{4-[3-(5-tert-Butyl-isoxazol-3-yl)ureido]phenyl}...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(ccc32)C(O)=O)no1
Show InChI InChI=1S/C24H21N5O4S/c1-24(2,3)19-11-20(28-33-19)27-22(32)25-15-7-4-13(5-8-15)16-12-29-17-9-6-14(21(30)31)10-18(17)34-23(29)26-16/h4-12H,1-3H3,(H,30,31)(H2,25,27,28,32)
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n/an/an/a 1.60n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay


J Med Chem 52: 7808-16 (2009)


Article DOI: 10.1021/jm9007533
BindingDB Entry DOI: 10.7270/Q2319VZ6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50300702
PNG
(3-(2-{4-[3-(5-tert-Butyl-isoxazol-3-yl)ureido]phen...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(CCC(O)=O)ccc32)no1
Show InChI InChI=1S/C26H25N5O4S/c1-26(2,3)21-13-22(30-35-21)29-24(34)27-17-8-6-16(7-9-17)18-14-31-19-10-4-15(5-11-23(32)33)12-20(19)36-25(31)28-18/h4,6-10,12-14H,5,11H2,1-3H3,(H,32,33)(H2,27,29,30,34)
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n/an/an/a 1.30n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay


J Med Chem 52: 7808-16 (2009)


Article DOI: 10.1021/jm9007533
BindingDB Entry DOI: 10.7270/Q2319VZ6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50300705
PNG
(CHEMBL574526 | N-(5-tert-Butylisoxazol-3-yl)-N'-{4...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(CCC(=O)N4CCOCC4)ccc32)no1
Show InChI InChI=1S/C30H32N6O4S/c1-30(2,3)25-17-26(34-40-25)33-28(38)31-21-8-6-20(7-9-21)22-18-36-23-10-4-19(16-24(23)41-29(36)32-22)5-11-27(37)35-12-14-39-15-13-35/h4,6-10,16-18H,5,11-15H2,1-3H3,(H2,31,33,34,38)
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n/an/an/a 1.5n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay


J Med Chem 52: 7808-16 (2009)


Article DOI: 10.1021/jm9007533
BindingDB Entry DOI: 10.7270/Q2319VZ6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM103622
PNG
(US8551963, I-1)
Show SMILES CC(C)(CO)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C29H32N6O5S/c1-29(2,18-36)25-16-26(33-40-25)32-27(37)30-20-5-3-19(4-6-20)22-17-35-23-8-7-21(15-24(23)41-28(35)31-22)39-14-11-34-9-12-38-13-10-34/h3-8,15-17,36H,9-14,18H2,1-2H3,(H2,30,32,33,37)
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US Patent
n/an/an/a 1.90n/an/an/an/an/a



Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.


US Patent US8551963 (2013)


BindingDB Entry DOI: 10.7270/Q23F4N7J
More data for this
Ligand-Target Pair