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25 similar compounds to monomer 116559

Compile data set for download or QSAR
Wt: 426.4
BDBM116919
Wt: 411.4
BDBM116922
Wt: 411.4
BDBM116924
Wt: 454.4
BDBM116930
Wt: 431.8
BDBM116934
Wt: 422.4
BDBM116943
Wt: 431.8
BDBM116944
Wt: 499.8
BDBM116954
Wt: 427.4
BDBM116771
Wt: 415.4
BDBM116962
Wt: 427.4
BDBM116842
Wt: 467.8
BDBM116987
Wt: 440.4
BDBM116390
Wt: 397.4
BDBM116395
Wt: 445.9
BDBM116398
Displayed 1 to 15 (of 25 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 116919,116922,116924,116930,116934,116943,116944,116954,116771,116962,116842,116987,116390,116395,116398   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116390
PNG
(US8637532, 71)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cccc(CNc2ncnc3c(cccc23)C(N)=O)c1
Show InChI InChI=1S/C25H24N6O2/c1-31(2)19-11-9-17(10-12-19)25(33)30-18-6-3-5-16(13-18)14-27-24-21-8-4-7-20(23(26)32)22(21)28-15-29-24/h3-13,15H,14H2,1-2H3,(H2,26,32)(H,30,33)(H,27,28,29)
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n/an/a 11.7n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM116395
PNG
(US8637532, 76)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccccc4)c3)ncnc12
Show InChI InChI=1S/C23H19N5O2/c24-21(29)18-10-5-11-19-20(18)26-14-27-22(19)25-13-15-6-4-9-17(12-15)28-23(30)16-7-2-1-3-8-16/h1-12,14H,13H2,(H2,24,29)(H,28,30)(H,25,26,27)
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n/an/a 1.90E+3n/an/an/an/a7.530



Merck Patent GmbH

US Patent


Assay Description
The kinase assay is performed as 384-well Flashplate assay (PerkinElmer LAS Germany GmbH). 3.4 nM His6-PDK1(Delta 1-50) (PDK1 that has a His-tag cons...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116398
PNG
(US8637532, 79)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)Cc4ccc(Cl)cc4)c3)ncnc12
Show InChI InChI=1S/C24H20ClN5O2/c25-17-9-7-15(8-10-17)12-21(31)30-18-4-1-3-16(11-18)13-27-24-20-6-2-5-19(23(26)32)22(20)28-14-29-24/h1-11,14H,12-13H2,(H2,26,32)(H,30,31)(H,27,28,29)
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n/an/a 91.7n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116771
PNG
(US8637532, 488)
Show SMILES CNc1ccc(cn1)C(=O)Nc1cccc(CNc2ncnc3c(cccc23)C(N)=O)c1
Show InChI InChI=1S/C23H21N7O2/c1-25-19-9-8-15(12-26-19)23(32)30-16-5-2-4-14(10-16)11-27-22-18-7-3-6-17(21(24)31)20(18)28-13-29-22/h2-10,12-13H,11H2,1H3,(H2,24,31)(H,25,26)(H,30,32)(H,27,28,29)
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n/an/a 66n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116390
PNG
(US8637532, 71)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cccc(CNc2ncnc3c(cccc23)C(N)=O)c1
Show InChI InChI=1S/C25H24N6O2/c1-31(2)19-11-9-17(10-12-19)25(33)30-18-6-3-5-16(13-18)14-27-24-21-8-4-7-20(23(26)32)22(21)28-15-29-24/h3-13,15H,14H2,1-2H3,(H2,26,32)(H,30,33)(H,27,28,29)
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n/an/a 0.110n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116398
PNG
(US8637532, 79)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)Cc4ccc(Cl)cc4)c3)ncnc12
Show InChI InChI=1S/C24H20ClN5O2/c25-17-9-7-15(8-10-17)12-21(31)30-18-4-1-3-16(11-18)13-27-24-20-6-2-5-19(23(26)32)22(20)28-14-29-24/h1-11,14H,12-13H2,(H2,26,32)(H,30,31)(H,27,28,29)
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n/an/a 8.40n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116771
PNG
(US8637532, 488)
Show SMILES CNc1ccc(cn1)C(=O)Nc1cccc(CNc2ncnc3c(cccc23)C(N)=O)c1
Show InChI InChI=1S/C23H21N7O2/c1-25-19-9-8-15(12-26-19)23(32)30-16-5-2-4-14(10-16)11-27-22-18-7-3-6-17(21(24)31)20(18)28-13-29-22/h2-10,12-13H,11H2,1H3,(H2,24,31)(H,25,26)(H,30,32)(H,27,28,29)
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n/an/a 0.690n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116842
PNG
(US8637532, 568)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(CO)cc4)c3)ncnc12
Show InChI InChI=1S/C24H21N5O3/c25-22(31)19-5-2-6-20-21(19)27-14-28-23(20)26-12-16-3-1-4-18(11-16)29-24(32)17-9-7-15(13-30)8-10-17/h1-11,14,30H,12-13H2,(H2,25,31)(H,29,32)(H,26,27,28)
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n/an/a 0.830n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116919
PNG
(US8637532, 646)
Show SMILES CNc1cccc(c1)C(=O)Nc1cccc(CNc2ncnc3c(cccc23)C(N)=O)c1
Show InChI InChI=1S/C24H22N6O2/c1-26-17-7-3-6-16(12-17)24(32)30-18-8-2-5-15(11-18)13-27-23-20-10-4-9-19(22(25)31)21(20)28-14-29-23/h2-12,14,26H,13H2,1H3,(H2,25,31)(H,30,32)(H,27,28,29)
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n/an/a 10n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116922
PNG
(US8637532, 649)
Show SMILES Cc1ccccc1C(=O)Nc1cccc(CNc2ncnc3c(cccc23)C(N)=O)c1
Show InChI InChI=1S/C24H21N5O2/c1-15-6-2-3-9-18(15)24(31)29-17-8-4-7-16(12-17)13-26-23-20-11-5-10-19(22(25)30)21(20)27-14-28-23/h2-12,14H,13H2,1H3,(H2,25,30)(H,29,31)(H,26,27,28)
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n/an/a 0.100n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116924
PNG
(US8637532, 651)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(CNc2ncnc3c(cccc23)C(N)=O)c1
Show InChI InChI=1S/C24H21N5O2/c1-15-5-2-7-17(11-15)24(31)29-18-8-3-6-16(12-18)13-26-23-20-10-4-9-19(22(25)30)21(20)27-14-28-23/h2-12,14H,13H2,1H3,(H2,25,30)(H,29,31)(H,26,27,28)
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n/an/a 0.170n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116930
PNG
(US8637532, 657)
Show SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1cccc(CNc2ncnc3c(cccc23)C(N)=O)c1
Show InChI InChI=1S/C25H22N6O3/c1-15(32)30-18-10-8-17(9-11-18)25(34)31-19-5-2-4-16(12-19)13-27-24-21-7-3-6-20(23(26)33)22(21)28-14-29-24/h2-12,14H,13H2,1H3,(H2,26,33)(H,30,32)(H,31,34)(H,27,28,29)
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n/an/a 0.650n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116934
PNG
(US8637532, 661)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cccc(Cl)c4)c3)ncnc12
Show InChI InChI=1S/C23H18ClN5O2/c24-16-6-2-5-15(11-16)23(31)29-17-7-1-4-14(10-17)12-26-22-19-9-3-8-18(21(25)30)20(19)27-13-28-22/h1-11,13H,12H2,(H2,25,30)(H,29,31)(H,26,27,28)
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n/an/a 0.170n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116943
PNG
(US8637532, 670)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(cc4)C#N)c3)ncnc12
Show InChI InChI=1S/C24H18N6O2/c25-12-15-7-9-17(10-8-15)24(32)30-18-4-1-3-16(11-18)13-27-23-20-6-2-5-19(22(26)31)21(20)28-14-29-23/h1-11,14H,13H2,(H2,26,31)(H,30,32)(H,27,28,29)
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n/an/a 0.630n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116944
PNG
(US8637532, 671)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(Cl)cc4)c3)ncnc12
Show InChI InChI=1S/C23H18ClN5O2/c24-16-9-7-15(8-10-16)23(31)29-17-4-1-3-14(11-17)12-26-22-19-6-2-5-18(21(25)30)20(19)27-13-28-22/h1-11,13H,12H2,(H2,25,30)(H,29,31)(H,26,27,28)
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n/an/a 0.0800n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116954
PNG
(US8637532, 681)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(Cl)c(c4)C(F)(F)F)c3)ncnc12
Show InChI InChI=1S/C24H17ClF3N5O2/c25-19-8-7-14(10-18(19)24(26,27)28)23(35)33-15-4-1-3-13(9-15)11-30-22-17-6-2-5-16(21(29)34)20(17)31-12-32-22/h1-10,12H,11H2,(H2,29,34)(H,33,35)(H,30,31,32)
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n/an/a 0.0800n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116962
PNG
(US8637532, 689)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccccc4F)c3)ncnc12
Show InChI InChI=1S/C23H18FN5O2/c24-19-10-2-1-7-16(19)23(31)29-15-6-3-5-14(11-15)12-26-22-18-9-4-8-17(21(25)30)20(18)27-13-28-22/h1-11,13H,12H2,(H2,25,30)(H,29,31)(H,26,27,28)
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n/an/a 1.60n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116987
PNG
(US8637532, 714)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4c(F)cc(Cl)cc4F)c3)ncnc12
Show InChI InChI=1S/C23H16ClF2N5O2/c24-13-8-17(25)19(18(26)9-13)23(33)31-14-4-1-3-12(7-14)10-28-22-16-6-2-5-15(21(27)32)20(16)29-11-30-22/h1-9,11H,10H2,(H2,27,32)(H,31,33)(H,28,29,30)
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n/an/a 0.0800n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM116390
PNG
(US8637532, 71)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cccc(CNc2ncnc3c(cccc23)C(N)=O)c1
Show InChI InChI=1S/C25H24N6O2/c1-31(2)19-11-9-17(10-12-19)25(33)30-18-6-3-5-16(13-18)14-27-24-21-8-4-7-20(23(26)32)22(21)28-15-29-24/h3-13,15H,14H2,1-2H3,(H2,26,32)(H,30,33)(H,27,28,29)
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n/an/a 0.520n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM116398
PNG
(US8637532, 79)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)Cc4ccc(Cl)cc4)c3)ncnc12
Show InChI InChI=1S/C24H20ClN5O2/c25-17-9-7-15(8-10-17)12-21(31)30-18-4-1-3-16(11-18)13-27-24-20-6-2-5-19(23(26)32)22(20)28-14-29-24/h1-11,14H,12-13H2,(H2,26,32)(H,30,31)(H,27,28,29)
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n/an/a 1.60n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM116771
PNG
(US8637532, 488)
Show SMILES CNc1ccc(cn1)C(=O)Nc1cccc(CNc2ncnc3c(cccc23)C(N)=O)c1
Show InChI InChI=1S/C23H21N7O2/c1-25-19-9-8-15(12-26-19)23(32)30-16-5-2-4-14(10-16)11-27-22-18-7-3-6-17(21(24)31)20(18)28-13-29-22/h2-10,12-13H,11H2,1H3,(H2,24,31)(H,25,26)(H,30,32)(H,27,28,29)
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Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM116842
PNG
(US8637532, 568)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(CO)cc4)c3)ncnc12
Show InChI InChI=1S/C24H21N5O3/c25-22(31)19-5-2-6-20-21(19)27-14-28-23(20)26-12-16-3-1-4-18(11-16)29-24(32)17-9-7-15(13-30)8-10-17/h1-11,14,30H,12-13H2,(H2,25,31)(H,29,32)(H,26,27,28)
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Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM116919
PNG
(US8637532, 646)
Show SMILES CNc1cccc(c1)C(=O)Nc1cccc(CNc2ncnc3c(cccc23)C(N)=O)c1
Show InChI InChI=1S/C24H22N6O2/c1-26-17-7-3-6-16(12-17)24(32)30-18-8-2-5-15(11-18)13-27-23-20-10-4-9-19(22(25)31)21(20)28-14-29-23/h2-12,14,26H,13H2,1H3,(H2,25,31)(H,30,32)(H,27,28,29)
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n/an/a 15n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM116922
PNG
(US8637532, 649)
Show SMILES Cc1ccccc1C(=O)Nc1cccc(CNc2ncnc3c(cccc23)C(N)=O)c1
Show InChI InChI=1S/C24H21N5O2/c1-15-6-2-3-9-18(15)24(31)29-17-8-4-7-16(12-17)13-26-23-20-11-5-10-19(22(25)30)21(20)27-14-28-23/h2-12,14H,13H2,1H3,(H2,25,30)(H,29,31)(H,26,27,28)
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Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM116924
PNG
(US8637532, 651)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(CNc2ncnc3c(cccc23)C(N)=O)c1
Show InChI InChI=1S/C24H21N5O2/c1-15-5-2-7-17(11-15)24(31)29-18-8-3-6-16(12-18)13-26-23-20-10-4-9-19(22(25)30)21(20)27-14-28-23/h2-12,14H,13H2,1H3,(H2,25,30)(H,29,31)(H,26,27,28)
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Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM116930
PNG
(US8637532, 657)
Show SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1cccc(CNc2ncnc3c(cccc23)C(N)=O)c1
Show InChI InChI=1S/C25H22N6O3/c1-15(32)30-18-10-8-17(9-11-18)25(34)31-19-5-2-4-16(12-19)13-27-24-21-7-3-6-20(23(26)33)22(21)28-14-29-24/h2-12,14H,13H2,1H3,(H2,26,33)(H,30,32)(H,31,34)(H,27,28,29)
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Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM116934
PNG
(US8637532, 661)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cccc(Cl)c4)c3)ncnc12
Show InChI InChI=1S/C23H18ClN5O2/c24-16-6-2-5-15(11-16)23(31)29-17-7-1-4-14(10-17)12-26-22-19-9-3-8-18(21(25)30)20(19)27-13-28-22/h1-11,13H,12H2,(H2,25,30)(H,29,31)(H,26,27,28)
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Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM116943
PNG
(US8637532, 670)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(cc4)C#N)c3)ncnc12
Show InChI InChI=1S/C24H18N6O2/c25-12-15-7-9-17(10-8-15)24(32)30-18-4-1-3-16(11-18)13-27-23-20-6-2-5-19(22(26)31)21(20)28-14-29-23/h1-11,14H,13H2,(H2,26,31)(H,30,32)(H,27,28,29)
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Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM116944
PNG
(US8637532, 671)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(Cl)cc4)c3)ncnc12
Show InChI InChI=1S/C23H18ClN5O2/c24-16-9-7-15(8-10-16)23(31)29-17-4-1-3-14(11-17)12-26-22-19-6-2-5-18(21(25)30)20(19)27-13-28-22/h1-11,13H,12H2,(H2,25,30)(H,29,31)(H,26,27,28)
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Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM116954
PNG
(US8637532, 681)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(Cl)c(c4)C(F)(F)F)c3)ncnc12
Show InChI InChI=1S/C24H17ClF3N5O2/c25-19-8-7-14(10-18(19)24(26,27)28)23(35)33-15-4-1-3-13(9-15)11-30-22-17-6-2-5-16(21(29)34)20(17)31-12-32-22/h1-10,12H,11H2,(H2,29,34)(H,33,35)(H,30,31,32)
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Merck Patent GmbH

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Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM116962
PNG
(US8637532, 689)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccccc4F)c3)ncnc12
Show InChI InChI=1S/C23H18FN5O2/c24-19-10-2-1-7-16(19)23(31)29-15-6-3-5-14(11-15)12-26-22-18-9-4-8-17(21(25)30)20(18)27-13-28-22/h1-11,13H,12H2,(H2,25,30)(H,29,31)(H,26,27,28)
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Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116395
PNG
(US8637532, 76)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccccc4)c3)ncnc12
Show InChI InChI=1S/C23H19N5O2/c24-21(29)18-10-5-11-19-20(18)26-14-27-22(19)25-13-15-6-4-9-17(12-15)28-23(30)16-7-2-1-3-8-16/h1-12,14H,13H2,(H2,24,29)(H,28,30)(H,25,26,27)
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n/an/a 54.6n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair