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11 similar compounds to monomer 50104412

Wt: 161.1
BDBM108419
Wt: 147.1
BDBM50075408
Wt: 147.1
BDBM50182801
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Wt: 147.1
BDBM50263043
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Wt: 187.2
BDBM50288853
Wt: 147.1
BDBM50350756
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Wt: 147.1
BDBM50350757
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Wt: 147.1
BDBM50350758
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Wt: 147.1
BDBM50350759
Wt: 147.1
BDBM50350761
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Wt: 147.1
BDBM50350762
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 54 hits for monomerid = 108419,50075408,50182801,50263043,50288853,50350756,50350757,50350758,50350759,50350761,50350762   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50075408
PNG
(5-(hydroxymethyl)piperidine-3,4-diol | CHEMBL34512...)
Show SMILES OCC1CNCC(O)C1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2
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5n/an/an/an/an/an/a7.0n/a



University of British Columbia



Assay Description
Fluorescene-based assay using beta-glucocerebrosidase.


Chembiochem 12: 2151-4 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-glucosidase


(Agrobacterium tumefaciens)
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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7n/an/an/an/an/an/an/an/a



Technische Universität Graz

Curated by ChEMBL


Assay Description
Inhibition of Agrobacterium sp. beta-glucosidase


Bioorg Med Chem Lett 16: 2067-70 (2006)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM108419
PNG
(US8604206, 10 | US8604206, 9)
Show SMILES CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1
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10n/a 20n/an/an/an/a7.0n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


Citation and Details
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50075408
PNG
(5-(hydroxymethyl)piperidine-3,4-diol | CHEMBL34512...)
Show SMILES OCC1CNCC(O)C1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2
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23n/an/an/an/an/an/a5.5n/a



University of British Columbia



Assay Description
Fluorescene-based assay using beta-glucocerebrosidase.


Chembiochem 12: 2151-4 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-galactosidase


(Escherichia coli)
BDBM50350758
PNG
(CHEMBL1818433)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6+/m1/s1
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31n/an/an/an/an/an/an/an/a



Graz University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli lacZ beta-galactosidase using 4-nitrophenyl-beta-D-galactopyranoside as substrate preincubated up to 5 mins followed b...


Citation and Details
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM108419
PNG
(US8604206, 10 | US8604206, 9)
Show SMILES CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1
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35n/a 66n/an/an/an/a7.0n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


Citation and Details
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM108419
PNG
(US8604206, 10 | US8604206, 9)
Show SMILES CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1
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44n/a 107n/an/an/an/a5.2n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


Citation and Details
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50075408
PNG
(5-(hydroxymethyl)piperidine-3,4-diol | CHEMBL34512...)
Show SMILES OCC1CNCC(O)C1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2
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110n/an/an/an/an/an/an/an/a



Technische Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibitory activity against beta-glucosidase of sweet almond


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM108419
PNG
(US8604206, 10 | US8604206, 9)
Show SMILES CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1
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142n/a 343n/an/an/an/a5.2n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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5.20E+3n/an/an/an/an/an/an/an/a



The National Hellenic Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of non-phosphorylated form of rabbit muscle glycogen phosphorylase in presence of phosphate


J Med Chem 49: 5687-701 (2006)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-galactosidase


(Bos taurus (Bovine))
BDBM50350758
PNG
(CHEMBL1818433)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6+/m1/s1
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1.00E+4n/an/an/an/an/an/an/an/a



Graz University of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-galactosidase using 4-nitrophenyl-beta-D-galactopyranoside as substrate preincubated up to 5 mins followed by substra...


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Homo sapiens)
BDBM50075408
PNG
(5-(hydroxymethyl)piperidine-3,4-diol | CHEMBL34512...)
Show SMILES OCC1CNCC(O)C1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2
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8.60E+4n/an/an/an/an/an/an/an/a



Technische Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibitory activity against alpha-glucosidase of yeast


Citation and Details
More data for this
Ligand-Target Pair
Trehalose Synthase (TreS)


(Mycobacterium tuberculosis)
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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1.40E+5n/an/an/an/an/an/an/an/a



University of British Columbia



Assay Description
The inhibition of TreS by a range of known alpha-glucosidase inhibitor was assayed.


J Biol Chem 286: 35601-9 (2011)

More data for this
Ligand-Target Pair
Alpha-galactosidase A


(Homo sapiens (Human))
BDBM50350758
PNG
(CHEMBL1818433)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6+/m1/s1
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>2.00E+6n/an/an/an/an/an/an/an/a



Graz University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant lysosomal alpha-galactosidase using 2,4-dinitrophenyl-alpha-D-galactopyranoside as substrate preincubated up to 5 min...


Citation and Details
More data for this
Ligand-Target Pair
Beta-mannosidase


(Bacteroides thetaiotaomicron)
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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PubMed
9.00E+6 -2.90n/an/an/an/an/a5.637



The Medical School, Newcastle University



Assay Description
Putative mannosidase assay using wild-type protein Btman2A. Enzyme inhibition assay.


Nat Chem Biol 4: 306-12 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50350758
PNG
(CHEMBL1818433)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6+/m1/s1
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n/an/a 510n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Glucosylceramidase


(Bos taurus)
BDBM50350758
PNG
(CHEMBL1818433)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6+/m1/s1
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n/an/a 6.30E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate ...


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50350758
PNG
(CHEMBL1818433)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6+/m1/s1
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n/an/a 5.40E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrat...


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
β-galactosidase


(Bos taurus (Bovine))
BDBM50350758
PNG
(CHEMBL1818433)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6+/m1/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-galactosidase assessed as production of p-nitrophenol by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50350759
PNG
(CHEMBL1818434)
Show SMILES OC[C@@H]1CNC[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6+/m0/s1
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n/an/a 9.00E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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n/an/a 120n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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n/an/a 2.90E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal isomaltase assessed as production of p-nitrophenol at by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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n/an/a 5.31E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal sucrase assessed as production of p-nitrophenol at by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Glucosylceramidase


(Bos taurus)
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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n/an/a 3.10E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate ...


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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n/an/a 63n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrat...


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
β-galactosidase


(Bos taurus (Bovine))
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-galactosidase assessed as production of p-nitrophenol by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50263043
PNG
(CHEMBL501385 | L-Isofagomine)
Show SMILES OC[C@@H]1CNC[C@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50263043
PNG
(CHEMBL501385 | L-Isofagomine)
Show SMILES OC[C@@H]1CNC[C@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m0/s1
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n/an/a 3.40E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal sucrase assessed as production of p-nitrophenol at by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Glucosylceramidase


(Bos taurus)
BDBM50263043
PNG
(CHEMBL501385 | L-Isofagomine)
Show SMILES OC[C@@H]1CNC[C@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m0/s1
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n/an/a 6.11E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate ...


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50263043
PNG
(CHEMBL501385 | L-Isofagomine)
Show SMILES OC[C@@H]1CNC[C@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m0/s1
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n/an/a 8.70E+3n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrat...


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
β-galactosidase


(Bos taurus (Bovine))
BDBM50263043
PNG
(CHEMBL501385 | L-Isofagomine)
Show SMILES OC[C@@H]1CNC[C@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m0/s1
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n/an/a 8.21E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-galactosidase assessed as production of p-nitrophenol by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50350761
PNG
(CHEMBL1818321)
Show SMILES OC[C@H]1CNC[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5+,6-/m1/s1
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n/an/a 5.20E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50350761
PNG
(CHEMBL1818321)
Show SMILES OC[C@H]1CNC[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5+,6-/m1/s1
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n/an/a 1.13E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrat...


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50350762
PNG
(CHEMBL1818322)
Show SMILES OC[C@@H]1CNC[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5+,6-/m0/s1
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n/an/a 4.69E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



National Center for Advancing Translation Sciences

Curated by ChEMBL


Assay Description
Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...


J Med Chem 55: 5734-48 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50263043
PNG
(CHEMBL501385 | L-Isofagomine)
Show SMILES OC[C@@H]1CNC[C@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m0/s1
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n/an/a 9.00E+3n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of human lysosomal beta-glucosidase


Bioorg Med Chem 16: 7330-6 (2008)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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n/an/a 60n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of human lysosomal beta-glucosidase


Bioorg Med Chem 16: 7330-6 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen debranching enzyme


(Oryctolagus cuniculus)
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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n/an/a 4.80E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle amylo-1,6-glucosidase


Bioorg Med Chem 16: 7330-6 (2008)

More data for this
Ligand-Target Pair
β-galactosidase


(Bos taurus (Bovine))
BDBM50350757
PNG
(CHEMBL1818432)
Show SMILES OC[C@@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5+,6+/m0/s1
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n/an/a 3.89E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-galactosidase assessed as production of p-nitrophenol by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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n/an/a 700n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of liver glycogen phosphorylase A


Bioorg Med Chem 16: 7330-6 (2008)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50350757
PNG
(CHEMBL1818432)
Show SMILES OC[C@@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5+,6+/m0/s1
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n/an/a 6.46E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50350756
PNG
(CHEMBL1818323)
Show SMILES OC[C@H]1CNC[C@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5+,6+/m1/s1
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n/an/a 2.11E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Bioorg Med Chem 19: 3558-68 (2011)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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n/an/a 59n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of GCase assessed as 4-methylumbelliferone release assay after 30 mins by fluorimetry


Nat Chem Biol 3: 101-7 (2007)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50288853
PNG
(1-Butyl-5-methyl-piperidine-3,4-diol | CHEMBL35602...)
Show SMILES CCCCN1CC(C)C(O)C(O)C1
Show InChI InChI=1S/C10H21NO2/c1-3-4-5-11-6-8(2)10(13)9(12)7-11/h8-10,12-13H,3-7H2,1-2H3
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n/an/a 8.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of beta-glucosidase from almonds(sigma G 4511).


Bioorg Med Chem Lett 6: 553-558 (1996)

More data for this
Ligand-Target Pair
Beta-galactosidase


(Homo sapiens)
BDBM50288853
PNG
(1-Butyl-5-methyl-piperidine-3,4-diol | CHEMBL35602...)
Show SMILES CCCCN1CC(C)C(O)C(O)C1
Show InChI InChI=1S/C10H21NO2/c1-3-4-5-11-6-8(2)10(13)9(12)7-11/h8-10,12-13H,3-7H2,1-2H3
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n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of beta-galactosidase from aspergillus oryzae (sigma G 7256).


Bioorg Med Chem Lett 6: 553-558 (1996)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50288853
PNG
(1-Butyl-5-methyl-piperidine-3,4-diol | CHEMBL35602...)
Show SMILES CCCCN1CC(C)C(O)C(O)C1
Show InChI InChI=1S/C10H21NO2/c1-3-4-5-11-6-8(2)10(13)9(12)7-11/h8-10,12-13H,3-7H2,1-2H3
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n/an/a 2.70E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of alpha-fucosidase from bovine kidney(sigma F 5884).


Bioorg Med Chem Lett 6: 553-558 (1996)

More data for this
Ligand-Target Pair
Alpha-glucosidase A (α-Gal A)


(Homo sapiens (Human))
BDBM50288853
PNG
(1-Butyl-5-methyl-piperidine-3,4-diol | CHEMBL35602...)
Show SMILES CCCCN1CC(C)C(O)C(O)C1
Show InChI InChI=1S/C10H21NO2/c1-3-4-5-11-6-8(2)10(13)9(12)7-11/h8-10,12-13H,3-7H2,1-2H3
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n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of alpha-galactosidase from green coffee beans (sigma G 8507).


Bioorg Med Chem Lett 6: 553-558 (1996)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50288853
PNG
(1-Butyl-5-methyl-piperidine-3,4-diol | CHEMBL35602...)
Show SMILES CCCCN1CC(C)C(O)C(O)C1
Show InChI InChI=1S/C10H21NO2/c1-3-4-5-11-6-8(2)10(13)9(12)7-11/h8-10,12-13H,3-7H2,1-2H3
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n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha-mannosidase


Bioorg Med Chem Lett 6: 553-558 (1996)

More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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n/an/a 1.21E+3n/an/an/an/an/an/a



The National Hellenic Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of non-phosphorylated form of rabbit muscle glycogen phosphorylase


J Med Chem 49: 5687-701 (2006)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
PDB
MMDB

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n/an/a 670n/an/an/an/an/an/a



The National Hellenic Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated form of pig liver glycogen phosphorylase


J Med Chem 49: 5687-701 (2006)

More data for this
Ligand-Target Pair
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