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10 similar compounds to monomer 121107

Compile data set for download or QSAR
Wt: 512.0
BDBM121047
Wt: 512.0
BDBM121048
Wt: 472.0
BDBM121055
Wt: 498.0
BDBM121106
Wt: 486.0
BDBM121211
Wt: 485.0
BDBM121248
Wt: 526.1
BDBM121257
Wt: 512.0
BDBM121259
Wt: 514.0
BDBM121279
Wt: 528.0
BDBM121280

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 121047,121048,121055,121106,121211,121248,121257,121259,121279,121280   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121106
PNG
(US8722896, (-)-(3R)-1-(Indolin-4-ylmethyl)- N-(9-c...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)[C@@H]1CCN(Cc2cccc3NCCc23)C1
Show InChI InChI=1/C28H36ClN3O3/c1-19(2)15-32(16-20-13-24(29)27-26(14-20)34-11-4-12-35-27)28(33)22-8-10-31(18-22)17-21-5-3-6-25-23(21)7-9-30-25/h3,5-6,13-14,19,22,30H,4,7-12,15-18H2,1-2H3/t22-/s2
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US Patent
0.206 -13.7n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121259
PNG
(US8722896, (-)-(3R)-1-(Indolin-7-ylmethyl)- N-(9-c...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCCN(Cc2cccc3CCNc23)C1
Show InChI InChI=1/C29H38ClN3O3/c1-20(2)16-33(17-21-14-25(30)28-26(15-21)35-12-5-13-36-28)29(34)24-8-4-11-32(19-24)18-23-7-3-6-22-9-10-31-27(22)23/h3,6-7,14-15,20,24,31H,4-5,8-13,16-19H2,1-2H3
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US Patent
2.62 -12.2n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121047
PNG
(US8722896, (-)-(3R)-1-(1-Methyl-indol-4- ylmethyl)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc3N(C)CCc23)C1
Show InChI InChI=1/C29H38ClN3O3/c1-20(2)16-33(17-21-14-25(30)28-27(15-21)35-12-5-13-36-28)29(34)23-8-11-32(19-23)18-22-6-4-7-26-24(22)9-10-31(26)3/h4,6-7,14-15,20,23H,5,8-13,16-19H2,1-3H3
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US Patent
2.92 -12.1n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121259
PNG
(US8722896, (-)-(3R)-1-(Indolin-7-ylmethyl)- N-(9-c...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCCN(Cc2cccc3CCNc23)C1
Show InChI InChI=1/C29H38ClN3O3/c1-20(2)16-33(17-21-14-25(30)28-26(15-21)35-12-5-13-36-28)29(34)24-8-4-11-32(19-24)18-23-7-3-6-22-9-10-31-27(22)23/h3,6-7,14-15,20,24,31H,4-5,8-13,16-19H2,1-2H3
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US Patent
3.29 -12.0n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121106
PNG
(US8722896, (-)-(3R)-1-(Indolin-4-ylmethyl)- N-(9-c...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)[C@@H]1CCN(Cc2cccc3NCCc23)C1
Show InChI InChI=1/C28H36ClN3O3/c1-19(2)15-32(16-20-13-24(29)27-26(14-20)34-11-4-12-35-27)28(33)22-8-10-31(18-22)17-21-5-3-6-25-23(21)7-9-30-25/h3,5-6,13-14,19,22,30H,4,7-12,15-18H2,1-2H3/t22-/s2
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US Patent
4.70 -11.8n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121279
PNG
(US8722896, (+/-)-4-(Indolin-7-ylmethyl)-N-(9- chlo...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CN(Cc2cccc3CCNc23)CCO1
Show InChI InChI=1/C28H36ClN3O4/c1-19(2)15-32(16-20-13-23(29)27-24(14-20)34-10-4-11-36-27)28(33)25-18-31(9-12-35-25)17-22-6-3-5-21-7-8-30-26(21)22/h3,5-6,13-14,19,25,30H,4,7-12,15-18H2,1-2H3
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US Patent
4.77 -11.8n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121047
PNG
(US8722896, (-)-(3R)-1-(1-Methyl-indol-4- ylmethyl)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc3N(C)CCc23)C1
Show InChI InChI=1/C29H38ClN3O3/c1-20(2)16-33(17-21-14-25(30)28-27(15-21)35-12-5-13-36-28)29(34)23-8-11-32(19-23)18-22-6-4-7-26-24(22)9-10-31(26)3/h4,6-7,14-15,20,23H,5,8-13,16-19H2,1-3H3
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US Patent
8.82 -11.4n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121280
PNG
(US8722896, (+/-)-4-(N-methyl-indolin-7- ylmethyl)-...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CN(Cc2cccc3CCN(C)c23)CCO1
Show InChI InChI=1/C29H38ClN3O4/c1-20(2)16-33(17-21-14-24(30)28-25(15-21)35-11-5-12-37-28)29(34)26-19-32(10-13-36-26)18-23-7-4-6-22-8-9-31(3)27(22)23/h4,6-7,14-15,20,26H,5,8-13,16-19H2,1-3H3
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US Patent
14.2 -11.1n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121048
PNG
(US8722896, (-)-(3R)-1-(1-Methyl-indol-7- ylmethyl)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc3CCN(C)c23)C1
Show InChI InChI=1/C29H38ClN3O3/c1-20(2)16-33(17-21-14-25(30)28-26(15-21)35-12-5-13-36-28)29(34)24-9-11-32(19-24)18-23-7-4-6-22-8-10-31(3)27(22)23/h4,6-7,14-15,20,24H,5,8-13,16-19H2,1-3H3
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US Patent
20 -10.9n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121279
PNG
(US8722896, (+/-)-4-(Indolin-7-ylmethyl)-N-(9- chlo...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CN(Cc2cccc3CCNc23)CCO1
Show InChI InChI=1/C28H36ClN3O4/c1-19(2)15-32(16-20-13-23(29)27-24(14-20)34-10-4-11-36-27)28(33)25-18-31(9-12-35-25)17-22-6-3-5-21-7-8-30-26(21)22/h3,5-6,13-14,19,25,30H,4,7-12,15-18H2,1-2H3
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20.4 -10.9n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121211
PNG
(US8722896, (+/-)-2-Methyl-3-(indolin-7- ylmethylam...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2CCNc12
Show InChI InChI=1/C27H36ClN3O3/c1-18(2)16-31(17-20-12-23(28)26-24(13-20)33-10-5-11-34-26)27(32)19(3)14-29-15-22-7-4-6-21-8-9-30-25(21)22/h4,6-7,12-13,18-19,29-30H,5,8-11,14-17H2,1-3H3
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21.2 -10.9n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121280
PNG
(US8722896, (+/-)-4-(N-methyl-indolin-7- ylmethyl)-...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CN(Cc2cccc3CCN(C)c23)CCO1
Show InChI InChI=1/C29H38ClN3O4/c1-20(2)16-33(17-21-14-24(30)28-25(15-21)35-11-5-12-37-28)29(34)26-19-32(10-13-36-26)18-23-7-4-6-22-8-9-31(3)27(22)23/h4,6-7,14-15,20,26H,5,8-13,16-19H2,1-3H3
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US Patent
24.8 -10.8n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121211
PNG
(US8722896, (+/-)-2-Methyl-3-(indolin-7- ylmethylam...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2CCNc12
Show InChI InChI=1/C27H36ClN3O3/c1-18(2)16-31(17-20-12-23(28)26-24(13-20)33-10-5-11-34-26)27(32)19(3)14-29-15-22-7-4-6-21-8-9-30-25(21)22/h4,6-7,12-13,18-19,29-30H,5,8-11,14-17H2,1-3H3
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US Patent
26.1 -10.8n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121248
PNG
(US8722896, (-)-(3R)-1-(3-Ethylbenzyl)-N-(9- chloro...)
Show SMILES CCc1cccc(CN2CCC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c1
Show InChI InChI=1/C28H37ClN2O3/c1-4-21-7-5-8-22(13-21)17-30-10-9-24(19-30)28(32)31(16-20(2)3)18-23-14-25(29)27-26(15-23)33-11-6-12-34-27/h5,7-8,13-15,20,24H,4,6,9-12,16-19H2,1-3H3
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US Patent
30.2 -10.7n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121055
PNG
(US8722896, (-)-(3R)-1-(2-Aminobenzyl)-N- (9-chloro...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2ccccc2N)C1
Show InChI InChI=1/C26H34ClN3O3/c1-18(2)14-30(15-19-12-22(27)25-24(13-19)32-10-5-11-33-25)26(31)21-8-9-29(17-21)16-20-6-3-4-7-23(20)28/h3-4,6-7,12-13,18,21H,5,8-11,14-17,28H2,1-2H3
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31.5 -10.6n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121055
PNG
(US8722896, (-)-(3R)-1-(2-Aminobenzyl)-N- (9-chloro...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2ccccc2N)C1
Show InChI InChI=1/C26H34ClN3O3/c1-18(2)14-30(15-19-12-22(27)25-24(13-19)32-10-5-11-33-25)26(31)21-8-9-29(17-21)16-20-6-3-4-7-23(20)28/h3-4,6-7,12-13,18,21H,5,8-11,14-17,28H2,1-2H3
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38.7 -10.5n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121048
PNG
(US8722896, (-)-(3R)-1-(1-Methyl-indol-7- ylmethyl)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc3CCN(C)c23)C1
Show InChI InChI=1/C29H38ClN3O3/c1-20(2)16-33(17-21-14-25(30)28-26(15-21)35-12-5-13-36-28)29(34)24-9-11-32(19-24)18-23-7-4-6-22-8-10-31(3)27(22)23/h4,6-7,14-15,20,24H,5,8-13,16-19H2,1-3H3
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54 -10.3n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121257
PNG
(US8722896, (-)-(3R)-1-(N-methyl-indolin-7- ylmethy...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCCN(Cc2cccc3CCN(C)c23)C1
Show InChI InChI=1/C30H40ClN3O3/c1-21(2)17-34(18-22-15-26(31)29-27(16-22)36-13-6-14-37-29)30(35)25-9-5-11-33(20-25)19-24-8-4-7-23-10-12-32(3)28(23)24/h4,7-8,15-16,21,25H,5-6,9-14,17-20H2,1-3H3
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87.3 -10.0n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121248
PNG
(US8722896, (-)-(3R)-1-(3-Ethylbenzyl)-N-(9- chloro...)
Show SMILES CCc1cccc(CN2CCC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c1
Show InChI InChI=1/C28H37ClN2O3/c1-4-21-7-5-8-22(13-21)17-30-10-9-24(19-30)28(32)31(16-20(2)3)18-23-14-25(29)27-26(15-23)33-11-6-12-34-27/h5,7-8,13-15,20,24H,4,6,9-12,16-19H2,1-3H3
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UniChem

Similars

US Patent
88.8 -10.0n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
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