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16 similar compounds to monomer 129181

Compile data set for download or QSAR
Wt: 433.9
BDBM129022
Wt: 407.8
BDBM129023
Wt: 433.9
BDBM129024
Wt: 413.8
BDBM129011
Wt: 419.9
BDBM129035
Wt: 391.8
BDBM129026
Wt: 431.9
BDBM129054
Wt: 363.7
BDBM129048
Wt: 405.8
BDBM129045
Wt: 417.8
BDBM129047
Wt: 431.9
BDBM129058
Wt: 417.8
BDBM129046
Wt: 421.8
BDBM129059
Wt: 403.8
BDBM129124
Wt: 435.9
BDBM129135

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 129022,129023,129024,129011,129035,129026,129054,129048,129045,129047,129058,129046,129059,129124,129135   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129047
PNG
(US8802674, 81)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(NC2CCC2)n1)C(=O)N1CCOCC1
Show InChI InChI=1S/C20H24ClN5O3/c1-28-17-11-13(19(27)26-7-9-29-10-8-26)5-6-16(17)24-20-22-12-15(21)18(25-20)23-14-3-2-4-14/h5-6,11-12,14H,2-4,7-10H2,1H3,(H2,22,23,24,25)
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1.5n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129058
PNG
(US8802674, 104)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(NCCC2CC2)n1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H26ClN5O3/c1-29-18-12-15(20(28)27-8-10-30-11-9-27)4-5-17(18)25-21-24-13-16(22)19(26-21)23-7-6-14-2-3-14/h4-5,12-14H,2-3,6-11H2,1H3,(H2,23,24,25,26)
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1.80n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129124
PNG
(US8802674, 217)
Show SMILES CNc1nc(Nc2ccc(cc2OC2CC2)C(=O)N2CCOCC2)ncc1Cl
Show InChI InChI=1S/C19H22ClN5O3/c1-21-17-14(20)11-22-19(24-17)23-15-5-2-12(10-16(15)28-13-3-4-13)18(26)25-6-8-27-9-7-25/h2,5,10-11,13H,3-4,6-9H2,1H3,(H2,21,22,23,24)
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2n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129054
PNG
(US8802674, 91)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(NC2(C)CCC2)n1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H26ClN5O3/c1-21(6-3-7-21)26-18-15(22)13-23-20(25-18)24-16-5-4-14(12-17(16)29-2)19(28)27-8-10-30-11-9-27/h4-5,12-13H,3,6-11H2,1-2H3,(H2,23,24,25,26)
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2.40n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129046
PNG
(US8802674, 80)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(NCC2CC2)n1)C(=O)N1CCOCC1
Show InChI InChI=1S/C20H24ClN5O3/c1-28-17-10-14(19(27)26-6-8-29-9-7-26)4-5-16(17)24-20-23-12-15(21)18(25-20)22-11-13-2-3-13/h4-5,10,12-13H,2-3,6-9,11H2,1H3,(H2,22,23,24,25)
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2.70n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129035
PNG
(US8802674, 67)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(NCC(C)C)n1)C(=O)N1CCOCC1
Show InChI InChI=1S/C20H26ClN5O3/c1-13(2)11-22-18-15(21)12-23-20(25-18)24-16-5-4-14(10-17(16)28-3)19(27)26-6-8-29-9-7-26/h4-5,10,12-13H,6-9,11H2,1-3H3,(H2,22,23,24,25)
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4n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129024
PNG
(US8802674, 41)
Show SMILES CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOC(CC(C)C)C2)ncc1Cl
Show InChI InChI=1S/C21H28ClN5O3/c1-13(2)9-15-12-27(7-8-30-15)20(28)14-5-6-17(18(10-14)29-4)25-21-24-11-16(22)19(23-3)26-21/h5-6,10-11,13,15H,7-9,12H2,1-4H3,(H2,23,24,25,26)
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4.20n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129026
PNG
(US8802674, 49)
Show SMILES CCOc1cc(ccc1Nc1ncc(Cl)c(NC)n1)C(=O)N1CCOCC1
Show InChI InChI=1S/C18H22ClN5O3/c1-3-27-15-10-12(17(25)24-6-8-26-9-7-24)4-5-14(15)22-18-21-11-13(19)16(20-2)23-18/h4-5,10-11H,3,6-9H2,1-2H3,(H2,20,21,22,23)
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4.30n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129023
PNG
(US8802674, 40)
Show SMILES CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2CO)ncc1Cl
Show InChI InChI=1S/C18H22ClN5O4/c1-20-16-13(19)8-21-18(23-16)22-14-4-3-11(7-15(14)27-2)17(26)24-5-6-28-10-12(24)9-25/h3-4,7-8,12,25H,5-6,9-10H2,1-2H3,(H2,20,21,22,23)
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4.40n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129022
PNG
(US8802674, 39)
Show SMILES CCC1(CC)CN(CCO1)C(=O)c1ccc(Nc2ncc(Cl)c(NC)n2)c(OC)c1
Show InChI InChI=1S/C21H28ClN5O3/c1-5-21(6-2)13-27(9-10-30-21)19(28)14-7-8-16(17(11-14)29-4)25-20-24-12-15(22)18(23-3)26-20/h7-8,11-12H,5-6,9-10,13H2,1-4H3,(H2,23,24,25,26)
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5.5n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129059
PNG
(US8802674, 105)
Show SMILES COCCNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1Cl
Show InChI InChI=1S/C19H24ClN5O4/c1-27-8-5-21-17-14(20)12-22-19(24-17)23-15-4-3-13(11-16(15)28-2)18(26)25-6-9-29-10-7-25/h3-4,11-12H,5-10H2,1-2H3,(H2,21,22,23,24)
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9.40n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129135
PNG
(US8802674, 230)
Show SMILES COC(C)CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1Cl
Show InChI InChI=1S/C20H26ClN5O4/c1-13(28-2)11-22-18-15(21)12-23-20(25-18)24-16-5-4-14(10-17(16)29-3)19(27)26-6-8-30-9-7-26/h4-5,10,12-13H,6-9,11H2,1-3H3,(H2,22,23,24,25)
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9.60n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129045
PNG
(US8802674, 79)
Show SMILES CNc1nc(Nc2ccc(cc2OC(C)C)C(=O)N2CCOCC2)ncc1Cl
Show InChI InChI=1S/C19H24ClN5O3/c1-12(2)28-16-10-13(18(26)25-6-8-27-9-7-25)4-5-15(16)23-19-22-11-14(20)17(21-3)24-19/h4-5,10-12H,6-9H2,1-3H3,(H2,21,22,23,24)
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15.6n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129048
PNG
(US8802674, 82)
Show SMILES CNc1nc(Nc2ccc(cc2O)C(=O)N2CCOCC2)ncc1Cl
Show InChI InChI=1S/C16H18ClN5O3/c1-18-14-11(17)9-19-16(21-14)20-12-3-2-10(8-13(12)23)15(24)22-4-6-25-7-5-22/h2-3,8-9,23H,4-7H2,1H3,(H2,18,19,20,21)
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28.9n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM129011
PNG
(US8802674, 7)
Show SMILES CNc1nc(Nc2ccc(cc2OC(F)F)C(=O)N2CCOCC2)ncc1Cl
Show InChI InChI=1S/C17H18ClF2N5O3/c1-21-14-11(18)9-22-17(24-14)23-12-3-2-10(8-13(12)28-16(19)20)15(26)25-4-6-27-7-5-25/h2-3,8-9,16H,4-7H2,1H3,(H2,21,22,23,24)
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4.90E+4n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8802674 (2014)


BindingDB Entry DOI: 10.7270/Q2GF0S6N
More data for this
Ligand-Target Pair