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6 similar compounds to monomer 50118939

Compile data set for download or QSAR
Wt: 294.3
BDBM11126
Wt: 234.2
BDBM50118937
Wt: 382.4
BDBM50130616
Wt: 234.2
BDBM50243456
Wt: 218.2
BDBM50243410
Purchase
Wt: 282.3
BDBM50273672

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 11126,50118937,50130616,50243456,50243410,50273672   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11126
PNG
((2S)-2-amino-3-(4-phenylphenyl)-1-(pyrrolidin-1-yl...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCCC1
Show InChI InChI=1/C19H22N2O/c20-18(19(22)21-12-4-5-13-21)14-15-8-10-17(11-9-15)16-6-2-1-3-7-16/h1-3,6-11,18H,4-5,12-14,20H2/t18-/s2
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1.16E+3 -8.09n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50130616
PNG
(2-Amino-N-[4-(2-amino-3-phenyl-propionylamino)-but...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)NCCCCNC(=O)[C@H](N)Cc1ccccc1
Show InChI InChI=1S/C22H30N4O2/c23-19(15-17-9-3-1-4-10-17)21(27)25-13-7-8-14-26-22(28)20(24)16-18-11-5-2-6-12-18/h1-6,9-12,19-20H,7-8,13-16,23-24H2,(H,25,27)(H,26,28)/t19-,20+
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1.53E+3n/an/an/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 using [3H]-DAGO in rat brain P2 synaptosomal preparation


J Med Chem 46: 3201-9 (2003)


Article DOI: 10.1021/jm020459z
BindingDB Entry DOI: 10.7270/Q28C9VMQ
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50130616
PNG
(2-Amino-N-[4-(2-amino-3-phenyl-propionylamino)-but...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)NCCCCNC(=O)[C@H](N)Cc1ccccc1
Show InChI InChI=1S/C22H30N4O2/c23-19(15-17-9-3-1-4-10-17)21(27)25-13-7-8-14-26-22(28)20(24)16-18-11-5-2-6-12-18/h1-6,9-12,19-20H,7-8,13-16,23-24H2,(H,25,27)(H,26,28)/t19-,20+
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4.62E+4n/an/an/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 using [3H]-DPDPE in rat brain P2 synaptosomal preparation


J Med Chem 46: 3201-9 (2003)


Article DOI: 10.1021/jm020459z
BindingDB Entry DOI: 10.7270/Q28C9VMQ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50243410
PNG
((S)-2-amino-3-phenyl-1-(pyrrolidin-1-yl)propan-1-o...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N1CCCC1
Show InChI InChI=1/C13H18N2O/c14-12(10-11-6-2-1-3-7-11)13(16)15-8-4-5-9-15/h1-3,6-7,12H,4-5,8-10,14H2/t12-/s2
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n/an/a 2.10E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP4 (unknown origin)


Bioorg Med Chem Lett 18: 4154-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.080
BindingDB Entry DOI: 10.7270/Q2G160N3
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50243456
PNG
((S)-2-amino-3-(4-hydroxyphenyl)-1-(pyrrolidin-1-yl...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCCC1
Show InChI InChI=1/C13H18N2O2/c14-12(13(17)15-7-1-2-8-15)9-10-3-5-11(16)6-4-10/h3-6,12,16H,1-2,7-9,14H2/t12-/s2
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n/an/a 1.57E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP2 (unknown origin)


Bioorg Med Chem Lett 18: 4154-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.080
BindingDB Entry DOI: 10.7270/Q2G160N3
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50243410
PNG
((S)-2-amino-3-phenyl-1-(pyrrolidin-1-yl)propan-1-o...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N1CCCC1
Show InChI InChI=1/C13H18N2O/c14-12(10-11-6-2-1-3-7-11)13(16)15-8-4-5-9-15/h1-3,6-7,12H,4-5,8-10,14H2/t12-/s2
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n/an/a 7.90E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP2 (unknown origin)


Bioorg Med Chem Lett 18: 4154-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.080
BindingDB Entry DOI: 10.7270/Q2G160N3
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50243456
PNG
((S)-2-amino-3-(4-hydroxyphenyl)-1-(pyrrolidin-1-yl...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCCC1
Show InChI InChI=1/C13H18N2O2/c14-12(13(17)15-7-1-2-8-15)9-10-3-5-11(16)6-4-10/h3-6,12,16H,1-2,7-9,14H2/t12-/s2
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n/an/a 9.50E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin)


Bioorg Med Chem Lett 18: 4154-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.080
BindingDB Entry DOI: 10.7270/Q2G160N3
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50243410
PNG
((S)-2-amino-3-phenyl-1-(pyrrolidin-1-yl)propan-1-o...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N1CCCC1
Show InChI InChI=1/C13H18N2O/c14-12(10-11-6-2-1-3-7-11)13(16)15-8-4-5-9-15/h1-3,6-7,12H,4-5,8-10,14H2/t12-/s2
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n/an/a 1.15E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin)


Bioorg Med Chem Lett 18: 4154-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.080
BindingDB Entry DOI: 10.7270/Q2G160N3
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))
BDBM50273672
PNG
(CHEMBL459540 | N-[(2R)-2-Amino-3-phenylpropyl]-3-p...)
Show SMILES N[C@@H](CNC(=O)CCc1ccccc1)Cc1ccccc1
Show InChI InChI=1/C18H22N2O/c19-17(13-16-9-5-2-6-10-16)14-20-18(21)12-11-15-7-3-1-4-8-15/h1-10,17H,11-14,19H2,(H,20,21)/t17-/s2
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n/an/a 5.47E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of MMP2


Bioorg Med Chem 16: 9984-90 (2008)


Article DOI: 10.1016/j.bmc.2008.10.025
BindingDB Entry DOI: 10.7270/Q2JQ10VD
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50118937
PNG
(2-Amino-3-(4-hydroxy-phenyl)-1-pyrrolidin-1-yl-pro...)
Show SMILES NC(Cc1ccc(O)cc1)C(=O)N1CCCC1
Show InChI InChI=1/C13H18N2O2/c14-12(13(17)15-7-1-2-8-15)9-10-3-5-11(16)6-4-10/h3-6,12,16H,1-2,7-9,14H2
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Antwerp (UIA)

Curated by ChEMBL


Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV.


Bioorg Med Chem Lett 12: 2825-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00603-0
BindingDB Entry DOI: 10.7270/Q279457M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50118937
PNG
(2-Amino-3-(4-hydroxy-phenyl)-1-pyrrolidin-1-yl-pro...)
Show SMILES NC(Cc1ccc(O)cc1)C(=O)N1CCCC1
Show InChI InChI=1/C13H18N2O2/c14-12(13(17)15-7-1-2-8-15)9-10-3-5-11(16)6-4-10/h3-6,12,16H,1-2,7-9,14H2
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n/an/a 1.50E+5n/an/an/an/an/an/a



University of Antwerp (UIA)

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase II.


Bioorg Med Chem Lett 12: 2825-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00603-0
BindingDB Entry DOI: 10.7270/Q279457M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50118937
PNG
(2-Amino-3-(4-hydroxy-phenyl)-1-pyrrolidin-1-yl-pro...)
Show SMILES NC(Cc1ccc(O)cc1)C(=O)N1CCCC1
Show InChI InChI=1/C13H18N2O2/c14-12(13(17)15-7-1-2-8-15)9-10-3-5-11(16)6-4-10/h3-6,12,16H,1-2,7-9,14H2
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Antwerp (UIA)

Curated by ChEMBL


Assay Description
Inhibitory activity against Dipeptidylpeptidase IV (DPP IV)


J Med Chem 46: 5005-14 (2003)


Article DOI: 10.1021/jm0308803
BindingDB Entry DOI: 10.7270/Q2W37X2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50243456
PNG
((S)-2-amino-3-(4-hydroxyphenyl)-1-(pyrrolidin-1-yl...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCCC1
Show InChI InChI=1/C13H18N2O2/c14-12(13(17)15-7-1-2-8-15)9-10-3-5-11(16)6-4-10/h3-6,12,16H,1-2,7-9,14H2/t12-/s2
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n/an/a 4.35E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP4 (unknown origin)


Bioorg Med Chem Lett 18: 4154-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.080
BindingDB Entry DOI: 10.7270/Q2G160N3
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50243456
PNG
((S)-2-amino-3-(4-hydroxyphenyl)-1-(pyrrolidin-1-yl...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCCC1
Show InChI InChI=1/C13H18N2O2/c14-12(13(17)15-7-1-2-8-15)9-10-3-5-11(16)6-4-10/h3-6,12,16H,1-2,7-9,14H2/t12-/s2
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n/an/a 7.69E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin)


Bioorg Med Chem Lett 18: 4154-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.080
BindingDB Entry DOI: 10.7270/Q2G160N3
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50118937
PNG
(2-Amino-3-(4-hydroxy-phenyl)-1-pyrrolidin-1-yl-pro...)
Show SMILES NC(Cc1ccc(O)cc1)C(=O)N1CCCC1
Show InChI InChI=1/C13H18N2O2/c14-12(13(17)15-7-1-2-8-15)9-10-3-5-11(16)6-4-10/h3-6,12,16H,1-2,7-9,14H2
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n/an/a 1.50E+5n/an/an/an/an/an/a



University of Antwerp (UIA)

Curated by ChEMBL


Assay Description
Inhibitory activity of compound against Dipeptidylpeptidase II (DPP II)


J Med Chem 46: 5005-14 (2003)


Article DOI: 10.1021/jm0308803
BindingDB Entry DOI: 10.7270/Q2W37X2F
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50273672
PNG
(CHEMBL459540 | N-[(2R)-2-Amino-3-phenylpropyl]-3-p...)
Show SMILES N[C@@H](CNC(=O)CCc1ccccc1)Cc1ccccc1
Show InChI InChI=1/C18H22N2O/c19-17(13-16-9-5-2-6-10-16)14-20-18(21)12-11-15-7-3-1-4-8-15/h1-10,17H,11-14,19H2,(H,20,21)/t17-/s2
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n/an/a 2.90E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney microsome aminopeptidase N by UV-visible spectrophotometer


Bioorg Med Chem 16: 9984-90 (2008)


Article DOI: 10.1016/j.bmc.2008.10.025
BindingDB Entry DOI: 10.7270/Q2JQ10VD
More data for this
Ligand-Target Pair