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36 similar compounds to monomer 50006708

Compile data set for download or QSAR
Wt: 326.3
BDBM50000415
Wt: 380.4
BDBM50043215
Wt: 340.4
BDBM110162
Wt: 354.4
BDBM110163
Wt: 344.4
BDBM50004590
Wt: 318.4
BDBM50004572
Wt: 352.4
BDBM50005376
Wt: 306.4
BDBM50005387
Wt: 354.4
BDBM50008413
Wt: 340.4
BDBM50006697
Wt: 366.4
BDBM50006701
Wt: 366.4
BDBM50006718
Wt: 352.4
BDBM50006721
Wt: 346.4
BDBM50006722
Wt: 354.4
BDBM50011216
Displayed 1 to 15 (of 36 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 51 hits for monomerid = 50000415,50043215,110162,110163,50004590,50004572,50005376,50005387,50008413,50006697,50006701,50006718,50006721,50006722,50011216   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50008413
PNG
(8-(1-Methyl-2-phenyl-ethyl)-1,3-dipropyl-3,7-dihyd...)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)[C@H](C)Cc1ccccc1
Show InChI InChI=1S/C20H26N4O2/c1-4-11-23-18-16(19(25)24(12-5-2)20(23)26)21-17(22-18)14(3)13-15-9-7-6-8-10-15/h6-10,14H,4-5,11-13H2,1-3H3,(H,21,22)/t14-/m1/s1
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6.90n/an/an/an/an/an/an/an/a



Marion Merrell Dow Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards adenosine A1 receptor was determined using radioligand [3H]-CHA in whole rat brain membranes at 25 degree C


J Med Chem 36: 4015-20 (1994)


Article DOI: 10.1021/jm00077a004
BindingDB Entry DOI: 10.7270/Q23T9G92
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50008413
PNG
(8-(1-Methyl-2-phenyl-ethyl)-1,3-dipropyl-3,7-dihyd...)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)[C@H](C)Cc1ccccc1
Show InChI InChI=1S/C20H26N4O2/c1-4-11-23-18-16(19(25)24(12-5-2)20(23)26)21-17(22-18)14(3)13-15-9-7-6-8-10-15/h6-10,14H,4-5,11-13H2,1-3H3,(H,21,22)/t14-/m1/s1
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6.90n/an/an/an/an/an/an/an/a



Merrell Dow Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to rat brain membrane Adenosine A1 receptor


J Med Chem 33: 3127-30 (1991)


Article DOI: 10.1021/jm00174a004
BindingDB Entry DOI: 10.7270/Q2ZC83GN
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50008413
PNG
(8-(1-Methyl-2-phenyl-ethyl)-1,3-dipropyl-3,7-dihyd...)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)[C@H](C)Cc1ccccc1
Show InChI InChI=1S/C20H26N4O2/c1-4-11-23-18-16(19(25)24(12-5-2)20(23)26)21-17(22-18)14(3)13-15-9-7-6-8-10-15/h6-10,14H,4-5,11-13H2,1-3H3,(H,21,22)/t14-/m1/s1
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6.90n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand


J Med Chem 35: 407-22 (1992)


Article DOI: 10.1021/jm00081a001
BindingDB Entry DOI: 10.7270/Q2Z89D1W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50011216
PNG
(1-Methyl-8-(1-methyl-2-phenyl-ethyl)-1,3-dipropyl-...)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C(C)Cc1ccccc1
Show InChI InChI=1S/C20H26N4O2/c1-4-11-23-18-16(19(25)24(12-5-2)20(23)26)21-17(22-18)14(3)13-15-9-7-6-8-10-15/h6-10,14H,4-5,11-13H2,1-3H3,(H,21,22)
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32.6n/an/an/an/an/an/an/an/a



Marion Merrell Dow Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards adenosine A1 receptor was determined using radioligand [3H]-CHA in whole rat brain membranes at 25 degree C


J Med Chem 36: 4015-20 (1994)


Article DOI: 10.1021/jm00077a004
BindingDB Entry DOI: 10.7270/Q23T9G92
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50011216
PNG
(1-Methyl-8-(1-methyl-2-phenyl-ethyl)-1,3-dipropyl-...)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C(C)Cc1ccccc1
Show InChI InChI=1S/C20H26N4O2/c1-4-11-23-18-16(19(25)24(12-5-2)20(23)26)21-17(22-18)14(3)13-15-9-7-6-8-10-15/h6-10,14H,4-5,11-13H2,1-3H3,(H,21,22)
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33n/an/an/an/an/an/an/an/a



Merrell Dow Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to rat brain membrane Adenosine A1 receptor


J Med Chem 33: 3127-30 (1991)


Article DOI: 10.1021/jm00174a004
BindingDB Entry DOI: 10.7270/Q2ZC83GN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50005387
PNG
(8-(2,2-Dimethyl-propyl)-1,3-dipropyl-3,7-dihydro-p...)
Show SMILES CCCn1c2nc(CC(C)(C)C)[nH]c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C16H26N4O2/c1-6-8-19-13-12(14(21)20(9-7-2)15(19)22)17-11(18-13)10-16(3,4)5/h6-10H2,1-5H3,(H,17,18)
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49n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor using N6-[3H]cyclohexyladenosine as radioligand in guinea pig forebrain membranes


J Med Chem 35: 924-30 (1992)


Article DOI: 10.1021/jm00083a018
BindingDB Entry DOI: 10.7270/Q2NS0VJZ
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50006697
PNG
(8-Phenethyl-1,3-dipropyl-3,7-dihydro-purine-2,6-di...)
Show SMILES CCCn1c2nc(CCc3ccccc3)[nH]c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C19H24N4O2/c1-3-12-22-17-16(18(24)23(13-4-2)19(22)25)20-15(21-17)11-10-14-8-6-5-7-9-14/h5-9H,3-4,10-13H2,1-2H3,(H,20,21)
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58n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat cortex by the displacement of [3H]-cyclohexyladenosine (CHA).


J Med Chem 34: 1431-5 (1991)


Article DOI: 10.1021/jm00108a029
BindingDB Entry DOI: 10.7270/Q2G73CP1
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50006697
PNG
(8-Phenethyl-1,3-dipropyl-3,7-dihydro-purine-2,6-di...)
Show SMILES CCCn1c2nc(CCc3ccccc3)[nH]c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C19H24N4O2/c1-3-12-22-17-16(18(24)23(13-4-2)19(22)25)20-15(21-17)11-10-14-8-6-5-7-9-14/h5-9H,3-4,10-13H2,1-2H3,(H,20,21)
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58n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of N6-[3H]-cyclohexyladenosine binding to adenosine A1 receptor from rat cortical membranes


J Med Chem 35: 2342-5 (1992)


Article DOI: 10.1021/jm00090a027
BindingDB Entry DOI: 10.7270/Q2T43S20
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50005376
PNG
(8-Indan-2-yl-1,3-dipropyl-3,7-dihydro-purine-2,6-d...)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C1Cc2ccccc2C1
Show InChI InChI=1S/C20H24N4O2/c1-3-9-23-18-16(19(25)24(10-4-2)20(23)26)21-17(22-18)15-11-13-7-5-6-8-14(13)12-15/h5-8,15H,3-4,9-12H2,1-2H3,(H,21,22)
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64.3n/an/an/an/an/an/an/an/a



Marion Merrell Dow Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards adenosine A1 receptor was determined using radioligand [3H]-CHA in whole rat brain membranes at 25 degree C


J Med Chem 36: 4015-20 (1994)


Article DOI: 10.1021/jm00077a004
BindingDB Entry DOI: 10.7270/Q23T9G92
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM110163
PNG
(8-(3-Phenylpropyl)-1,3,7-triethylxanthine (9d))
Show SMILES CCn1c(CCCc2ccccc2)nc2n(CC)c(=O)n(CC)c(=O)c12
Show InChI InChI=1S/C20H26N4O2/c1-4-22-16(14-10-13-15-11-8-7-9-12-15)21-18-17(22)19(25)24(6-3)20(26)23(18)5-2/h7-9,11-12H,4-6,10,13-14H2,1-3H3
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139n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DPCPX from Adenosine A1 receptor in Sprague-Dawley rat brain cortical membranes in absence of GTP


Bioorg Med Chem 23: 6641-9 (2015)


Article DOI: 10.1016/j.bmc.2015.09.012
BindingDB Entry DOI: 10.7270/Q2571DTP
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50008413
PNG
(8-(1-Methyl-2-phenyl-ethyl)-1,3-dipropyl-3,7-dihyd...)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)[C@H](C)Cc1ccccc1
Show InChI InChI=1S/C20H26N4O2/c1-4-11-23-18-16(19(25)24(12-5-2)20(23)26)21-17(22-18)14(3)13-15-9-7-6-8-10-15/h6-10,14H,4-5,11-13H2,1-3H3,(H,21,22)/t14-/m1/s1
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157n/an/an/an/an/an/an/an/a



Merrell Dow Research Institute

Curated by ChEMBL


Assay Description
Binding of Adenosine A2 receptor in whole rat brain membrane using [3H]CHA as a Radioligand


J Med Chem 33: 3127-30 (1991)


Article DOI: 10.1021/jm00174a004
BindingDB Entry DOI: 10.7270/Q2ZC83GN
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM110163
PNG
(8-(3-Phenylpropyl)-1,3,7-triethylxanthine (9d))
Show SMILES CCn1c(CCCc2ccccc2)nc2n(CC)c(=O)n(CC)c(=O)c12
Show InChI InChI=1S/C20H26N4O2/c1-4-22-16(14-10-13-15-11-8-7-9-12-15)21-18-17(22)19(25)24(6-3)20(26)23(18)5-2/h7-9,11-12H,4-6,10,13-14H2,1-3H3
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164n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DPCPX from Adenosine A1 receptor in Sprague-Dawley rat whole brain membranes


Bioorg Med Chem 23: 6641-9 (2015)


Article DOI: 10.1016/j.bmc.2015.09.012
BindingDB Entry DOI: 10.7270/Q2571DTP
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM110163
PNG
(8-(3-Phenylpropyl)-1,3,7-triethylxanthine (9d))
Show SMILES CCn1c(CCCc2ccccc2)nc2n(CC)c(=O)n(CC)c(=O)c12
Show InChI InChI=1S/C20H26N4O2/c1-4-22-16(14-10-13-15-11-8-7-9-12-15)21-18-17(22)19(25)24(6-3)20(26)23(18)5-2/h7-9,11-12H,4-6,10,13-14H2,1-3H3
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164n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DPCPX from Adenosine A1 receptor in Sprague-Dawley rat whole brain membranes in absence of GTP


Bioorg Med Chem 23: 6641-9 (2015)


Article DOI: 10.1016/j.bmc.2015.09.012
BindingDB Entry DOI: 10.7270/Q2571DTP
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50043215
PNG
(8-(2-Phenyl-cyclopentyl)-1,3-dipropyl-3,9-dihydro-...)
Show SMILES CCCn1c2[nH]c(nc2c(=O)n(CCC)c1=O)[C@H]1CCC[C@@H]1c1ccccc1
Show InChI InChI=1S/C22H28N4O2/c1-3-13-25-20-18(21(27)26(14-4-2)22(25)28)23-19(24-20)17-12-8-11-16(17)15-9-6-5-7-10-15/h5-7,9-10,16-17H,3-4,8,11-14H2,1-2H3,(H,23,24)/t16-,17+/m1/s1
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164n/an/an/an/an/an/an/an/a



Marion Merrell Dow Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards adenosine A1 receptor was determined using radioligand [3H]-CHA in whole rat brain membranes at 25 degree C


J Med Chem 36: 4015-20 (1994)


Article DOI: 10.1021/jm00077a004
BindingDB Entry DOI: 10.7270/Q23T9G92
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM110163
PNG
(8-(3-Phenylpropyl)-1,3,7-triethylxanthine (9d))
Show SMILES CCn1c(CCCc2ccccc2)nc2n(CC)c(=O)n(CC)c(=O)c12
Show InChI InChI=1S/C20H26N4O2/c1-4-22-16(14-10-13-15-11-8-7-9-12-15)21-18-17(22)19(25)24(6-3)20(26)23(18)5-2/h7-9,11-12H,4-6,10,13-14H2,1-3H3
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209n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DPCPX from Adenosine A1 receptor in Sprague-Dawley rat whole brain membranes in presence of 0.1 mM GTP


Bioorg Med Chem 23: 6641-9 (2015)


Article DOI: 10.1016/j.bmc.2015.09.012
BindingDB Entry DOI: 10.7270/Q2571DTP
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Homo sapiens (Human))
BDBM50004572
PNG
(8-Cyclopentyl-7-methyl-1,3-dipropyl-3,7-dihydro-pu...)
Show SMILES CCCn1c2nc(C3CCCC3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C17H26N4O2/c1-4-10-20-15-13(16(22)21(11-5-2)17(20)23)19(3)14(18-15)12-8-6-7-9-12/h12H,4-11H2,1-3H3
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220n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes.


J Med Chem 32: 1231-7 (1989)


Article DOI: 10.1021/jm00126a014
BindingDB Entry DOI: 10.7270/Q2PZ57T1
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50005376
PNG
(8-Indan-2-yl-1,3-dipropyl-3,7-dihydro-purine-2,6-d...)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C1Cc2ccccc2C1
Show InChI InChI=1S/C20H24N4O2/c1-3-9-23-18-16(19(25)24(10-4-2)20(23)26)21-17(22-18)15-11-13-7-5-6-8-14(13)12-15/h5-8,15H,3-4,9-12H2,1-2H3,(H,21,22)
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220n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor using N6-[3H]cyclohexyladenosine as radioligand in guinea pig forebrain membranes


J Med Chem 35: 924-30 (1992)


Article DOI: 10.1021/jm00083a018
BindingDB Entry DOI: 10.7270/Q2NS0VJZ
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM110163
PNG
(8-(3-Phenylpropyl)-1,3,7-triethylxanthine (9d))
Show SMILES CCn1c(CCCc2ccccc2)nc2n(CC)c(=O)n(CC)c(=O)c12
Show InChI InChI=1S/C20H26N4O2/c1-4-22-16(14-10-13-15-11-8-7-9-12-15)21-18-17(22)19(25)24(6-3)20(26)23(18)5-2/h7-9,11-12H,4-6,10,13-14H2,1-3H3
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258n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DPCPX from Adenosine A1 receptor in Sprague-Dawley rat brain cortical membranes in presence of 0.1 mM GTP


Bioorg Med Chem 23: 6641-9 (2015)


Article DOI: 10.1016/j.bmc.2015.09.012
BindingDB Entry DOI: 10.7270/Q2571DTP
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50011216
PNG
(1-Methyl-8-(1-methyl-2-phenyl-ethyl)-1,3-dipropyl-...)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C(C)Cc1ccccc1
Show InChI InChI=1S/C20H26N4O2/c1-4-11-23-18-16(19(25)24(12-5-2)20(23)26)21-17(22-18)14(3)13-15-9-7-6-8-10-15/h6-10,14H,4-5,11-13H2,1-3H3,(H,21,22)
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260n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity carried out with [3H]-cyclohexyladenosine in guinea pig forebrain membranes against adenosine A1 receptor


J Med Chem 34: 466-9 (1991)


Article DOI: 10.1021/jm00105a072
BindingDB Entry DOI: 10.7270/Q2154G0Z
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50011216
PNG
(1-Methyl-8-(1-methyl-2-phenyl-ethyl)-1,3-dipropyl-...)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C(C)Cc1ccccc1
Show InChI InChI=1S/C20H26N4O2/c1-4-11-23-18-16(19(25)24(12-5-2)20(23)26)21-17(22-18)14(3)13-15-9-7-6-8-10-15/h6-10,14H,4-5,11-13H2,1-3H3,(H,21,22)
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480n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity carried out with [3H]5'-(N-ethylcarbamoyl)-adenosine in the presence of 50 nM cyclopentyladenosine in rat striatal membranes against...


J Med Chem 34: 466-9 (1991)


Article DOI: 10.1021/jm00105a072
BindingDB Entry DOI: 10.7270/Q2154G0Z
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50006697
PNG
(8-Phenethyl-1,3-dipropyl-3,7-dihydro-purine-2,6-di...)
Show SMILES CCCn1c2nc(CCc3ccccc3)[nH]c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C19H24N4O2/c1-3-12-22-17-16(18(24)23(13-4-2)19(22)25)20-15(21-17)11-10-14-8-6-5-7-9-14/h5-9H,3-4,10-13H2,1-2H3,(H,20,21)
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560n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor from guinea pig forebrain membranes, using N6-[3H]-cyclohexyladenosine as radioligand.


J Med Chem 35: 2342-5 (1992)


Article DOI: 10.1021/jm00090a027
BindingDB Entry DOI: 10.7270/Q2T43S20
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50006697
PNG
(8-Phenethyl-1,3-dipropyl-3,7-dihydro-purine-2,6-di...)
Show SMILES CCCn1c2nc(CCc3ccccc3)[nH]c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C19H24N4O2/c1-3-12-22-17-16(18(24)23(13-4-2)19(22)25)20-15(21-17)11-10-14-8-6-5-7-9-14/h5-9H,3-4,10-13H2,1-2H3,(H,20,21)
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593n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatum by the displacement of [3H]N-ethyladenosine-5''-uronamide(NECA).


J Med Chem 34: 1431-5 (1991)


Article DOI: 10.1021/jm00108a029
BindingDB Entry DOI: 10.7270/Q2G73CP1
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50006697
PNG
(8-Phenethyl-1,3-dipropyl-3,7-dihydro-purine-2,6-di...)
Show SMILES CCCn1c2nc(CCc3ccccc3)[nH]c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C19H24N4O2/c1-3-12-22-17-16(18(24)23(13-4-2)19(22)25)20-15(21-17)11-10-14-8-6-5-7-9-14/h5-9H,3-4,10-13H2,1-2H3,(H,20,21)
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593n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of N-[3H]-ethyladenosin-5''-uronamide binding to adenosine A2 receptor from rat striatal membranes


J Med Chem 35: 2342-5 (1992)


Article DOI: 10.1021/jm00090a027
BindingDB Entry DOI: 10.7270/Q2T43S20
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50011216
PNG
(1-Methyl-8-(1-methyl-2-phenyl-ethyl)-1,3-dipropyl-...)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C(C)Cc1ccccc1
Show InChI InChI=1S/C20H26N4O2/c1-4-11-23-18-16(19(25)24(12-5-2)20(23)26)21-17(22-18)14(3)13-15-9-7-6-8-10-15/h6-10,14H,4-5,11-13H2,1-3H3,(H,21,22)
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644n/an/an/an/an/an/an/an/a



Merrell Dow Research Institute

Curated by ChEMBL


Assay Description
Binding of Adenosine A2 receptor in whole rat brain membrane using [3H]CHA as a Radioligand


J Med Chem 33: 3127-30 (1991)


Article DOI: 10.1021/jm00174a004
BindingDB Entry DOI: 10.7270/Q2ZC83GN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50006721
PNG
(8-(3-Phenyl-allyl)-1,3-dipropyl-3,7-dihydro-purine...)
Show SMILES CCCn1c2nc(CC=Cc3ccccc3)[nH]c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C20H24N4O2/c1-3-13-23-18-17(19(25)24(14-4-2)20(23)26)21-16(22-18)12-8-11-15-9-6-5-7-10-15/h5-11H,3-4,12-14H2,1-2H3,(H,21,22)
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870n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor from guinea pig forebrain membranes, using N6-[3H]-cyclohexyladenosine as radioligand.


J Med Chem 35: 2342-5 (1992)


Article DOI: 10.1021/jm00090a027
BindingDB Entry DOI: 10.7270/Q2T43S20
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50000415
PNG
(CHEMBL156622)
Show SMILES CCCn1c2[nH]c(Cc3ccccc3)nc2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C18H22N4O2/c1-3-10-21-16-15(17(23)22(11-4-2)18(21)24)19-14(20-16)12-13-8-6-5-7-9-13/h5-9H,3-4,10-12H2,1-2H3,(H,19,20)
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891n/an/an/an/an/an/an/an/a



Center for Bio-Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Evaluated for binding affinity against Adenosine A1 receptor


J Med Chem 35: 629-35 (1992)

Checked by Author
Article DOI: 10.1021/jm00082a003
BindingDB Entry DOI: 10.7270/Q23R0V5Q
More data for this
Ligand-Target Pair
Adenosine Receptors A2a (A2a)


(Rattus norvegicus (rat))
BDBM110162
PNG
(8-(3-Phenylpropyl)-1,3-diethyl-7-methylxanthine (9...)
Show SMILES CCn1c2nc(CCCc3ccccc3)n(C)c2c(=O)n(CC)c1=O
Show InChI InChI=1S/C19H24N4O2/c1-4-22-17-16(18(24)23(5-2)19(22)25)21(3)15(20-17)13-9-12-14-10-7-6-8-11-14/h6-8,10-11H,4-5,9,12-13H2,1-3H3
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>1.00E+3n/an/an/an/an/an/an/an/a



North-West University, Private Bag X6001, Potchefstroom 2520, South Africa





Bioorg Chem 49: 49-58 (2013)


Article DOI: 10.1016/j.bioorg.2013.06.006
BindingDB Entry DOI: 10.7270/Q21V5CM2
More data for this
Ligand-Target Pair
Adenosine Receptors A2a (A2a)


(Rattus norvegicus (rat))
BDBM110163
PNG
(8-(3-Phenylpropyl)-1,3,7-triethylxanthine (9d))
Show SMILES CCn1c(CCCc2ccccc2)nc2n(CC)c(=O)n(CC)c(=O)c12
Show InChI InChI=1S/C20H26N4O2/c1-4-22-16(14-10-13-15-11-8-7-9-12-15)21-18-17(22)19(25)24(6-3)20(26)23(18)5-2/h7-9,11-12H,4-6,10,13-14H2,1-3H3
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>1.00E+3n/an/an/an/an/an/an/an/a



North-West University, Private Bag X6001, Potchefstroom 2520, South Africa





Bioorg Chem 49: 49-58 (2013)


Article DOI: 10.1016/j.bioorg.2013.06.006
BindingDB Entry DOI: 10.7270/Q21V5CM2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM110162
PNG
(8-(3-Phenylpropyl)-1,3-diethyl-7-methylxanthine (9...)
Show SMILES CCn1c2nc(CCCc3ccccc3)n(C)c2c(=O)n(CC)c1=O
Show InChI InChI=1S/C19H24N4O2/c1-4-22-17-16(18(24)23(5-2)19(22)25)21(3)15(20-17)13-9-12-14-10-7-6-8-11-14/h6-8,10-11H,4-5,9,12-13H2,1-3H3
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1.24E+3n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DPCPX from Adenosine A1 receptor in Sprague-Dawley rat whole brain membranes


Bioorg Med Chem 23: 6641-9 (2015)


Article DOI: 10.1016/j.bmc.2015.09.012
BindingDB Entry DOI: 10.7270/Q2571DTP
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50006722
PNG
(8-(2-Cyclopentyl-ethyl)-7-methyl-1,3-dipropyl-3,7-...)
Show SMILES CCCn1c2nc(CCC3CCCC3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C19H30N4O2/c1-4-12-22-17-16(18(24)23(13-5-2)19(22)25)21(3)15(20-17)11-10-14-8-6-7-9-14/h14H,4-13H2,1-3H3
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1.30E+3n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor from guinea pig forebrain membranes, using N6-[3H]-cyclohexyladenosine as radioligand.


J Med Chem 35: 2342-5 (1992)


Article DOI: 10.1021/jm00090a027
BindingDB Entry DOI: 10.7270/Q2T43S20
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50006721
PNG
(8-(3-Phenyl-allyl)-1,3-dipropyl-3,7-dihydro-purine...)
Show SMILES CCCn1c2nc(CC=Cc3ccccc3)[nH]c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C20H24N4O2/c1-3-13-23-18-17(19(25)24(14-4-2)20(23)26)21-16(22-18)12-8-11-15-9-6-5-7-10-15/h5-11H,3-4,12-14H2,1-2H3,(H,21,22)
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1.60E+3n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor from rat striatal membranes, using N-[3H]-ethyladenosin-5''-uronamide as radioligand (in the presence ...


J Med Chem 35: 2342-5 (1992)


Article DOI: 10.1021/jm00090a027
BindingDB Entry DOI: 10.7270/Q2T43S20
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50005376
PNG
(8-Indan-2-yl-1,3-dipropyl-3,7-dihydro-purine-2,6-d...)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C1Cc2ccccc2C1
Show InChI InChI=1S/C20H24N4O2/c1-3-9-23-18-16(19(25)24(10-4-2)20(23)26)21-17(22-18)15-11-13-7-5-6-8-14(13)12-15/h5-8,15H,3-4,9-12H2,1-2H3,(H,21,22)
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1.70E+3n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor using N-[3H]-ethyladenosin-5''-uronamide as radioligand in rat striatal membranes.


J Med Chem 35: 924-30 (1992)


Article DOI: 10.1021/jm00083a018
BindingDB Entry DOI: 10.7270/Q2NS0VJZ
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50006701
PNG
(7-Methyl-8-(3-phenyl-allyl)-1,3-dipropyl-3,7-dihyd...)
Show SMILES CCCn1c2nc(C\C=C\c3ccccc3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C21H26N4O2/c1-4-14-24-19-18(20(26)25(15-5-2)21(24)27)23(3)17(22-19)13-9-12-16-10-7-6-8-11-16/h6-12H,4-5,13-15H2,1-3H3/b12-9+
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1.80E+3n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor from rat striatal membranes, using N-[3H]-ethyladenosin-5''-uronamide as radioligand (in the presence ...


J Med Chem 35: 2342-5 (1992)


Article DOI: 10.1021/jm00090a027
BindingDB Entry DOI: 10.7270/Q2T43S20
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50004572
PNG
(8-Cyclopentyl-7-methyl-1,3-dipropyl-3,7-dihydro-pu...)
Show SMILES CCCn1c2nc(C3CCCC3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C17H26N4O2/c1-4-10-20-15-13(16(22)21(11-5-2)17(20)23)19(3)14(18-15)12-8-6-7-9-12/h12H,4-11H2,1-3H3
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2.30E+3n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranes


J Med Chem 32: 1231-7 (1989)


Article DOI: 10.1021/jm00126a014
BindingDB Entry DOI: 10.7270/Q2PZ57T1
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50004572
PNG
(8-Cyclopentyl-7-methyl-1,3-dipropyl-3,7-dihydro-pu...)
Show SMILES CCCn1c2nc(C3CCCC3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C17H26N4O2/c1-4-10-20-15-13(16(22)21(11-5-2)17(20)23)19(3)14(18-15)12-8-6-7-9-12/h12H,4-11H2,1-3H3
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2.30E+3n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of (R)-N6-([3H]-phenylisopropyl) adenosine binding to adenosine A1 receptor from rat cortical membranes


J Med Chem 35: 2342-5 (1992)


Article DOI: 10.1021/jm00090a027
BindingDB Entry DOI: 10.7270/Q2T43S20
More data for this
Ligand-Target Pair
Adenosine Receptors A2a (A2a)


(Rattus norvegicus (rat))
BDBM110163
PNG
(8-(3-Phenylpropyl)-1,3,7-triethylxanthine (9d))
Show SMILES CCn1c(CCCc2ccccc2)nc2n(CC)c(=O)n(CC)c(=O)c12
Show InChI InChI=1S/C20H26N4O2/c1-4-22-16(14-10-13-15-11-8-7-9-12-15)21-18-17(22)19(25)24(6-3)20(26)23(18)5-2/h7-9,11-12H,4-6,10,13-14H2,1-3H3
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2.71E+3n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from Adenosine A2A receptor in Sprague-Dawley rat striatal membranes


Bioorg Med Chem 23: 6641-9 (2015)


Article DOI: 10.1016/j.bmc.2015.09.012
BindingDB Entry DOI: 10.7270/Q2571DTP
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50006701
PNG
(7-Methyl-8-(3-phenyl-allyl)-1,3-dipropyl-3,7-dihyd...)
Show SMILES CCCn1c2nc(C\C=C\c3ccccc3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C21H26N4O2/c1-4-14-24-19-18(20(26)25(15-5-2)21(24)27)23(3)17(22-19)13-9-12-16-10-7-6-8-11-16/h6-12H,4-5,13-15H2,1-3H3/b12-9+
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3.50E+3n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor from guinea pig forebrain membranes, using N6-[3H]-cyclohexyladenosine as radioligand.


J Med Chem 35: 2342-5 (1992)


Article DOI: 10.1021/jm00090a027
BindingDB Entry DOI: 10.7270/Q2T43S20
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50004572
PNG
(8-Cyclopentyl-7-methyl-1,3-dipropyl-3,7-dihydro-pu...)
Show SMILES CCCn1c2nc(C3CCCC3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C17H26N4O2/c1-4-10-20-15-13(16(22)21(11-5-2)17(20)23)19(3)14(18-15)12-8-6-7-9-12/h12H,4-11H2,1-3H3
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3.90E+3n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]cyclohexyladenosine as radioligand


J Med Chem 35: 3066-75 (1992)


Article DOI: 10.1021/jm00094a022
BindingDB Entry DOI: 10.7270/Q2DN45PF
More data for this
Ligand-Target Pair
Adenosine Receptors A2a (A2a)


(Rattus norvegicus (rat))
BDBM110162
PNG
(8-(3-Phenylpropyl)-1,3-diethyl-7-methylxanthine (9...)
Show SMILES CCn1c2nc(CCCc3ccccc3)n(C)c2c(=O)n(CC)c1=O
Show InChI InChI=1S/C19H24N4O2/c1-4-22-17-16(18(24)23(5-2)19(22)25)21(3)15(20-17)13-9-12-14-10-7-6-8-11-14/h6-8,10-11H,4-5,9,12-13H2,1-3H3
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3.93E+3n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from Adenosine A2A receptor in Sprague-Dawley rat striatal membranes


Bioorg Med Chem 23: 6641-9 (2015)


Article DOI: 10.1016/j.bmc.2015.09.012
BindingDB Entry DOI: 10.7270/Q2571DTP
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50005387
PNG
(8-(2,2-Dimethyl-propyl)-1,3-dipropyl-3,7-dihydro-p...)
Show SMILES CCCn1c2nc(CC(C)(C)C)[nH]c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C16H26N4O2/c1-6-8-19-13-12(14(21)20(9-7-2)15(19)22)17-11(18-13)10-16(3,4)5/h6-10H2,1-5H3,(H,17,18)
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PubMed
6.00E+3n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor using N-[3H]-ethyladenosin-5''-uronamide as radioligand in rat striatal membranes.


J Med Chem 35: 924-30 (1992)


Article DOI: 10.1021/jm00083a018
BindingDB Entry DOI: 10.7270/Q2NS0VJZ
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50006697
PNG
(8-Phenethyl-1,3-dipropyl-3,7-dihydro-purine-2,6-di...)
Show SMILES CCCn1c2nc(CCc3ccccc3)[nH]c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C19H24N4O2/c1-3-12-22-17-16(18(24)23(13-4-2)19(22)25)20-15(21-17)11-10-14-8-6-5-7-9-14/h5-9H,3-4,10-13H2,1-2H3,(H,20,21)
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PubMed
6.20E+3n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor from rat striatal membranes, using N-[3H]-ethyladenosin-5''-uronamide as radioligand (in the presence ...


J Med Chem 35: 2342-5 (1992)


Article DOI: 10.1021/jm00090a027
BindingDB Entry DOI: 10.7270/Q2T43S20
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50004590
PNG
(8-Dicyclopropylmethyl-7-methyl-1,3-dipropyl-3,7-di...)
Show SMILES CCCn1c2nc(C(C3CC3)C3CC3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C19H28N4O2/c1-4-10-22-17-15(18(24)23(11-5-2)19(22)25)21(3)16(20-17)14(12-6-7-12)13-8-9-13/h12-14H,4-11H2,1-3H3
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PubMed
7.40E+3n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity carried out with [3H]-cyclohexyladenosine in guinea pig forebrain membranes against adenosine A1 receptor


J Med Chem 34: 466-9 (1991)


Article DOI: 10.1021/jm00105a072
BindingDB Entry DOI: 10.7270/Q2154G0Z
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50004590
PNG
(8-Dicyclopropylmethyl-7-methyl-1,3-dipropyl-3,7-di...)
Show SMILES CCCn1c2nc(C(C3CC3)C3CC3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C19H28N4O2/c1-4-10-22-17-15(18(24)23(11-5-2)19(22)25)21(3)16(20-17)14(12-6-7-12)13-8-9-13/h12-14H,4-11H2,1-3H3
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7.40E+3n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]cyclohexyladenosine as radioligand


J Med Chem 35: 3066-75 (1992)


Article DOI: 10.1021/jm00094a022
BindingDB Entry DOI: 10.7270/Q2DN45PF
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50004572
PNG
(8-Cyclopentyl-7-methyl-1,3-dipropyl-3,7-dihydro-pu...)
Show SMILES CCCn1c2nc(C3CCCC3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C17H26N4O2/c1-4-10-20-15-13(16(22)21(11-5-2)17(20)23)19(3)14(18-15)12-8-6-7-9-12/h12H,4-11H2,1-3H3
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PubMed
8.10E+3n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor from guinea pig forebrain membranes, using N6-[3H]-cyclohexyladenosine as radioligand.


J Med Chem 35: 2342-5 (1992)


Article DOI: 10.1021/jm00090a027
BindingDB Entry DOI: 10.7270/Q2T43S20
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50006718
PNG
(7-Methyl-8-(1-methyl-2-phenyl-vinyl)-1,3-dipropyl-...)
Show SMILES CCCn1c2nc(\C(C)=C\c3ccccc3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C21H26N4O2/c1-5-12-24-19-17(20(26)25(13-6-2)21(24)27)23(4)18(22-19)15(3)14-16-10-8-7-9-11-16/h7-11,14H,5-6,12-13H2,1-4H3/b15-14+
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor from rat striatal membranes, using N-[3H]-ethyladenosin-5''-uronamide as radioligand (in the presence ...


J Med Chem 35: 2342-5 (1992)


Article DOI: 10.1021/jm00090a027
BindingDB Entry DOI: 10.7270/Q2T43S20
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50006718
PNG
(7-Methyl-8-(1-methyl-2-phenyl-vinyl)-1,3-dipropyl-...)
Show SMILES CCCn1c2nc(\C(C)=C\c3ccccc3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C21H26N4O2/c1-5-12-24-19-17(20(26)25(13-6-2)21(24)27)23(4)18(22-19)15(3)14-16-10-8-7-9-11-16/h7-11,14H,5-6,12-13H2,1-4H3/b15-14+
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>1.00E+4n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor from guinea pig forebrain membranes, using N6-[3H]-cyclohexyladenosine as radioligand.


J Med Chem 35: 2342-5 (1992)


Article DOI: 10.1021/jm00090a027
BindingDB Entry DOI: 10.7270/Q2T43S20
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50006722
PNG
(8-(2-Cyclopentyl-ethyl)-7-methyl-1,3-dipropyl-3,7-...)
Show SMILES CCCn1c2nc(CCC3CCCC3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C19H30N4O2/c1-4-12-22-17-16(18(24)23(13-5-2)19(22)25)21(3)15(20-17)11-10-14-8-6-7-9-14/h14H,4-13H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor from rat striatal membranes, using N-[3H]-ethyladenosin-5''-uronamide as radioligand (in the presence ...


J Med Chem 35: 2342-5 (1992)


Article DOI: 10.1021/jm00090a027
BindingDB Entry DOI: 10.7270/Q2T43S20
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50004572
PNG
(8-Cyclopentyl-7-methyl-1,3-dipropyl-3,7-dihydro-pu...)
Show SMILES CCCn1c2nc(C3CCCC3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C17H26N4O2/c1-4-10-20-15-13(16(22)21(11-5-2)17(20)23)19(3)14(18-15)12-8-6-7-9-12/h12H,4-11H2,1-3H3
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligand in the presence of 5...


J Med Chem 35: 3066-75 (1992)


Article DOI: 10.1021/jm00094a022
BindingDB Entry DOI: 10.7270/Q2DN45PF
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50004590
PNG
(8-Dicyclopropylmethyl-7-methyl-1,3-dipropyl-3,7-di...)
Show SMILES CCCn1c2nc(C(C3CC3)C3CC3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C19H28N4O2/c1-4-10-22-17-15(18(24)23(11-5-2)19(22)25)21(3)16(20-17)14(12-6-7-12)13-8-9-13/h12-14H,4-11H2,1-3H3
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PubMed
2.90E+4n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligand in the presence of 5...


J Med Chem 35: 3066-75 (1992)


Article DOI: 10.1021/jm00094a022
BindingDB Entry DOI: 10.7270/Q2DN45PF
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50004590
PNG
(8-Dicyclopropylmethyl-7-methyl-1,3-dipropyl-3,7-di...)
Show SMILES CCCn1c2nc(C(C3CC3)C3CC3)n(C)c2c(=O)n(CCC)c1=O
Show InChI InChI=1S/C19H28N4O2/c1-4-10-22-17-15(18(24)23(11-5-2)19(22)25)21(3)16(20-17)14(12-6-7-12)13-8-9-13/h12-14H,4-11H2,1-3H3
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PubMed
2.90E+4n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity carried out with [3H]5'-(N-ethylcarbamoyl)-adenosine in the presence of 50 nM cyclopentyladenosine in rat striatal membranes against...


J Med Chem 34: 466-9 (1991)


Article DOI: 10.1021/jm00105a072
BindingDB Entry DOI: 10.7270/Q2154G0Z
More data for this
Ligand-Target Pair
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